Paul A. Offit

faculty photo
Maurice R. Hilleman Chair of Vaccinology
Department: Pediatrics
Graduate Group Affiliations

Contact information
Division of Infectious Diseases
Abramson Research Building, Room 1202D
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: (215) 590-2020
Fax: (215) 590-2025
Tufts University , 1973.
University of Maryland, 1977.
Permanent link

Description of Research Expertise

Research Interests
rotavirus, rotavirus vaccine, intestinal immunity, vaccines, vaccine safety

Key words: rotavirus, rotavirus vaccine, intestinal immunity.

Description of Research
We studied the genetics of rotavirus virulence, rotavirus neutralization phenotype and protein-specificities of rotavirus-specific cytotoxic T lymphocytes as a prelude to making a bovine-human reassortant rotavirus vaccine. The vaccine, RotaTeq, was licensed by the Food and Drug Administration in February, 2006.

Rotation Projects for 2006-2007
None. The laboratory closed in December, 2005. My professional time is devoted to running the Vaccine Education Center at the Children’s Hospital of Philadelphia: an international center that creates educational materials for parents and healthcare professionals and runs on an endowment yielding about $500,000 per year.

Selected Publications

Offit, P.A. and Hackett, C.J. : Addressing parents’ concerns: Do vaccines cause allergic or autoimmune diseases? Pediatrics 111: 653-659, 2003.

Chow, A.A., Moser C.A., Speaker, T.J., and Offit, P.A. : Determination of efficiency of attachment of biotinylated antibodies to avidin-linked, aqueous-based microcapsules by flow cytometry. J. Immunol. Methods 277: 135-139, 2003.

Offit, P.A., Jew, R.K.: Addressing parents’ concerns: Do vaccines contain harmful preservatives, adjuvants, additives, or residuals? Pediatrics [in press] 2003.

Offit, P.A. and Coffin, S.E. : Communicating science to the public: MMR vaccine and autism. Vaccine [in press] 2003.

Offit, PA, HF Clark, and RL Ward. : Current state of development of human rotavirus vaccines. Viral Gastroenteritis. U. Desselberger and J. Gray (eds.). Elsevier Science BV, Amsterdam, The Netherlands, Page: 345-356, 2003.

Ward RL, HF Clark, PA Offit, and RI Glass.: Live vaccine strategies to prevent rotavirus disease. New Generation Vaccines. M.M. Levine, G.C. Woodrow, J.B. Kaper, and G.S. Cobon (eds.). Marcel Dekker, Inc., New York, NY, in press 2003.

Clark, H F., P.A. Offit, R.I. Glass, and RM Ward. : Rotavirus vaccines. Vaccines, 4th Edition. S.A.Plotkin and W. Orenstein (eds.). W.B. Saunders in press 2003.

Offit P.A., and C.J. Hackett. : Do vaccines weaken, overwhelm, or alter the normal balance of the immune system. Vaccines, 4th Edition. S.A.Plotkin and W. Orenstein (eds.). W.B. Saunders in press 2003.

Offit, PA. : Getting "fully informed" about vaccines. Contemp. Pediatr. in press 2003.

Offit, P.A.: The power of 'box a'. Expert Rev Vaccines 2: 1-3, 2003.

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Last updated: 09/30/2015
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