faculty photo

Adam Christian Naj, PhD

Assistant Professor of Epidemiology in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Department: Biostatistics and Epidemiology

Contact information
921 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: (215) 746-4180
Fax: (215) 573-1050
Lab: (215) 746-4180
Education:
BA (Biology (Genetics)/Psychology)
University of Chicago, 2000.
PhD (Epidemiology (Human Genetics))
The Johns Hopkins University Bloomberg School of Public Health, 2008.
Permanent link
 
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Selected Publications

Leung YY, Naj AC, Chou YF, Valladares O, Schmidt M, Hamilton-Nelson K, Wheeler N, Lin H, Gangadharan P, Qu L, Clark K, Kuzma AB, Lee WP, Cantwell L, Nicaretta H; Alzheimer’s Disease Sequencing Project; Haines J, Farrer L, Seshadri S, Brkanac Z, Cruchaga C, Pericak-Vance M, Mayeux RP, Bush WS, Destefano A, Martin E, Schellenberg GD, Wang LS: Human Whole-Exome Genotype Data for Alzheimer's Disease. Nature Communications 15: 684, January 2024.

Wang H, Chang TS, Dombroski BA, Cheng PL, Patil V, Valiente-Banuet L, Farrell K, Mclean C, Molina-Porcel L, Rajput A, De Deyn PP, Bastard NL, Gearing M, Kaat LD, Van Swieten JC, Dopper E, Ghetti BF, Newell KL, Troakes C, de Yébenes JG, Rábano-Gutierrez A, Meller T, Oertel WH, Respondek G, Stamelou M, Arzberger T, Roeber S, Müller U, Hopfner F, Pastor P, Brice A, Durr A, Ber IL, Beach TG, Serrano GE, Hazrati LN, Litvan I, Rademakers R, Ross OA, Galasko D, Boxer AL, Miller BL, Seeley WW, Van Deerlin VM, Lee EB, White CL, Morris H, de Silva R, Crary JF, Goate AM, Friedman JS, Leung YY, Coppola G, Naj AC, Wang LS; PSP genetics study group; Dickson DW, Höglinger GU, Schellenberg GD, Geschwind DH, Lee WP.: Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy. medRxiv January 2024.

Eissman JM, Archer DB, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj AC, Gifford KA; Alzheimer's Disease Neuroimaging Initiative (ADNI) | Alzheimer's Disease Genetics Consortium (ADGC) | The Alzheimer's Disease Sequencing Project (ADSP); Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang LS, Schellenberg GD, Mayeux RP, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Hohman TJ, Dumitrescu L.: Sex-specific genetic architecture of late-life memory performance. Alzheimer's & Dementia November 2023 Notes: Online ahead of print; DOI: 10.1002/alz.13507.

Farrell K, Humphrey J, Chang T, Zhao Y, Leung YY, Kuksa PP, Patil V, Lee W-P, Kuzma AB, Valladares O, Cantwell LB, Wang H, Ravi A, De Sanctis C, Han N, Christie TD, Whitney K, Krassner MM, Walsh H, Kim SH, Dangoor D, Iida MA, Casella A, Walker RH, Nirenberg MJ, Renton AE, Babrowicz B, Coppola G, Raj T, Höglinger GU, Golbe LI, Morris HR, Hardy J, Revesz T, Warner TT, Jaunmuktane Z, Mok KY, Rademakers R, Dickson DW, Ross OA, Wang L-S, Goate A, Schellenberg G, Geschwind DH, PSP Genetics Study Group, Crary JF, Naj A: Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes. bioRxiv November 2023 Notes: doi: https://doi.org/10.1101/2023.11.09.565552.

Archer DB, Eissman JM, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj AC, Gifford KA; Alzheimer's Disease Neuroimaging Initiative (ADNI); Alzheimer's Disease Genetics Consortium (ADGC); Alzheimer's Disease Sequencing Project (ADSP); Cuccaro ML, Pericak-Vance MA, Farrer LA, Wang LS, Schellenberg GD, Mayeux RP, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Dumitrescu L, Hohman TJ.: Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease. Alzheimer's & Dementia November 2023 Notes: Online ahead of print; DOI: 10.1002/alz.13508.

Zhang X, Gomez L, Below J, Naj A, Martin E, Kunkle B, Bush WS.: An X Chromosome Transcriptome Wide Association Study Implicates ARMCX6 in Alzheimer's Disease. bioRxiv October 2023.

Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Schellenberg GD, Destefano AL, Haines JL, Peloso GM.: Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project. medRxiv September 2023.

Katsumata Y, Fardo DW, Shade LMP; Alzheimer’s Disease Genetics Consortium; Nelson PT.: LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry. Journal of Neuropathology and Experimental Neurology 82: 760-768, August 2023.

Li L, Wu Q, Lundin SK, Naj AC, Gur RC, Rascovsky K, Wolk DA, Tao C, Chen Y: Investigating drug repurposing for the prevention of Alzheimer’s disease and related dementias using electronic health records in the University of Pennsylvania Health System. Alzheimer's Association International Conference (AAIC), Amsterdam, Netherlands July 2023 Notes: Poster presentation.

Li YJ, Nuytemans K, La JO, Jiang R, Slifer SH, Sun S, Naj A, Gao XR, Martin ER.: Identification of novel genes for age-at-onset of Alzheimer's disease by combining quantitative and survival trait analyses. Alzheimer's & Dementia 19(7): 3148-3157, July 2023.

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Last updated: 02/12/2024
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