Penn Center for Myeloproliferative Neoplasms

Welcome to MPN!

The Penn Center for Myeloproliferative Neoplasms and Mast Cell Disorders is a nationally recognized program providing comprehensive clinical care for patients with myeloproliferative neoplasms, including systemic mast cell disorders. We work hard to enable access to the latest clinical trials, and to serve as an educational resource for patients and healthcare providers. 

Myeloproliferative neoplasms are rare blood disorders, which can be challenging to diagnose and nuanced to treat. Since Penn's discovery of the Philadelphia Chromosome, which revolutionized treatment of chronic myeloid leukemia, Penn has led the way in treatment of myeloproliferative disorders. Under the guidance of Dr. Elizabeth Hexner, Penn has established a comprehensive team of expert hematologists, hematopathologists, molecular diagnostics specialists, bone marrow transplant physicians, advanced practice nurses and pharmacists who work together to develop a personalized treatment plan drawing upon decades of experience.

Penn MPN and Mast Cell Disorders Program Physicians treat all types of myeloproliferative disorders, including:

• Acute Leukemia arising from MPN
• Chronic Eosinophilic Leukemia
• Chronic Myeloid Leukemia
• Essential Thrombocythemia
• Myelofibrosis
• Myeloproliferative/Myelodysplastic Syndromes
• Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB OR FGFR1
• Polycythemia Vera
• Systemic Mastocytosis