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Jillian Frances Evans, PhD

Adjunct Professor of Medicine (Pulmonary, Allergy and Critical Care)
Department: Medicine

Contact information
3450 Hamilton Walk
216 Stemmler Hall
Philadelphia, PA 19104
Office: 215-573-9918
Fax: 215-746-0376
Lab: 215-746-3599
BSc (Biochemistry)
Auckland University, New Zealand, 1972.
MSc (Cell Biology)
Auckland University, New Zealand, 1974.
PhD (Biochemistry)
University of British Columbia, Canada, 1978.
Post-Graduate Training
Project Management Techniques, Australian Institute of Management, 1988-1988.
Advanced DNA Course, Life Technologies, BRL, 1993-1993.
Polymerase Chain Reaction Course, Exon-Intron, 1994-1994.
cDNA Library Techniques, Life Technologies, BRL, 1995-1995.
Genetics Course, Bar Harbor, Maine, 1999-1999.
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Description of Research Expertise

World class scientist and drug developer in fields of inflammation and respiratory diseases; international authority on leukotriene and eicosanoid biochemistry; experienced integrator of chemistry, biology and metabolism drug development teams; outstanding motivational, interpersonal and communication skills

Selected Publications

Jilly F. Evans, Ryan W. Rue, Alexander R. Mukhitov, Kseniya Obraztsova, Carly J. Smith, Vera P. Krymskaya : Inhibition of Growth of TSC2-Null Cells by a PI3K/mTOR Inhibitor but Not by a Selective MNK1/2 Inhibitor Biomolecules 10(1): 28, Jan 2020.

Obraztsova K, Evans JF and Krymskaya VP.: Syndecan-2: Old player in a new field. Am J Respir Cell Mol Biol 60(1): 611-612, Jan 2019.

Blanca E. Himes, Kseniya Obraztsova, Lurong Lian, Maya Shumyatcher, Ryan Rue, Elena N. Atochina-Vasserman, Stella K. Hur, Marisa S. Bartolomei, Jilly F. Evans, Vera P. Krymskaya: Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells PLoS One. 13(5): e0197105, May 2018.

Bain Gretchen, Shannon Kristen E, Huang Fei, Darlington Janice, Goulet Lance, Prodanovich Patricia, Ma Gina L, Santini Angelina M, Stein Adam J, Lonergan Dave, King Christopher D, Calderon Imelda, Lai Andiliy, Hutchinson John H, Evans Jilly F: Selective inhibition of autotaxin is efficacious in mouse models of liver fibrosis. The Journal of pharmacology and experimental therapeutics 360(1): 1-13, Jan 2017.

Sun Ying, Zhang Weici, Evans Jilly F, Floreani Annarosa, Zou Zhengsheng, Nishio Yukiko, Qi Ruizhao, Leung Patrick S C, Bowlus Christopher L, Gershwin M Eric: Autotaxin, pruritus and primary biliary cholangitis (PBC). Autoimmunity reviews 15(8): 795-800, Aug 2016.

Stein Adam J, Bain Gretchen, Prodanovich Pat, Santini Angelina M, Darlington Janice, Stelzer Nina M P, Sidhu Ranjinder S, Schaub Jeffrey, Goulet Lance, Lonergan Dave, Calderon Imelda, Evans Jilly F, Hutchinson John H: Structural basis for inhibition of human autotaxin by four potent compounds with distinct modes of binding. Molecular pharmacology 88(6): 982-92, Dec 2015.

Schafer P H, Parton A, Capone L, Cedzik D, Brady H, Evans J F, Man H-W, Muller G W, Stirling D I, Chopra R: Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity. Cellular signalling 26(9): 2016-29, Sep 2014.

Bäck Magnus, Powell William S, Dahlén Sven-Erik, Drazen Jeffrey M, Evans Jilly F, Serhan Charles N, Shimizu Takao, Yokomizo Takehiko, Rovati G Enrico: Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7. British journal of pharmacology 171(15): 3551-74, Aug 2014.

Bain Gretchen, King Christopher D, Schaab Kevin, Rewolinski Melissa, Norris Virginia, Ambery Claire, Bentley Jane, Yamada Masanori, Santini Angelina M, van de Wetering de Rooij Jeroen, Stock Nicholas, Zunic Jasmine, Hutchinson John H, Evans Jilly F: Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor. British journal of clinical pharmacology 75(3): 779-90, Mar 2013.

Lopez-Girona A, Mendy D, Ito T, Miller K, Gandhi A K, Kang J, Karasawa S, Carmel G, Jackson P, Abbasian M, Mahmoudi A, Cathers B, Rychak E, Gaidarova S, Chen R, Schafer P H, Handa H, Daniel T O, Evans J F, Chopra R: Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia 26(11): 2326-35, Nov 2012.

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Last updated: 08/24/2020
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