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Brian J. Anderson, MD, MSCE

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Associate Medical Director, Medical Intensive Care Unit, Hospital of the University of Pennsylvania
Department: Medicine

Contact information
3400 Spruce Street
5036 Gates Building
Philadelphia, PA 19104
Office: 215-662-7915
Fax: 215-662-2856
BS (Molecular and Cellular Biology)
Johns Hopkins University, 2005.
MD (Medicine)
George Washington University, 2009.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 2015.
Post-Graduate Training
Resident in Internal Medicine, NewYork-Presbyterian / Weill Cornell Medical Center, 2009-2012.
Fellow in Pulmonary and Critical Care Medicine, University of Pennsylvania, 2012-2015.
NRSA Postdoctoral Research Fellow, University of Pennsylvania, 2016-2016.
Internal Medicine - American Board of Internal Medicine, 2012.
Pulmonary Diseases - American Board of Internal Medicine, 2014.
Critical Care Medicine - American Board of Internal Medicine, 2016.
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Description of Clinical Expertise

Dr. Anderson is board certified in Internal Medicine, Pulmonary Disease and Critical Care Medicine, and serves as the Associate Medical Director of Medical Intensive Care at the Hospital of the University of Pennsylvania. He currently attends on several critical care services at the Hospital of the University of Pennsylvania including the Medical Intensive Care Unit, the Critical Care Outreach and Procedure Service, and the Nocturnal Intensive Care Outreach Service. His clinical expertise include sepsis and septic shock, mechanical ventilation, acute respiratory failure and the acute respiratory distress syndrome, delirium, and post-intensive care syndrome.

Description of Research Expertise

Dr. Anderson's research focuses on identifying clinical and molecular risk factors for neurocognitive impairment and other organ dysfunctions in critical illness. Dr. Anderson oversees Penn's cohort study of delirium and cognitive impairment in sepsis survivors. Current studies focus on 1) the role of systemic markers of cerebral injury to identify survivors at high risk of neurocognitive impairment, and 2) neuronal excitotoxicity as a mechanism of neuronal death and neurocognitive impairment in sepsis survivors.

Dr. Anderson also collaborates with Dr. Nuala Meyer, Dr. John Reilly and Dr. Michael Shashaty on epidemiologic and molecular studies of acute respiratory distress syndrome and acute kidney injury in critically ill patients.

Selected Publications

Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott, J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, Matthay MA, Meyer NJ, Christie JD: Plasma sTNFR1 and IL8 for Prognostic Enrichment in Sepsis Trials: A Prospective Cohort Study. Critical Care 23(40), Dec 2019.

Anderson BJ, Do D, Chivers C, Choi K, Gitelman Y, Mehta SJ, Panchanadam V, Gudowski S, Pierce M, Cereda M, Christie JD, Schweickert WD, Gabrielli A, Huffenberger H, Draugelis M, Fuchs BD: Clinical Impact of an Electronic Dashboard and Alert System for Sedation Minimization and Ventilator Liberation: A Before-After Study. Critical Care Explorations 1(10), Oct 2019.

Hippensteel JA, Anderson BJ, Orfila J, McMurtry S, Dietz RM, Su G, Ford J, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt R, Meyer NJ, Herson PS, Schmidt EP : Circulating heparan sulfate fragments mediate septic cognitive dysfunction. Journal of Clinical Investigation 129(4): 1779-1784, Apr 2019.

McDonald MD, Sandsmark DK, Palakshappa JA, Mikkelsen ME, Anderson BJ, Gutsche JT: Long-term Outcomes After Extracorporeal Life Support for Acute Respiratory Failure. Journal of Cardiothoracic and Vascular Anesthesia 33(1): 72-79, Jan 2019.

Jones TK, Feng R, Kerchberger VE, Reilly JP, Anderson BJ, Shashaty MGS, Wang F, Dunn TG, Riley TR, Abbott J, Ittner CAG, Christiani DC, Mikacenic C, Wurfel MM, Ware LB, Calfee CS, Matthay MA, Christie JD, Meyer NJ: Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS. American Journal of Respiratory and Critical Care Medicine 201(1): 47-56, Jan 2020.

Faust HE, Reilly JP, Anderson BJ, Ittner CAD, Forker CM, Zhang P, Weaver BA, Holena DN, Lanken PN, Christie JD, Meyer NJ, Mangalmurti NS, Shashaty MGS: Plasma Mitochondrial DNA Levels are Associated with Acute Respiratory Distress Syndrome in Trauma and Sepsis Patients. Chest 157(1): 67-76, Jan 2020.

Anderson BJ, Chesley CF, Theodore M, Christie C, Tino R, Wysoczanski A, Ramphal K, Oyster M, Kalman L, Porteous MK, Bermudez CA, Cantu E, Kolson DL, Christie JD, Diamond JD: Incidence, Risk Factors, and Clinical Implications of Post-operative Delirium in Lung Transplant Recipients. Journal of Heart and Lung Transplantation 37(6): 755-762, Jun 2018.

Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ: Plasma Angiopoietin-2 as a Potential Causal Marker in ARDS Development: Evidence from Mendelian Randomization and Mediation Analysis. Intensive Care Medicine 44(11): 1849-1858, Nov 2018.

Anderson BJ, Reilly JP, Shashaty MGS, Palakshappa JA, Wysoczanski A, Dunn TG, Kazi A, Tommasini A, Mikkelsen ME, Schweickert WD, Kolson DL, Christie JD, Meyer NJ: Admission plasma levels of the neuronal injury marker neuron specific enolase are associated with mortality and delirium in sepsis Journal of Critical Care 36: 18-23, Dec 2016.

Cohen DG, Christie JD, Anderson BJ, Diamond JM, Judy RP, Shah RJ, Cantu E, Bellamy SL, Blumenthal NP, Demissie E, Hopkins RO, Mikkelsen ME: Cognitive function, mental health, and health-related quality of life after lung transplantation. Annals of the American Thoracic Society 11(4): 522-30, May 2014.

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Last updated: 10/07/2020
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