World class scientist and drug developer in fields of inflammation and respiratory diseases; international authority on leukotriene and eicosanoid biochemistry; experienced integrator of chemistry, biology and metabolism drug development teams; outstanding motivational, interpersonal and communication skills
Selected Publications
Alexander R Mukhitov, Jilly F. Evans, Tiegang Han, Owen A. Ledwell, Ryan Rue, Kseniya Obraztsova, Susan M. Lin, Maria C. Basil, Edward Cantu, Yan Tang, Elizabeth P Henske, and Vera P Krymskaya: Extracellular Matrix and Fibroblast Activation in Lymphangioleiomyomatosis. American Journal of Respiratory Cell and Molecular Biology Page: epub ahead of press, Sep 2025.
Evans, J.F., Ledwell, O.A., Tang, Y., Rue, R., Mukhitov, A.R., Lin, S.M., Kanth, S.V., Henske E.P., Krymskaya, V.P.: The bi-steric mTORCI-selective inhibitor RMC-5552 reduces mTORCI signaling and growth in lymphangioleiomyomatosis-associated lung fibroblasts. American Journal of Respiratory Cell and Molecular Biology 72(6): 643-656, Jun 2025.
Stella Bähr *, Ryan W. Rue, Carly J. Smith, Jillian F. Evans, Hubert Köster, Vera P. Krymskaya, Dirk Pleimes: Repurposing Nitazoxanide for Potential Treatment of Rare Disease Lymphangioleiomyomatosis. Biomolecules 14(1): 1236-1238, Sep 2024.
Lin SM, Rue R, Mukhitov AR, Goel A, Basil MC, Obraztsova K, Babu A, Crnkovic S, Ledwell O, Ferguson LT, Planer JD, Nottingham AN, Vanka KS, Smith CJ, Cantu III E, Kwapiszewska G, Morrisey EE, Evans JF, Krymskaya VP.: Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling. J Clin Invest 134(4): e178116, Mar 2024.
Evans JF, McCormack FX, Sonenberg N, Krymskaya VP.: Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis. Eur Respir Rev 32: 230100, Sep 2023. Eur Respir Rev 32(1): 230100, Sep 2023.
Evans JF, Obraztsova K, Lin SM, Krymskaya VP: CrossTORC and Wntegration in disease: Focus on Lymphangioleiomyomatosis. International Journal of Molecular Sciences 22(5): 2233-2248, Feb 2021.
Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP: mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline. Nature Communications 11(1): 5640-5642, Nov 2020.
Jilly F. Evans, Ryan W. Rue, Alexander R. Mukhitov, Kseniya Obraztsova, Carly J. Smith, Vera P. Krymskaya
: Inhibition of Growth of TSC2-Null Cells by a PI3K/mTOR Inhibitor but Not by a Selective MNK1/2 Inhibitor
Biomolecules 10(1): 28, Jan 2020.
Obraztsova K, Evans JF and Krymskaya VP.: Syndecan-2: Old player in a new field. Am J Respir Cell Mol Biol 60(1): 611-612, Jan 2019.
Blanca E. Himes, Kseniya Obraztsova, Lurong Lian, Maya Shumyatcher, Ryan Rue, Elena N. Atochina-Vasserman, Stella K. Hur, Marisa S. Bartolomei, Jilly F. Evans, Vera P. Krymskaya: Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells
PLoS One. 13(5): e0197105, May 2018.
back to top
Last updated: 10/21/2025
The Trustees of the University of Pennsylvania
