Adam Christian Naj, PhD
Associate Professor of Epidemiology in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Department: Biostatistics and Epidemiology
Graduate Group Affiliations
Contact information
921 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
423 Guardian Drive
Philadelphia, PA 19104
Office: (215) 746-4180
Fax: (215) 573-1050
Lab: (215) 746-4180
Fax: (215) 573-1050
Lab: (215) 746-4180
Email:
adamnaj@mail.med.upenn.edu
adamnaj@mail.med.upenn.edu
Publications
Education:
BA (Biology (Genetics)/Psychology)
University of Chicago, 2000.
PhD (Epidemiology (Human Genetics))
The Johns Hopkins University Bloomberg School of Public Health, 2008.
BA (Biology (Genetics)/Psychology)
University of Chicago, 2000.
PhD (Epidemiology (Human Genetics))
The Johns Hopkins University Bloomberg School of Public Health, 2008.
Links
Search PubMed for articles
Google Scholar
Research Gate
Collaborator Page for the National Human Genome Research Institute (NHGRI) Alzheimer's Disease Sequencing Project (ADSP)
Penn Neurodegeneration Genomics Center
NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS)
Permanent linkSearch PubMed for articles
Google Scholar
Research Gate
Collaborator Page for the National Human Genome Research Institute (NHGRI) Alzheimer's Disease Sequencing Project (ADSP)
Penn Neurodegeneration Genomics Center
NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS)
Selected Publications
Bledsoe X, Wang TC, Wu Y, Archer D, Chen HH, Naj AC, Bush WS, Hohman TJ, Dumitrescu L, Below JE, Gamazon ER.: Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's disease. Alzheimer's & Dementia February 2026.Durant A, Mukherjee S, Lee ML, Choi SE, Scollard P, Klinedinst BS, Trittschuh EH, Mez J, Farrer LA, Gifford KA, Cruchaga C, Hassenstab J, Naj AC, Wang LS, Johnson SC, Engelman CD, Kukull WA, Keene CD, Saykin AJ, Cuccaro ML, Kunkle BW, Pericak-Vance MA, Martin ER, Bennett DA, Barnes LL, Schneider JA, Bush WS, Haines JL, Mayeux R, Vardarajan BN, Albert MS, Thompson PM, Jefferson AL; Alzheimer's Disease Neuroimaging Initiative (ADNI)*Alzheimer's Disease Genetics Consortium (ADGC)The Alzheimer's Disease Sequencing Project (ADSP); Crane PK, Dumitrescu L, Archer DB, Hohman TJ, Gaynor LS.: Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers. Alzheimer's & Dementia February 2026.
Li YJ, La JO, Naj A, Martin ER.: Leveraging genetic propensity to identify modifiable factors for the age at onset of Alzheimer's disease. Alzheimer's & Dementia February 2026.
Contreras AG, Walters S, Eissman JM, Archer DB, Regelson AN, Durant A, Clifton M, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez J, Bush WS, Kunkle BW, Cruchaga C, Naj AC, Gifford KA, Bilgel M, Kuzma AB; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer’s Disease Genetics Consortium (ADGC); Alzheimer’s Disease Sequencing Project (ADSP); Cuccaro ML, Pericak-Vance MA, Farrer LA, Wang LS, Schellenberg GD, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Albert MS, Johnson SC, Engelman CD, Ferrucci L, Bennett DA, Barnes LL, Schneider JA, Sperling RA, Resnick SM, Crane PK, Dumitrescu L, Hohman TJ.: Genetic modifiers of APOE-ε4-associated cognitive decline. Nature Communications February 2026.
Jin Y, Wang H, Naj AC, Wang LS, Lee WP.: GrafAnc: Reliable and reproducible inference of continental and regional population structure. HGG Advances 7: 100530, January 2026.
Wang D, Abbruzzese S, Heard-Costa N, Rampersaud A, Martin E, Naj A, Akgun B, Kunkle B, Seshadri S, Peloso G; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Disease Sequencing Project; DeStefano AL, Li Z, Li X, Choi SH.: Application of the STAAR framework in detecting rare variant associations with Alzheimer disease and related dementias: Insights and implications. HGG Advances 7: 100574, January 2026.
Durodoye RO, Ciesielski TH, Benchek P, Bartlett J, Zhu X, Liu S, Naj A, Kunkle B, Schellenberg GD, Mayeux R, Farrer L, Wang LS, Pericak-Vance MA, Rajabli F, Tosto G, Haines JL, Bush WS, Williams SM.: Deviations from additivity in APOE4-mediated late-onset Alzheimer's disease risk across races and ethnicities. Human Genetics 145: 16, January 2026.
Cholerton B, Godrich D, Pasteris J, Rivero J, Martin ER, Kunkle BW, Naj AC, Hamilton-Nelson KL, Wang H, Lee WP, Dumitrescu L, Hohman TJ, Mayeux R, Larson EB, Crane PK, Keene CD, Latimer CS, Mukherjee S, Kofler JK, Kamboh MI, Bennett DA, Molina-Porcel L, Cuccaro M, Pericak-Vance MA, Rundek T, Scott WK, Kukull W, Schellenberg G; Alzheimer’s Disease Genetics Consortium; Beecham GW, Montine TJ.: Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort. medRxiv January 2026.
Rast JE, Rosso AL, James BD, Underwood JFG, Bergstedt J, Ahlqvist VH, Grove J, Fang F, Goldstein ND, Vivanti G, Levine SZ, Nordström A, Schendel D, Lyall K, Nordström P, Ballin M, Stafford J, Naj AC, Lee BK; LEGENNDS Consortium.: Association of neurodevelopmental conditions with Alzheimer's disease and related dementias and Parkinson's disease. Journal of Gerontology Series A: Biological Sciences and Medical Sciences December 2025.
Andersen OM, de Waal MWJ, Monti G, Tesi N, Jensen AMG, de Geus C, van Spaendonk R, Vogel M, Ahmad S, Amin N, Amouyel P, Beecham GW, Bellenguez C, Berr C, Bis JC, Boland A, Bossù P, Bouwman F, Bras J, Charbonnier C, Clarimon J, Cruchaga C, Daniele A, Dartigues JF, Debette S, Deleuze JF, Denning N, DeStefano AL, Dols-Icardo O, van Duijn CM, Farrer LA, Fernández MV, van der Flier WM, Fox NC, Galimberti D, Genin E, Gille JJP, Grenier-Boley B, Grozeva D, Guen YL, Guerreiro R, Haines JL, Holmes C, Hummerich H, Arfan Ikram M, Kamran Ikram M, Kawalia A, Kraaij R, Lambert JC, Lathrop M, Lemstra AW, Lleó A, Myers RM, Mannens MMAM, Marshall R, Martin ER, Masullo C, Mayeux R, Mead S, Mecocci P, Meggy A, Mol MO, Nacmias B, Naj AC, Napolioni V, Nicholas Cochran J, Nicolas G, Pasquier F, Pastor P, Pericak-Vance MA, Pijnenburg YAL, Piras F, Quenez O, Ramirez A, Raybould R, Redon R, Reinders MJT, Richard AC, Riedel-Heller SG, Rivadeneira F, van Rooij JGJ, Rousseau S, Ryan NS, Sanchez-Juan P, Schellenberg GD, Scheltens P, Schott JM, Seshadri S, Sie D, Sims R, Sistermans EA, Sorbi S, van Swieten JC, Tijms B, Uitterlinden AG, Visser PJ, Wagner M, Wallon D, Wang LS, Williams J, et al.: Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer's disease. Molecular Neurodegeneration 20: 122, December 2025.