Paul A. Offit

faculty photo
Maurice R. Hilleman Chair of Vaccinology
Department: Pediatrics
Graduate Group Affiliations

Contact information
Division of Infectious Diseases
Abramson Research Building, Room 1202D
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: (215) 590-2020
Fax: (215) 590-2025
Tufts University , 1973.
University of Maryland, 1977.
Permanent link

Description of Research Expertise

Research Interests
rotavirus, rotavirus vaccine, intestinal immunity, vaccines, vaccine safety

Key words: rotavirus, rotavirus vaccine, intestinal immunity.

Description of Research
We studied the genetics of rotavirus virulence, rotavirus neutralization phenotype and protein-specificities of rotavirus-specific cytotoxic T lymphocytes as a prelude to making a bovine-human reassortant rotavirus vaccine. The vaccine, RotaTeq, was licensed by the Food and Drug Administration in February, 2006.

Rotation Projects
None. The laboratory closed in December, 2005. My professional time is devoted to running the Vaccine Education Center at the Children’s Hospital of Philadelphia: an international center that creates educational materials for parents and healthcare professionals and runs on an endowment yielding about $500,000 per year.

Selected Publications

Offit, P.A. and Hackett, C.J. : Addressing parents’ concerns: Do vaccines cause allergic or autoimmune diseases? Pediatrics 111: 653-659, 2003.

Chow, A.A., Moser C.A., Speaker, T.J., and Offit, P.A. : Determination of efficiency of attachment of biotinylated antibodies to avidin-linked, aqueous-based microcapsules by flow cytometry. J. Immunol. Methods 277: 135-139, 2003.

Offit, P.A., Jew, R.K.: Addressing parents’ concerns: Do vaccines contain harmful preservatives, adjuvants, additives, or residuals? Pediatrics [in press] 2003.

Offit, P.A. and Coffin, S.E. : Communicating science to the public: MMR vaccine and autism. Vaccine [in press] 2003.

Offit, PA, HF Clark, and RL Ward. : Current state of development of human rotavirus vaccines. Viral Gastroenteritis. U. Desselberger and J. Gray (eds.). Elsevier Science BV, Amsterdam, The Netherlands, Page: 345-356, 2003.

Ward RL, HF Clark, PA Offit, and RI Glass.: Live vaccine strategies to prevent rotavirus disease. New Generation Vaccines. M.M. Levine, G.C. Woodrow, J.B. Kaper, and G.S. Cobon (eds.). Marcel Dekker, Inc., New York, NY, in press 2003.

Clark, H F., P.A. Offit, R.I. Glass, and RM Ward. : Rotavirus vaccines. Vaccines, 4th Edition. S.A.Plotkin and W. Orenstein (eds.). W.B. Saunders in press 2003.

Offit P.A., and C.J. Hackett. : Do vaccines weaken, overwhelm, or alter the normal balance of the immune system. Vaccines, 4th Edition. S.A.Plotkin and W. Orenstein (eds.). W.B. Saunders in press 2003.

Offit, PA. : Getting "fully informed" about vaccines. Contemp. Pediatr. in press 2003.

Offit, P.A.: The power of 'box a'. Expert Rev Vaccines 2: 1-3, 2003.

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Last updated: 11/23/2015
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