19
1
49
2
8
1b
1d
18
43
3a
1d
2 29
1d
25
Allan I. Pack, M.B.Ch.B., Ph.D., FRCP
78
3a
John Miclot Professor
7
5f
Department: Medicine
4
1
23
1f
Graduate Group Affiliations
8
a
b
1d
46
Contact information
51
4
3
3
1d
51
Translational Research Laboratories
49 125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
26
49 125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
2e
Office: 215-746-4806
32 Fax: 215-746-4814
24
97
32 Fax: 215-746-4814
24
Email:
PACK@PENNMEDICINE.UPENN.EDU
12
PACK@PENNMEDICINE.UPENN.EDU
18
Publications
23 a
3
2
29
23 a
Links
96 Search PubMed for articles
3e Neuroscience graduate group faculty webpage.
62 Primary Work Website
c
4
b
1f
96 Search PubMed for articles
3e Neuroscience graduate group faculty webpage.
62 Primary Work Website
c
13
Education:
21 d M.B.Ch.B c
38 University of Glasgow, Scotland, 1967.
21 a Ph.D. 31 (Mathematical models of lung function) c
38 University of Glasgow, Scotland, 1976.
c
3
3
3
3
90
Permanent link21 d M.B.Ch.B c
38 University of Glasgow, Scotland, 1967.
21 a Ph.D. 31 (Mathematical models of lung function) c
38 University of Glasgow, Scotland, 1976.
c
2 29
21
1e
1d
24
5e
e 29
27
Description of Research Expertise
380 Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs three training grants from the National Institutes of Health.e 29
23
151 Keenan, B. T., Strus, E., Lin, R., Chan, M., Lian, J., Galante, R., Worley, P., Pack, A. I., & Naidoo, N.: Mutant mouse models implicate a role for mGluR1/5, prolyl isomerase (Pin1) and Homer1a interactions in wakefulness. Frontiers in neuroscience September 2025.
211 Kurniansyah N, Strausz SJ, Chittoor G, Gupta S, Justice AE, Hrytsenko Y, Keenan BT, Cade BE, Spitzer BW, Wang H, Huffman J, Moll MR, Haring B, Jung SY, Raffield LM, Kaplan R, Rotter JI, Rich SS, Gharib SA, Bartz TM, Liu PY, Chen H, Fornage M, Hou L, Levy D, Morrison AC, Ochs-Balcom HM, Psaty BM, Wilson PWF, Cho K, Pack AI, Ollila HM, Redline S, Gottlieb DJ, Sofer T: Polygenic scores for obstructive sleep apnoea reveal pathways. EBioMedicine July 2025.
187 Imamura, T., Wasilczuk, A. Z., Reitz, S. L., Lian, J., Imamura, M., Keenan, B. T., Shimizu, N., Pack, A. I., & Kelz, M. B.: Parafacial GABAergic neurone ablation induces behavioural resistance to volatile anaesthetic-induced hypnosis without reducing sleep. British journal of anaesthesia 134(6): 1696-1708, June 2025.
163 Xu, L., Keenan, B. T., Wiemken, A. S., Staley, B., Benediktsdottir, B., Juliusson, S., Pack, A. I., Gislason, T., & Schwab, R. J. : The Relationship between Upper Airway Anatomy and Obesity in Patients with Obstructive Sleep Apnea. Annals of the American Thoracic Society June 2025.
1d3 Lee, R., Larson, O., Dhaliwal, S., Moon, K., Gerardy, B., de Chazal, P., Cistulli, P. A., Chen, N. H., Han, F., Li, Q. Y., Maislin, G., McArdle, N., Penzel, T., Schwab, R. J., Tufik, S., Magalang, U. J., Singh, B., Gislason, T., Pack, A. I., Keenan, B. T., …: Comparative analysis of sleep physiology using qualitative and quantitative criteria for insomnia symptoms. Sleep 48(3), March 2025.
142 Mazzotti, D. R., Magalang, U. J., Keenan, B. T., Mindel, J., Younes, M., Penzel, T., Pack, A. I., & de Chazal, P.: OSA symptom subtypes and hypoxic burden independently predict distinct cardiovascular outcomes. ERJ open research 11(1), January 2025.
14f Kneeland, E., Ali, N., Maislin, D. G., Chang, Y. H., Epelboim, J., Keenan, B. T., & Pack, A. I.: Achieving adherence to positive airway pressure in commercial drivers using an employer-mandated remote management programme. ERJ open research 10(6), November 2024.
1ea Sonti, S., Littleton, S.H., Pahl, M.C., Zimmerman, A.J., Chesi, A. Palermo, J., Lascni, C., Brown, E.B., Pippin, J.A., Wells, A.D., Doldur-Balli F., Pack, A.I., Gehrman, P.R., Keene, A.C., and Grant, S.F.A.: Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q. Sleep Page: zsae085, July 2024 Notes: doi: 10.1093/sleep/zsae085.
