faculty photo

Sean Hennessy, PharmD, PhD

Professor of Epidemiology in Biostatistics and Epidemiology
Department: Biostatistics and Epidemiology

Contact information
University of Pennsylvania
3600 Civic Center Boulevard
4W-105C
Philadelphia, PA 19104-3413
Office: 215-898-9112
Education:
BS (Pharmacy)
Philadelphia College of Pharmacy and Science, 1989.
PharmD (Clinical Pharmacy)
Philadelphia College of Pharmacy and Science, 1990.
MSCE (Clinical Epidemiology)
University of Pennsylvania School of Medicine, 1996.
PhD (Epidemiology with Biostatistics minor)
University of Pennsylvania, 2002.
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Selected Publications

Thelen HE, Yang W, Hennessy S, Cohen J, Guo W, Miano T: Comparison of disease risk score methods to study treatment effect heterogeneity: a simulation study. American Journal of Epidemiology 2026 (doi:10.1093/aje/kwag050).

Chu PY, Kelly A, Hennessy S, Vajravelu ME, Huang J, Amaral S: GLP-1RA dispensing in youth With type 2 diabetes: 2020 to 2023. Pediatrics Page: e2025071971, 2026.

Vo T-T1, Roy S, Ye T, Erterfaie A, Pham Nguyen TP, Flory J, Leonard CE, Small DS and Hennessy S: Effect of exogenous testosterone on cardiovascular, cerebrovascular, and thromboembolic adverse events: Results of three complementary research designs. American Journal of Epidemiology 2025 (https://doi.org/10.1093/aje/kwaf098).

Mahoney KM, Bravo L, McAllister A, Bogar K, Hennessy S, Schreiber CA, Abernathy A: Reproductive health services in abortion-providing clinics: A scoping review of provision and policy contexts. Women's Health Issues 2025 (https://doi.org/10.1016/j.whi.2025.07.007).

Meng LC, Leonard CE, Candon M, Mandell DS, Hennessy S: Trends in psychotropic medication use, polypharmacy, and potential major drug-drug interactions among US youth. Journal of the American Academy of Child & Adolescent Psychiatry 2025 (doi:10.1016/j.jaac.2025.12.006).

Rothstein A, Khazaal O, Messe S, Liu Y, Hennessy S, Chen Y, Algra A, Uchiyama S, Poli S, Geisler T, Serna Higuita LM, Perera K, Taylor A, Kasner SE: Switching from aspirin monotherapy after noncardioembolic stroke: A systematic review and network meta-analysis. Stroke 2025 (doi: 10.1161/STROKEAHA.125.053030).

Hsu Y-C, Thakrar AP, Leonard CE, Lowenstein M, Brensinger CM, Bilker WB, Bogar KF, Hennessy S: Trends in methadone use for pain and opioid use disorder among Medicaid enrollees. JAMA Health Forum 6: e244023, 2025.

Srivastava T, Harris RA, Bettigole C, Zhang H, Brensinger CM, Bogar K, Wang F, Nesoff ED, Bilker WB, Hennessy S: Stimulant overdose prediction model for Medicaid-insured persons. JAMA Health Forum 6: e253489, 2025.

Dublin S, Albertson-Junkans L, Pham Nguyen TP, Pavon JM, Hastings SN, Maciejewski ML, Willis A, Zepel L, Hennessy S, Albers KB, Mowery D, Clark AG, Thomas S, Steinman MA, Boyd CM, Bayliss EA: Defining key deprescribing measures from electronic health data: A multisite data harmonization project. Journal of the American Geriatrics Society 2024 (https://doi.org/10.1111/jgs.19280).

Zhang H, Miano TA, Bilker WB, Leonard CE, Hennessy S: Grace periods and exposure misclassification in self-controlled case-series studies of drug-drug interactions. American Journal of Epidemiology 2024 (https://doi.org/10.1093/aje/kwae231).

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Last updated: 03/10/2026
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