Jason D. Christie, MD, MSCE

faculty photo
Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
717 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Education:
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Christie's translational research studies involve the role of oxidative stress, coagulation/fibrinolysis and inflammatory pathways in acute lung injury following lung transplantation (termed primary graft dysfunction); somatic genetic variation; gene expression; and protein biomarkers in the etiology and pathogenesis of acute lung injury in the transplant, sepsis, and trauma populations.

Selected Publications

Shah R J, Diamond J M, Cantu E, Flesch J, Lee J C, Lederer D J, Lama V N, Orens J, Weinacker A, Wilkes D S, Roe D, Bhorade S, Wille K M, Ware L B, Palmer S M, Crespo M, Demissie E, Sonnet J, Shah A, Kawut S M, Bellamy S L, Localio A R, Christie J D: Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation. American Journal of Transplantation epub ahead of print, Apr 2015.

Sayah DM, Mallavia B, Liu F, Ortiz-Muñoz G, Caudrillier A, DerHovanessian A, Ross DJ, Lynch III JP, Saggar R, Ardehali A, Ware LB, Christie JD, Belperio JA, Looney MR: Neutrophil Extracellular Traps Are Pathogenic in Primary Graft Dysfunction After Lung Transplantation. American Journal of Respiratory and Critical Care Medicine 191(4): 455-463, Apr 2015.

Ortego A, Gaieski DF, Fuchs BD, Jones T, Halpern SD, Small DS, Sante SC, Drumheller B, Christie JD, Mikkelsen ME: Hospital-Based Acute Care Use in Survivors of Septic Shock. Crit Care Med 43(4): 729-737, Apr 2015.

Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP: Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. Human Molecular Genetics 24(6): 1801-12, Mar 2015.

Whittaker Stacey-Ann, Fuchs Barry D, Gaieski David F, Christie Jason D, Goyal Munish, Meyer Nuala J, Kean Craig, Small Dylan S, Bellamy Scarlett L, Mikkelsen Mark E: Epidemiology and outcomes in patients with severe sepsis admitted to the hospital wards. Journal of critical care 30(1): 78-84, Feb 2015.

Cantu E, Shah RJ, Lin W, Daye ZJ, Diamond JM, Suzuki Y, Ellis JH, Borders CF, Andah GA, Beduhn B, Meyer NJ, Ruschefski M, Aplenc R, Feng R, Christie JD: Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation. The Journal of Thoracic and Cardiovascular Surgery 149(2): 596-602, Feb 2015.

Eberlein M, Reed RM, Bolukbas S, Diamond JM, Wille KM, Orens JB, Brower RG, Christie JD: Lung size mismatch and primary graft dysfunction after bilateral lung transplantation. The Journal of Heart and Lung Transplantation 34(2): 233-240, Feb 2015.

Young J C, Chehoud C, Bittinger K, Bailey A, Diamond J M, Cantu E, Haas A R, Abbas A, Frye L, Christie J D, Bushman F D, Collman R G: Viral metagenomics reveal blooms of anelloviruses in the respiratory tract of lung transplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15(1): 200-9, Jan 2015.

Singer Jonathan P, Peterson Eric R, Snyder Mark E, Katz Patricia P, Golden Jeffrey A, D'Ovidio Frank, Bacchetta Matthew, Sonett Joshua R, Kukreja Jasleen, Shah Lori, Robbins Hilary, Van Horn Kristin, Shah Rupal J, Diamond Joshua M, Wickersham Nancy, Sun Li, Hays Steven, Arcasoy Selim M, Palmer Scott M, Ware Lorraine B, Christie Jason D, Lederer David J: Body composition and mortality after adult lung transplantation in the United States. American journal of respiratory and critical care medicine 190(9): 1012-21, Nov 2014.

Bittinger K, Charlson ES, Loy E, Shirley DJ, Haas AR, Laughlin A, Yi Y, Wu GD, Lewis JD, Frank I, Cantu E, Diamond JM, Christie JD, Collman RG, Bushman FD: Improved characterization of medically relevant fungi in the human respiratory tract using next-generation sequencing. Genome Biol 15(10): Epub ahead of print, Oct 2014.

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Last updated: 07/27/2015
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