List of Current Trials

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PIs

Study Title

Penn Rodebaugh Diabetes Center Trials

Andrea Kelly, MD, MSCE & Michael Rickels, MD, MS

Determination of Beta-Cell Responsiveness to the Incretin Hormones GLP-1 and GIP in Cystic Fibrosis
Andrea Kelly, MD, MSCE & Michael Rickels, MD, MS Emergence and Progression of Abnormal Glucose Tolerance in Cystic Fibrosis
Andrea Kelly, MD, MSCE & Michael Rickels, MD, MS Effects of GLP-1 Agonist Therapy on Insulin Secretion in Adults with Pancreatic Insufficient Cystic Fibrosis and Abnormal Glucose Tolerance: a randomized, open-label, cross-over trial
Ali Naji, MD & Michael Rickles, MD, MS A Phase 1/2 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-880 in
Subjects Who Have Type 1 Diabetes Mellitus with Impaired Hypoglycemic
Awareness and Severe Hypoglycemia
Michael Rickels, MD, MS A phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of 400 mg twice a day oral ladarixin in patients with new-onset type 1 diabetes and a low residual ╬▓-cell function at baseline
Michael Rickels, MD, MS Automated Insulin Delivery in Elderly with Type 1 Diabetes (AIDE T1D): A Randomized Cross-over Trial Evaluating Automated Insulin Delivery Technologies on Hypoglycemia and Quality of Life in Elderly Adults with Type 1 Diabetes

Mark Schutta, MD

Epidemiology of Diabetes Interventions and Complications Study (EDIC STUDY)

Penn Bone Center Trials

Felix Wehrli, PhD Bone Water and Mineralization Measured by Nuclear Magnetic Resonance

Penn Metabolic Medicine Trials

Anastastia Amaro, MD A Prospective, Randomized, Double-Blind, Sham- Controlled, Multi-Center Pivotal Study to Evaluate the Efficacy and Safety of Duodenal Mucosal Resurfacing Using the Revita® System in Subjects with Type 2 Diabetes on Insulin therapy
Kelly Allison, PhD Meal Timing and Metabolism Study
Zoltan P. Arany, M.D., Ph.D., Michael R. Rickels, MD., MS Investigation of the Effect of Branched Chain Amino Acids on Fat-Induced Insulin Resistance in Healthy Adults

David Merrick, MD, PhD

Human Metabolic Tissue Bank

Penn Pituitary Center Trials

Peter Snyder, MD A Randomized, Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of Paltusotine in Subjects with Acromegaly Treated with Long-acting Somatostatin Receptor Ligands

Penn Thyroid Center Trials

Anne Cappola, MD, MS

Ghrelin Plus Resistance Training in Frail Elderly Study