D. kacy Cullen - Faculty Biosketch

D. Kacy Cullen, Ph.D.

Professor of Neurosurgery

Member, Penn Center for Brain Injury & Repair, University of Pennsylvania

Principal Investigator, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

Member, Penn Center for Musculoskeletal Disorders, School of Medicine, University of Pennsylvania

Member, Institute of Regenerative Medicine, School of Medicine, University of Pennsylvania

Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania

Member, Institutional Animal Care and Use Committee, Philadelphia VA Medical Center

Director, Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA

Director, Translational Tissue Engineering & Regenerative Medicine (T-TERM) Fellowship Program, Dept. of Veterans Affairs & University of Pennsylvania

Director, Porcine Neurointensive Care and Assessment Facility (NCAF), Perelman School of Medicine, Department of Neurosurgery, University of Pennsylvania

Department: Neurosurgery

Graduate Group Affiliations

Contact information

Department of Neurosurgery
University of Pennsylvania School of Medicine
105 Hayden Hall / 3320 Smith Walk
Philadelphia, PA 19104

Office: 215-746-8176
Fax: 215-573-3808

Email:
dkacy@pennmedicine.upenn.edu

Education:
B.S. (Mechanical Engineering)
Georgia Institute of Technology, 2000.
M.S. (Mechanical Engineering)
Georgia Institute of Technology, 2002.
Ph.D. (Biomedical Engineering)
Georgia Institute of Technology, 2005.

Links
Cullen Lab Website
Traumatic Brain Injury Resource Guide
National Neurotrauma Society
Brain Injury Association
Society for Neuroscience
Biomedical Engineering Society
Center for Brain Injury & Repair, University of Pennsylvania
American Society for Mechanical Engineers

Post-Graduate Training
Post-Doctoral Researcher in Neural Engineering, Laboratory for Neuroengineering, Department of Biomedical Engineering, Georgia Institute of Technology, 2005-2006.
Post-Doctoral Fellow (NRSA) in Neurotrauma and Neural Engineering, Center for Brain Injury and Repair, Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania , 2007-2008.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Adewole, D. O., Struzyna, L. A., Harris, J. P., Nemes, A. D., Burrell, J. C., Petrov, D., Kraft, R. H., Chen, H. I., Serruya, M. D., Wolf, J. A., Cullen, D. K.: Development of optically-controlled "living electrodes" with long-projecting axon tracts for a synaptic brain-machine interface Science Advances 7(4): eaay5347, Jan 2021.

Keating, C. E., Browne, K. D., Cullen, D. K. : Dietary manipulation of vulnerability to traumatic brain injury-induced neuronal plasma membrane permeability. Experimental Neurology 340: 113649, Jun 2021.

Katiyar, K. S., Struzyna, L. A. (co-first author), Morand, J. P., Burrell, J. C., Clements, B., Laimo, F. A., Browne, K. D., Kohn, J., Ali, Z., Ledebur, H. C., Smith, D. H., Cullen, D. K.: Tissue engineered axon tracts serve as living scaffolds to accelerate axonal regeneration and functional recovery following peripheral nerve injury in rats. Frontiers in Biotechnology & Bioengineering 8: 492, May 2020.

Das, S., Browne, K. D., Laimo, F. A., Maggiore, J. C., Hilman M. C., Kaiser, H., Aguilar, C. A., Ali, Z. S., Mourkioti, F., Cullen, D. K.: Pre-innervated tissue engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss. Nature Communications Biology 3(1): 330, Jun 2020.

Grovola, M. R., Paleologos, N., Wofford, K. L., Harris, J. P., Browne, K. D., Johnson, V. E., Duda, J. E., Wolf, J. A., Cullen, D. K. : Mossy cell hypertrophy and synaptic changes in the hilus following mild diffuse brain injury in pigs. J Neuroinflammation 17(1): 44, 2020.

Keating, C. E. and Cullen, D. K. : Mechanosensation in traumatic brain injury. Neurobiology of Disease 148: 105210, Jan 2021.

Maggiore, J. C., Burrell, J. C. (co-first author), Browne, K. D., Katiyar, K. S., Laimo, F. A., Zarina, A. S., Kaplan, H. M., Rosen, J. M., Cullen, D. K.: Tissue engineered axon-based “living scaffolds” promote survival of spinal cord motor neurons following peripheral nerve repair. J Tissue Engin & Regen Med 14(12): 1892-1907, Dec 2020.

Das, S., Gordián-Vélez, W. (co-first author), Ledebur, H. C., Mourkioti, F., Rompolas, P., Chen, H. I., Serruya, M. D., Cullen, D. K. : Innervation: the missing link for biofabricated tissues and organs. npj Regenerative Medicine 5: 11, Jun 2020.

Cullen, D. K., Gordián-Vélez, W. J., Struzyna, L. A., Jgamadze, D., Lim, J., Wofford, K. L., Browne, K. D., Chen, H. I.: Bundled three-dimensional human axon tracts derived from cerebral organoids. iScience 21: 57-67, Nov 2019.

Struzyna, L. A., Browne, K. D., Brodnik, Z. D., Burrell, J. C., Harris, J. P., Chen, H. I., Wolf, J. A., Panzer, K. V., Lim, J., Duda, J. E., España, R. A., Cullen, D. K.: Tissue engineered nigrostriatal pathway for treatment of Parkinson’s disease. J Tissue Engin & Regen Med 12(7): 1702-16, Jul 2018.