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Our Center

The Penn Frontotemporal Degeneration Center brings together an energetic team of creative clinicians and researchers dedicated to the investigation and treatment of early onset neurodegenerative conditions.   Our Center members include neurologists, neuropathologists, neuroscientists, geneticists, genetic counselors, neuropsychologists, nurses, social workers, and clinical research coordinators, all targeting a cure for Frontotemporal degeneration .

The Penn Frontotemporal Degeneration Center  also enjoys rich collaborations with colleagues within the University of Pennsylvania such as the Center for Neurodegenerative Disease Research, the Institute on Aging, and the Penn Image Computing and Science Lab.  Research partners outside of the University of Pennsylvania include Washington University in St. Louis, Emory University, Brandeis University, Johns Hopkins University, and the Mayo Clinic. 

Intellectual diversity, creativity and strong collaborative partnerships uniquely position the Penn Frontotemporal Degeneration Center to deliver the highest quality of care to our patients, conduct translational research to improve diagnostic and prognostic accuracy, improve understanding of the biological basis of Frontotemporal degeneration spectrum disorders, and train the next generation of physicians and researchers as we move toward a cure.

Mission

The Penn Frontotemporal Degeneration Center  brings together an interdisciplinary team of clinicians and researchers dedicated to the treatment and investigation of early onset neurodegenerative conditions. 

History

Dr. Murray Grossman started his career in cognitive neurology and neuroscience while training at the Boston Aphasia Research Center in the 1970s.  After completing a post-doctoral fellowship at the Massachusetts Institute of Technology (MIT), Dr. Grossman attended McGill University for his medical training.  Dr. Grossman moved to the University of Pennsylvania for his neurology residency in 1986 and has since been building a diverse laboratory.  Dr. Grossman’s research has been instrumental in the field of Cognitive Neurology and neurodegenerative disease.  He is internationally recognized as a world-leader in Frontotemporal degeneration  (FTD) and is ranked among the top 100 Alzheimer’s disease (AD) researchers by the Journal of Alzheimer’s Disease. 

Center Research

The Penn Frontotemporal Degeneration Center  learns a great deal about Frontotemporal degeneration by studying patients who have been diagnosed with an FTD spectrum disorder. Our National Institutes of Health funded research studies for patients as well as healthy volunteers include predictive genetics, neuroimaging, neurocognitive testing and the collection of biomarkers, including blood and cerebrospinal fluid. This work contributes to diagnostic accuracy, prognosis and treatment trials.

People

A strength of the Penn Frontotemporal Degeneration Center is its diverse team of clinicians and researchers who dedicate their energy, expertise and creativity to the investigation and treatment of early onset neurodegenerative conditions.   Our Center members include neurologists, neuropathologists, neuroscientists, geneticists, genetic counselors, neuropsychologists, nurses, social workers, and clinical research coordinators, all targeting a cure for frontotemporal degeneration.  The Penn Frontotemporal Degeneration Center is actively training the next generation of neurologists and neuroscientists.

Through the Eyes of the Caregiver: Frontotemporal Degeneration (FTD) and the Penn FTD Center

Frontotemporal degeneration (FTD) is a debilitating neurodegenerative disease that dramatically affects the lives of both the patient and their loved ones. Hear the stories of three dedicated FTD caregivers and their experience with the Penn Frontotemporal Degeneration Center.

The early age of onset of many FTD disorders and the changes in behavior and language that can accompany them can make living with FTD a challenge for both caregivers and patients. Resources are available to support the unique needs of each patient and their caregivers. 

 

 

PENN FRONTOTEMPORAL DEGENERATION CENTER RESEARCHERS

Areas Of Expertise

The research expertise at the Penn FTD Center  spans many levels of neuroscience ranging from detailed clinico-pathological studies, biomarker discovery, genetics, neuropsychological studies, functional and structural neuroimaging, and cognitive neuroscience investigations of language, memory, and social cognition. 

Publications

Recent Center publications have spanned such topics as white matter imaging in tauopathy forms of FTD, ALS genetic markers, and criteria for the diagnosis of primary progressive aphasia and behavioral variant FTD.   

Training and Career Opportunities

The Penn FTD Center provides an excellent training environment for undergraduate students, graduate students, clinical fellows, and research fellows to facilitate the education of the next generation of world-leading Frontotemporal degeneration  experts.

Diversity Statement

The Penn FTD Center strongly affirms diversity and inclusiveness in our center, in the families we serve, in the University of Pennsylvania, and in biomedical research.  We recognize that justice requires that we at the FTDC work to better defend and reflect the diversity of race, religion, ethnicity, sexual orientation, gender identity and national origin that enriches our community.  We abhor the division and violence that deny the full humanity of all members of our society.  Please see our full statement.

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