Allan I. Pack, M.B.Ch.B., Ph.D., FRCP

faculty photo
John Miclot Professor
Department: Medicine
Graduate Group Affiliations

Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
Permanent link

Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Selected Publications

Naidoo, N., Zhu, J., Galante, R.J., Lian, J., Strus, E., Lee, A., Keenan, B.T., and Pack, A.I.: Reduction of the molecular chaperone binding immunoglobulin protein (BiP) accentuates the effect of aging on sleep-wake behavior. Neurobiology of Aging 69: 10-25, Sep 2018.

Feng, Y., Keenan, B.T., Wang, S., Leinwand, S., Wiemken, A., Pack, A.I. and Schwab R.J.: Dynamic upper airway imaging during wakefulness in obese subjects with and without sleep apnea. American Journal of Respiratory and Critical Care Medicine Jul 2018 Notes: doi: 10.1164/rccm.201711-2171OC. [Epub ahead of print]

Mazzotti, D., Lim, D., Sutherland, K., Bittencourt, L., Mindel, J., Magalang, U., Pack, A., de Chazal, P. and Penzel, T.: Opportunities for utilizing polysomnography signals to personalize obstructive sleep apnea management. Physiological Measurement Jul 26 2018 Notes: doi: 10.1088/1361-6579/aad5fe. [Epub ahead of print]

Pak, V.M., Mazzotti, D.R., Keenan, B.T., Hirotsu, C., Gehrman, P., Bittencourt, L., Pack, A.I. and Tufik, S.: Candidate gene analysis in the Sao Paulo Epidemiological Sleep Study (EPISONO) shows an association of variant in PDE4D and sleepiness. Sleep Medicine 47: 106-112, Jul 2018.

Perron, I.J., Keenan, B.T., Chellappa, K., Lahens, N.F., Yohn, N.L., Shockley, K.R., Pack, A.I. and Veasey, S.C.: Dietary challenges differentially affect activity and sleep/wake behavior in mus musculus: isolating independent associations with diet/energy balance and body weight. PLoS One 13(5): e0196743, May 10 2018.

Pak, V.M., Dai, F., Keenan, B.T., Gooneratne, N.S. and Pack, A.I.: Lower plasma choline levels are associated with sleepiness symptoms. Sleep Medicine 44: 89-96, Apr 2018.

Kim, J., Keenan, B.T., Lim, D.C., Lee, S.K., Pack, A.I. and Shin, C.: Symptom-based subgroups of Koreans with obstructive sleep apnea. Journal of Clinical Sleep Medicine 14(3): 437-443, Mar 15 2018.

Younes, M., Kuna, S.T., Pack, A.I., Walsh, J.K., Kushida, C.A., Staley, B., and Pien, G.W.: Reliability of the American Academy of Sleep Medicine rules for assessing depth in clinical practice. Journal of Clinical Sleep Medicine 14(2): 205-2013, Feb 2018.

Pien, G.W., Ye, L., Keenan, B.T., Maislin, G., Bjornsdottir, E., Arnardottir, E.S., Benediktsdottir, B., Gislason, T. and Pack, A.I.: Changing faces of OSA: treatment effects by cluster designation in the Icelandic Sleep Apnea Cohort. Sleep Jan 2018 Notes: doi: 10.1093/sleep/zsx201. [Epub ahead of print]

Keenan, B.T., Kim, J., Singh, B, Bittencourt, L., Chen, N.H., Cistulli, P.A., Magalang, U., McArdle, N., Mindel, J.W., Benediktsdottir, B., Arnardottir, E.S., Prochnow, L.K., Penzel, T., Sanner, B., Schwab, R., Shin, C., Sutherland, K., Tufik, S., Maislin, G., Gislason, T. and Pack, A.I.: Recognizable clinical subtypes of OSA across a worldwide sleep center population: a cluster analysis. Sleep Jan 2018 Notes: 2018 Jan 5. doi: 10.1093/sleep/zsx214. [Epub ahead of print]

back to top
Last updated: 08/14/2018
The Trustees of the University of Pennsylvania