The Functional Genomics Core  (FGC) of the Penn Diabetes Research Center

The FGC provides state-of-the-art experiment planning, sample preparation, quality assessment, library construction, DNA sequencing, and data analysis services to DRC members.  We are currently operating five state-of-the-art Illumina Sequencers. We have experience with ChIP-seq, nucleosome mapping, miRNA, and genome resequencing in mouse, human, zebrafish, and other species. We offer RNAseq, microRNAseq, GroSeq, CLIP-seq, nucleosome mapping, ATAC-Seq, ChIPseq, Exome sequencing, whole genome and targeted methylome analysis, hydroxymethyl DIP, and single cell RNAseq. A second goal of the FGC is to quickly adapt and occasionally develop new protocols for sequencing-based functional genomics analysis relevant to DRC members.

For Next Generation Sequencing Core Services, please contact the Technical Director of the Core, Dr. Jonathan Schug - or

For complex Computational and Bioinformatics Support Services only available to DRC members, please contact Dr. KJ Won -  Services include but are not limited to complex transcriptome analysis of mRNA and miRNA gene expression, analysis of miRNA to mRNA targeting relationships, cistrome and methylome analysis and their integration, analysis of allele-specific gene expression and transcription factor binding, and analysis of nascent transcripts obtained by GroSeq.

Please acknowledge services provided by the FGC in your publications as follows:

"We thank the University of Pennsylvania Diabetes Research Center (DRC) for the use of the Functional Genomics Core (P30-DK19525)."

Jonathan Schugg, Technical Director

Technical Director Next Generation Sequencing Core
Dr. Jonathan Schug

KJ Won

Dr. K-J Won
Bioinformatics Support