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The Penn Frontotemporal Degeneration Center learns a great deal about Frontotemporal degeneration by studying patients who have been diagnosed with a Frontotemporal degeneration spectrum disorder. Our National Institutes of Health funded research studies for patients as well as healthy volunteers include predictive genetics, neuroimaging, neurocognitive testing and the collection of biomarkers, including blood and cerebrospinal fluid. This work contributes to diagnostic accuracy, prognosis and treatment trials.