Richard Aplenc, MD, PhD, MSCE
Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Colket Translational Research Building
Suite 4060
3501 Civic Center Blvd
Philadelphia, PA 19104
Suite 4060
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: 267-426-7252
Email:
aplenc@email.chop.edu
aplenc@email.chop.edu
Education:
A.B. (Classics)
Princeton University, 1988.
University of Pennsylvania, Post-Baccalaureate Pre-Health Program, 1989.
MD
University of Virginia, 1994.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, 2002.
PhD (Epidemiology)
University of Pennsylvania, 2011.
Permanent linkA.B. (Classics)
Princeton University, 1988.
University of Pennsylvania, Post-Baccalaureate Pre-Health Program, 1989.
MD
University of Virginia, 1994.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, 2002.
PhD (Epidemiology)
University of Pennsylvania, 2011.
Selected Publications
Miller TP, Getz KD, Krause E, Jo YG, Charapala S, Gramatges MM, Rabin K, Scheurer ME, Wilkes JJ, Fisher BT, Aplenc R: Erratum: Automated Electronic Health Record Data Extraction and Curation Using ExtractEHR. JCO Clin Cancer Inform Page: e2500013, Feb 2025 Notes: doi: 10.1200/CCI-25-00013.Jadlowsky JK, Hexner EO, Marshall A, Grupp SA, Frey NV, Riley JL, Veloso E, McConville H, Rogal W, Czuczman C, Hwang W, Li Y, Leskowitz RM, Farrelly O, Karar J, Christensen S, Barber-Rotenberg J, Gaymon A, Aronson N, Bernstein W, Melenhorst JJ, Roche AM, Everett JK, Zolnoski SA, McFarland AG, Reddy S, Petrichenko A, Cook EJ, Lee C, Gonzalez VE, Alexander K, Kulikovskaya I, Ramirez-Fernandez A, Minehart JC, Ruella M, Gill SI, Schuster SJ, Cohen AD, Garfall AL, Shah PD, Porter DL, Maude SL, Levine BL, Siegel DL, Chew A, McKenna S, Lledo L, Davis MM, Plesa G, Herbst F, Stadtmauer EA, Tebas P, DiNofia A, Haas A, Haas NB, Myers R, O'Rourke DM, Svoboda J, Tanyi JL, Aplenc R, Jacobson JM, Ko AH, Cohen RB, June CH, Bushman FD, Fraietta JA: Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies. Nat Med. Online ahead of print, Jan 2025 Notes: doi: 10.1038/s41591-024-03478-6.
Friedes BD, DiNofia AM, Iannone E, Li Y, Rheingold SR, Leahy AB, Wray L, Callahan C, Baniewicz D, Vernau L, Getz KD, Aplenc R, Maude SL, Grupp SA, Myers RM: Therapies and outcomes following extramedullary relapse of pediatric and young adult ALL after CD19 CAR T-cell therapy. Blood Adv 9(2): 354-359, Jan 2025 Notes: doi: 10.1182/bloodadvances.2024014518.
Bhagwat AS, Torres L, Shestova O, Shestov M, Mellors PW, Fisher HR, Farooki SN, Frost BF, Loken MR, Gaymon AL, Frazee D, Rogal W, Frey N, Hexner EO, Luger SM, Loren AW, Martin ME, McCurdy SR, Perl AE, Stadtmauer EA, Brogdon JL, Fraietta JA, Hwang W, Siegel DL, Plesa G, Aplenc R, Porter DL, Hune CH, Gill SI: Cytokine-mediated CAR T therapy resistance in AML. Nat Med 30(12): 3697-3708, Dec 2024 Notes: doi: 10.1038/s41591-024-03271-5.
Lamba J, Marchi F, Landwehr M, Schade A, Shastri V, Ghavami M, Sckaff F, Marrero R, Nguyen N, Mansinghka V, Cao X, Slayton W, Starostik P, Ribeiro R, Rubnitz J, Klco J, Gamis A, Triche Jr T, Ries R, Kolb EA, Aplenc R, Alonzo T, Pounds S, Meshinchi S, Cogle C, Elsayed A: Long-read epigenomic diagnosis and prognosis of Acute Myeloid Leukemia. Res Sq. Preprint, Dec 2024 Notes: doi: 10.21203/rs.3.rs-5450972/v1.
Miller TP, Getz KD, Krause E, Jo YG, Charapala S, Gramatages MM, Rabin K, Scheurer ME, Wilkes JJ, Fisher BT, APlenc R: Automated Electronic Health Record Data Extraction and Curation Using ExtractEHR. JCO Clin Cancer Inform Page: e2400100, Nov 2024 Notes: doi: 10.1200/CCI.24.00100.
Shoag J, Li Y, Getz KD, Huang Y, Hall M, Naranjo A, Richardson T, Desai AV, Umaretiya PJ, Aziz-Bose R, Kelly CA, Zheng DJ, Newman H, Zahler S, Aplenc R, Bagatell R, Bona K: Healthcare utilization disparities among children with high-risk neuroblastoma treated on Children's Oncology Group clinical trials. Pediatr Blood Cancer 71(10): e31192, Oct 2024 Notes: doi: 10.1002/pbc.31192.
Driessen A, Unger S, Nguyen A, Ries RE, Meshinchi S, Kreutmair S, Alberti C, Sumazin P, Aplenc R, Redell MS, Becher B, Martinez MR: Identification of single-cell blasts in pediatric acute myeloid leukemia using an autoencoder. Life Sci Alliance 7(11): e202402674, Aug 2024 Notes: doi: 10.26508/lsa.202402674.
Teachey D, Newman H, Lee S, Polonen P, Shraim R, Li Y, Liu H, Aplenc R, Bandyopadhyay S, Chen C, Chen Z, Devidas M, Diorio C, Dunsmore K, Elghawy O, Elhachimi A, Fuller T, Gupta S, Hall J, Hughes A, Hunger S, Loh M, Martinez Z, McCoy M, Mullen C, Pounds S, Raetz E, Ryan T, Seffernick A, Shi G, Sussman J, Tan K, Uppuluri L, Vincent TL, Wang'ondu R, Winestone L, Winter S, Wood B, Wu G, Xu J, Yang W, Mullighan C, Yang J, Bona K: Impact of Genetic Ancestry on T-cell Acute Lymphoblastic Leukemia Outcomes. Res Sq. Preprint, Aug 2024 Notes: doi: 10.21203/rs.3.rs-4858231/v1.
Elsayed AH, Cao X, Marrero RJ, Nguyen NH, Wu H, Ni Y, Ribeiro RC, Tobias H, Valk PJ, Beliveau F, Richard-Carpentier G, Hebert J, Zwaan CM, Gamis A, Kolb EA, Aplenc R, Alonzo TA, Meshinchi S, Rubnitz J, Pounds S, Lamba JK: Integrated drug resistance and leukemic stemness gene-expression scores predict outcomes in large cohort of over 3500 AML patients from 10 trials. NPJ Precis Oncol 8(1): 168, Aug 2024 Notes: doi: 10.1038/s41698-024-00643-5.