173 Xu, L., Yi, H., Pi, M., Zhang, C., Keenan, B.T., Glick, H.A., Dong, X., Pack, A.I., Han, F., and Kuna, S.T.: Telemedicine management of obstructive sleep apnea disorder in China: a randomized, controlled, non-inferiority trial. Sleep and Breathing June 2024 Notes: doi: 10.1007/s11325-024-02994-6.
2c
7
1d
1f
Selected Publications
192 Eysteinn Finnsson, Eydis Arnardottir, Kristofer Montazeri, Brendan T Keenan, Richard J Schwab, Thorarinn Gislason, Allan I Pack, Andrew Wellman, Anna S Islind, Jon S Agustsson, Scott A Sands: Respiratory Inductance Plethysmography to Quantify Changes in Ventilation in Obstructive Sleep Apnea. IEEE Trans Biomed Eng October 2025.151 Keenan, B. T., Strus, E., Lin, R., Chan, M., Lian, J., Galante, R., Worley, P., Pack, A. I., & Naidoo, N.: Mutant mouse models implicate a role for mGluR1/5, prolyl isomerase (Pin1) and Homer1a interactions in wakefulness. Frontiers in neuroscience September 2025.
211 Kurniansyah N, Strausz SJ, Chittoor G, Gupta S, Justice AE, Hrytsenko Y, Keenan BT, Cade BE, Spitzer BW, Wang H, Huffman J, Moll MR, Haring B, Jung SY, Raffield LM, Kaplan R, Rotter JI, Rich SS, Gharib SA, Bartz TM, Liu PY, Chen H, Fornage M, Hou L, Levy D, Morrison AC, Ochs-Balcom HM, Psaty BM, Wilson PWF, Cho K, Pack AI, Ollila HM, Redline S, Gottlieb DJ, Sofer T: Polygenic scores for obstructive sleep apnoea reveal pathways. EBioMedicine July 2025.
187 Imamura, T., Wasilczuk, A. Z., Reitz, S. L., Lian, J., Imamura, M., Keenan, B. T., Shimizu, N., Pack, A. I., & Kelz, M. B.: Parafacial GABAergic neurone ablation induces behavioural resistance to volatile anaesthetic-induced hypnosis without reducing sleep. British journal of anaesthesia 134(6): 1696-1708, June 2025.
163 Xu, L., Keenan, B. T., Wiemken, A. S., Staley, B., Benediktsdottir, B., Juliusson, S., Pack, A. I., Gislason, T., & Schwab, R. J. : The Relationship between Upper Airway Anatomy and Obesity in Patients with Obstructive Sleep Apnea. Annals of the American Thoracic Society June 2025.
1d3 Lee, R., Larson, O., Dhaliwal, S., Moon, K., Gerardy, B., de Chazal, P., Cistulli, P. A., Chen, N. H., Han, F., Li, Q. Y., Maislin, G., McArdle, N., Penzel, T., Schwab, R. J., Tufik, S., Magalang, U. J., Singh, B., Gislason, T., Pack, A. I., Keenan, B. T., …: Comparative analysis of sleep physiology using qualitative and quantitative criteria for insomnia symptoms. Sleep 48(3), March 2025.
142 Mazzotti, D. R., Magalang, U. J., Keenan, B. T., Mindel, J., Younes, M., Penzel, T., Pack, A. I., & de Chazal, P.: OSA symptom subtypes and hypoxic burden independently predict distinct cardiovascular outcomes. ERJ open research 11(1), January 2025.
14f Kneeland, E., Ali, N., Maislin, D. G., Chang, Y. H., Epelboim, J., Keenan, B. T., & Pack, A. I.: Achieving adherence to positive airway pressure in commercial drivers using an employer-mandated remote management programme. ERJ open research 10(6), November 2024.
1ea Sonti, S., Littleton, S.H., Pahl, M.C., Zimmerman, A.J., Chesi, A. Palermo, J., Lascni, C., Brown, E.B., Pippin, J.A., Wells, A.D., Doldur-Balli F., Pack, A.I., Gehrman, P.R., Keene, A.C., and Grant, S.F.A.: Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q. Sleep Page: zsae085, July 2024 Notes: doi: 10.1093/sleep/zsae085.
173 Xu, L., Yi, H., Pi, M., Zhang, C., Keenan, B.T., Glick, H.A., Dong, X., Pack, A.I., Han, F., and Kuna, S.T.: Telemedicine management of obstructive sleep apnea disorder in China: a randomized, controlled, non-inferiority trial. Sleep and Breathing June 2024 Notes: doi: 10.1007/s11325-024-02994-6.
2c