CENT is part of a national Rehabilitation Research Infrastructure coalition funded by the National Center for Medical Rehabilitation Research of NICHD, NIH. CENT utilizes the resources of The University of Pennsylvania (PENN), to study neural plasticity and repair from the level of genes to complex neural systems to the human brain and spinal cord. The purpose is to translate studies of basic mechanisms of plasticity and repair into rehabilitative therapies for CNS injury. Collaborators and trainees will gain access to the most advanced in vivo imaging techniques, from in vivo micro-imaging (including two-photon, confocal, micro-MRI, micro-CT, micro-PET, micro-SPECT, optical infrared imaging) to human functional imaging (MRI, SPECT, PET, NMR spectroscopy, diffusion tensor imaging). The CENT faculty comprises expertise in these imaging modalities, as well as brain mapping, gait analysis, clinical trials in motor retraining, axonal regeneration, glial and stem cell biology, neuronal assemblies and systems approaches and bi-directional translation between bench and clinical trials.

Michael E. Selzer, MD, PhD, FRCP Director, CENT Department of Neurology University of Pennsylvania School of Medicine 3400 Spruce Street Philadelphia, PA 19104-4283 USA Tel: (215) 898-0180; Fax: (215) 573-2107 email: cent@uphs.upenn.edu http://www.med.upenn.edu/ins/faculty /selzer.html

John A. Detre, MD Departments of Neurology and Radiology Director, Center for Functional Neuroimaging (CFN) University of Pennsylvania School of Medicine 3400 Spruce Street Philadelphia, PA 19104-4283 USA Tel: (215) 349-8465; Fax: (215) 614-1927 email: detre@mail.med.upenn.edu http://cfn.upenn.edu/