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Brian J. Anderson, MD, MSCE

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Associate Medical Director, Medical Intensive Care Unit, Hospital of the University of Pennsylvania
Department: Medicine

Contact information
3400 Spruce Street
5036 Gates Building
Philadelphia, PA 19104
Office: 215-662-7915
Fax: 215-662-2856
BS (Molecular and Cellular Biology)
Johns Hopkins University, 2005.
MD (Medicine)
George Washington University, 2009.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 2015.
Post-Graduate Training
Resident in Internal Medicine, NewYork-Presbyterian / Weill Cornell Medical Center, 2009-2012.
Fellow in Pulmonary and Critical Care Medicine, University of Pennsylvania, 2012-2015.
NRSA Postdoctoral Research Fellow, University of Pennsylvania, 2016-2016.
Internal Medicine - American Board of Internal Medicine, 2012.
Pulmonary Diseases - American Board of Internal Medicine, 2014.
Critical Care Medicine - American Board of Internal Medicine, 2016.
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Description of Clinical Expertise

Dr. Anderson is board certified in Internal Medicine, Pulmonary Disease and Critical Care Medicine, and serves as the Associate Medical Director of Medical Intensive Care at the Hospital of the University of Pennsylvania. He currently attends on several critical care services at the Hospital of the University of Pennsylvania including the Medical Intensive Care Unit, the Critical Care Outreach and Procedure Service, and the Nocturnal Intensive Care Outreach Service. His clinical expertise include sepsis and septic shock, mechanical ventilation, acute respiratory failure and the acute respiratory distress syndrome, delirium, and post-intensive care syndrome.

Description of Research Expertise

Dr. Anderson's research focuses on identifying clinical and molecular risk factors for neurocognitive impairment and other organ dysfunctions in critical illness. Dr. Anderson oversees Penn's cohort study of delirium and cognitive impairment in sepsis survivors. Current studies focus on 1) the role of systemic markers of cerebral injury to identify survivors at high risk of neurocognitive impairment, and 2) neuronal excitotoxicity as a mechanism of neuronal death and neurocognitive impairment in sepsis survivors.

Dr. Anderson also collaborates with Dr. Nuala Meyer, Dr. John Reilly and Dr. Michael Shashaty on epidemiologic and molecular studies of acute respiratory distress syndrome and acute kidney injury in critically ill patients.

Selected Publications

Hippensteel JA, Anderson BJ, Orfila J, McMurtry S, Dietz RM, Su G, Ford J, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt R, Meyer NJ, Herson PS, Schmidt EP : Circulating heparan sulfate fragments mediate septic cognitive dysfunction. Journal of Clinical Investigation 129(4): 1779-1784, April 2019.

McDonald MD, Sandsmark DK, Palakshappa JA, Mikkelsen ME, Anderson BJ, Gutsche JT: Long-term Outcomes After Extracorporeal Life Support for Acute Respiratory Failure. Journal of Cardiothoracic and Vascular Anesthesia 33(1): 72-79, January 2019.

Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ: Plasma Angiopoietin-2 as a Potential Causal Marker in ARDS Development: Evidence from Mendelian Randomization and Mediation Analysis. Intensive Care Medicine 44(11): 1849-1858, Nov 2018.

Palakshappa JA, Reilly JP, Schweickert WD, Anderson BJ, Khoury V, Shashaty MG, Fitzgerald D, Forker C, Butler K, Ittner CA, Files DC, Bonk MP, Christie JD, Meyer NJ: Quantitative Peripheral Muscle Ultrasound in Sepsis: Muscle Area Superior to Thickness. Journal of Critical Care 47: 324-30, Oct 2018.

Anderson BJ, Chesley CF, Theodore M, Christie C, Tino R, Wysoczanski A, Ramphal K, Oyster M, Kalman L, Porteous MK, Bermudez CA, Cantu E, Kolson DL, Christie JD, Diamond JD: Incidence, Risk Factors, and Clinical Implications of Post-operative Delirium in Lung Transplant Recipients. Journal of Heart and Lung Transplantation 37(6): 755-762, Jun 2018.

Meyer NJ, Reilly JP, Anderson BJ, Palakshappa JA, Jones TK, Dunn TG, Shashaty MGS, Feng R, Christie JD, Palardy JE, Opal SM: Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist (rhIL1RA) for Sepsis Varies by Initial IL1RA Plasma Concentration. Critical Care Medicine 46(1): 21-28, Jan 2018.

Anderson BJ, Reilly JP, Shashaty MGS, Palakshappa JA, Wysoczanski A, Dunn TG, Kazi A, Tommasini A, Mikkelsen ME, Schweickert WD, Kolson DL, Christie JD, Meyer NJ: Admission plasma levels of the neuronal injury marker neuron specific enolase are associated with mortality and delirium in sepsis Journal of Critical Care 36: 18-23, Dec 2016.

Reilly JP, Anderson BJ, Hudock KM, Dunn TG, Kazi A, Tommasini A, Charles D, Shashaty MGS, Mikkelsen ME, Christie JD, Meyer NJ: Neutropenic sepsis is associated with distinct clinical and biological characteristics: A cohort study of severe sepsis. Critical Care 18(20), Jul 2016.

Reilly JP, Anderson BJ, Mangalmurti NS, Nguyen TD, Holena DN, Wu Q, Nguyen E, Reilly MP, Lanken PN, Christie JD, Meyer NJ, Shashaty MGS: The ABO Histo-Blood Group and Acute Kidney Injury Risk in Critically Ill Trauma and Sepsis Patients. Clinical Journal of the American Society of Nephrology 10(11): 1911-20, Nov 2015.

Cohen DG, Christie JD, Anderson BJ, Diamond JM, Judy RP, Shah RJ, Cantu E, Bellamy SL, Blumenthal NP, Demissie E, Hopkins RO, Mikkelsen ME: Cognitive function, mental health, and health-related quality of life after lung transplantation. Annals of the American Thoracic Society 11(4): 522-30, May 2014.

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Last updated: 10/16/2019
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