My research currently focuses on adoptive T cell transfer, specifically the development of chimeric antigen receptor CAR T cells for use in solid tumors. The major areas of my interest have been augmentation of CAR T cells anti-tumor immune effects by optimizing CAR design, targeting the tumor microenvironment, improving T cell trafficking, and preventing T cell exhaustion.
Selected Publications
Noguera-Ortega E, Albelda SM.: Small cell, big promises: targeting small cell lung cancer with CAR T cells. Transl Lung Cancer Res 13: 956-960, Apr 2024.
Tilsed CM, Sadiq BA, Papp TE, Areesawangkit P, Kimura K, Noguera-Ortega E, Scholler J, Cerda N, Aghajanian H, Bot A, Mui B, Tam Y, Weissman D, June CH, Albelda SM, Parhiz H.: IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation. Proc Natl Acad Sci U S A 121: e2319856121, Mar 2024.
Lee IK, Sharma N, Noguera-Ortega E, Liousia M, Baroja ML, Etersque JM, Pham J, Sarkar S, Carreno BM, Linette GP, Puré E, Albelda SM, Sellmyer MA.: A genetically encoded protein tag for control and quantitative imaging of CAR T cell therapy. Mol Ther 31: 3564-3578, Dec 2023.
Lee K.I., Noguera-Ortega E., Xiao Z., Todd L., Scholler J., Song D., Liousia M., Lohith K., Xu K., Edwards K.J., Farwell M.D., June C.H, Albelda S.M, Pure E, Sellmyer M.A. : FAP CAR T cell therapy for solid tumors with PET imaging. AACR Special Conference on Tumor Immunology and Immunotherapy, Boston, USA, 2022 Oct 2023 Notes: poster session.
Lee K.I., Noguera-Ortega E., Xiao Z., Todd L., Scholler J., Song D., Liousia M., Lohith K., Xu K., Edwards K.J., Farwell M.D., June C.H, Albelda S.M, Pure E, Sellmyer M.A. : Monitoring FAP CAR T Cell Therapy with PET Imaging. ASGCT 26th Annual Meeting, Los Angeles, USA Sep 2023 Notes: poster session.
Zebin Xiao, Leslie Todd, Li Huang, Estela Noguera-Ortega, Zhen Lu, Lili Huang, Meghan Kopp, Yue Li, Nimisha Pattada, Wenqun Zhong, Wei Guo, John Scholler, Maria Liousia, Charles-Antoine Assenmacher, Carl H June, Steven M Albelda, Ellen Puré: Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors. Nature Communications 14: 5110, Aug 2023.
Jung IY, Noguera-Ortega E, Bartoszek R, Collins SM, Williams E, Davis M, Jadlowsky JK, Plesa G, Siegel DL, Chew A, Levine BL, Berger SL, Moon EK, Albelda SM, Fraietta JA.: Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors. Cell Rep Med 4: 101053, Jun 2023.
Sandra Guallar-Garrido, Víctor Campo-Pérez, Míriam Pérez-Trujillo, Cecilia Cabrera, Jordi Senserrich, Alejandro Sánchez-Chardi, Rosa Maria Rabanal, Elisabet Gómez-Mora, Estela Noguera-Ortega, Marina Luquin, Esther Julián: Mycobacterial surface characters remodeled by growth conditions drive different tumor-infiltrating cells and systemic IFN-γ/IL-17 release in bladder cancer treatment. OncoImmunology Dec 2022.
Iris K Lee, Estela Noguera-Ortega, Zebin Xiao, Leslie Todd, John Scholler, Decheng Song, Maria Liousia, Katheryn Lohith, Kexiang Xu, Kimberly J Edwards, Michael D Farwell, Carl H June, Steven M Albelda, Ellen Puré, Mark A Sellmyer: Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74. Clinical Cancer Research 28: 5330-5342, Dec 2022.
Noguera-Ortega E., Todd L., Monslow J., Liousia M., Sun J., Albelda S.M., Puré E.: Optimizing a FAP-CAR T cell for clinical trials. XVth Congress of the Catalan Society of Immunology: Advanced Immunotherapies Virtual Jun 2022 Notes: Oral presentation.
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Last updated: 04/04/2025
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