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Edward B Lee, MD, PhD
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Professor of Pathology and Laboratory Medicine
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Department: Pathology and Laboratory Medicine
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Graduate Group Affiliations
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- Pharmacology 64
- Neuroscience 6b
- Cell and Molecular Biology e
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Contact information
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613A Stellar Chance Laboratories
31 422 Curie Blvd
Philadelphia, PA 19104
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31 422 Curie Blvd
Philadelphia, PA 19104
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Office: 215-898-0908
3e Lab: 215-662-6696
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3e Lab: 215-662-6696
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Education:
21 7 BS 20 (Biological Sciences) c
2c Stanford University, 1997.
21 8 PhD 19 (Neuroscience) c
46 University of Pennsylvania School of Medicine, 2004.
21 7 MD c
46 University of Pennsylvania School of Medicine, 2005.
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Permanent link21 7 BS 20 (Biological Sciences) c
2c Stanford University, 1997.
21 8 PhD 19 (Neuroscience) c
46 University of Pennsylvania School of Medicine, 2004.
21 7 MD c
46 University of Pennsylvania School of Medicine, 2005.
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29 Frontotemporal lobar degeneration
24 Amyotrophic lateral sclerosis
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Description of Research Expertise
24 Alzheimer's disease29 Frontotemporal lobar degeneration
24 Amyotrophic lateral sclerosis
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1e0 Igaz Lionel M*, Kwong Linda K*, Lee Edward B*, Chen-Plotkin Alice, Swanson Eric, Unger Travis, Malunda Joe, Xu Yan, Winton Matthew J, Trojanowski John Q, Lee Virginia M-Y: Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of clinical investigation 121(2): 726-38, Feb 2011 Notes: *Lionel M Igaz, Linda K Kwong and Edward B Lee are co-lead authors.
158 Liu Elaine Y, Russ Jenny, Wu Kathryn, Neal Donald, Suh Eunran, McNally Anna G, Irwin David J, Van Deerlin Vivianna M, Lee Edward B: C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD. Acta neuropathologica 128(4): 525-41, Oct 2014.
1c6 Russ Jenny, Liu Elaine Y, Wu Kathryn, Neal Donald, Suh EunRan, Irwin David J, McMillan Corey T, Harms Matthew B, Cairns Nigel J, Wood Elisabeth M, Xie Sharon X, Elman Lauren, McCluskey Leo, Grossman Murray, Van Deerlin Vivianna M, Lee Edward B: Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier. Acta neuropathologica 129(1): 39-52, Jan 2015.
15e McMillan Corey T, Russ Jenny, Wood Elisabeth M, Irwin David J, Grossman Murray, McCluskey Leo, Elman Lauren, Van Deerlin Vivanna, Lee Edward B: C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence. Neurology 84(16): 1622-30, Apr 2015.
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Selected Publications
fc Lee Edward B, Lee Virginia M-Y, Trojanowski John Q: Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nature reviews. Neuroscience 13(1): 38-50, Nov 2011.1e0 Igaz Lionel M*, Kwong Linda K*, Lee Edward B*, Chen-Plotkin Alice, Swanson Eric, Unger Travis, Malunda Joe, Xu Yan, Winton Matthew J, Trojanowski John Q, Lee Virginia M-Y: Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of clinical investigation 121(2): 726-38, Feb 2011 Notes: *Lionel M Igaz, Linda K Kwong and Edward B Lee are co-lead authors.
158 Liu Elaine Y, Russ Jenny, Wu Kathryn, Neal Donald, Suh Eunran, McNally Anna G, Irwin David J, Van Deerlin Vivianna M, Lee Edward B: C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD. Acta neuropathologica 128(4): 525-41, Oct 2014.
1c6 Russ Jenny, Liu Elaine Y, Wu Kathryn, Neal Donald, Suh EunRan, Irwin David J, McMillan Corey T, Harms Matthew B, Cairns Nigel J, Wood Elisabeth M, Xie Sharon X, Elman Lauren, McCluskey Leo, Grossman Murray, Van Deerlin Vivianna M, Lee Edward B: Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier. Acta neuropathologica 129(1): 39-52, Jan 2015.
15e McMillan Corey T, Russ Jenny, Wood Elisabeth M, Irwin David J, Grossman Murray, McCluskey Leo, Elman Lauren, Van Deerlin Vivanna, Lee Edward B: C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence. Neurology 84(16): 1622-30, Apr 2015.
2c