Edward B Lee, MD, PhD

faculty photo
Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
605B Stellar Chance Laboratories
422 Curie Blvd
Philadelphia, PA 19104
Office: 215-898-0908
Lab: 215-662-6696
Education:
BS (Biological Sciences)
Stanford University, 1997.
PhD (Neuroscience)
University of Pennsylvania School of Medicine, 2004.
MD
University of Pennsylvania School of Medicine, 2005.
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Description of Research Expertise

Alzheimer's disease
Frontotemporal lobar degeneration
Amyotrophic lateral sclerosis

Selected Publications

Lee Edward B, Warmann Genevieve, Dhir Ravindra, Ahima Rexford S: Metabolic dysfunction associated with adiponectin deficiency enhances kainic Acid-induced seizure severity. The Journal of neuroscience : the official journal of the Society for Neuroscience 31(40): 14361-6, Oct 2011.

Igaz Lionel M, Kwong Linda K, Lee Edward B, Chen-Plotkin Alice, Swanson Eric, Unger Travis, Malunda Joe, Xu Yan, Winton Matthew J, Trojanowski John Q, Lee Virginia M-Y: Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of clinical investigation 121(2): 726-38, Feb 2011.

Lee Edward B, Lee Virginia M-Y, Trojanowski John Q, Neumann Manuela: TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system. Acta neuropathologica 115(3): 305-11, Mar 2008.

Lee Edward B, Tihan Tarik, Scheithauer Bernd W, Zhang Paul J, Gonatas Nicholas K: Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker? Journal of neuropathology and experimental neurology 68(5): 482-8, May 2009.

Lim Youngshin, Kehm Victoria M, Lee Edward B, Soper James H, Li Chi, Trojanowski John Q, Lee Virginia M-Y: α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. The Journal of neuroscience : the official journal of the Society for Neuroscience 31(27): 10076-87, Jul 2011.

Winton Matthew J, Lee Edward B, Sun Eveline, Wong Margaret M, Leight Susan, Zhang Bin, Trojanowski John Q, Lee Virginia M-Y: Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience 31(21): 7691-9, May 2011.

Lee Edward B, Skovronsky Daniel M, Abtahian Farhad, Doms Robert W, Lee Virginia M-Y: Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons. The Journal of biological chemistry 278(7): 4458-66, Feb 2003.

Lee Edward B, Leng Lewis Z, Zhang Bin, Kwong Linda, Trojanowski John Q, Abel Ted, Lee Virginia M-Y: Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. The Journal of biological chemistry 281(7): 4292-9, Feb 2006.

Lee Edward B, Zhang Bin, Liu Kangning, Greenbaum Eric A, Doms Robert W, Trojanowski John Q, Lee Virginia M-Y: BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. The Journal of cell biology 168(2): 291-302, Jan 2005.

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Last updated: 01/13/2014
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