Robert J. Levy, MD

faculty photo
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
CHOP
Abramson Pediatric Research Center,
Room 702D
Philadelphia, PA 19104-4318
Office: 215-590-6119
Fax: 215-590-5454
Education:
M.D.
Johns Hopkins University School of Medicine, 1970.
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Description of Research Expertise

Research Summary
Heart Valve Disease: Research programs underway concerning the developmental basis for aortic valve disease, mechanistic studies of progression of calcific aortic stenosis, serotonin mechanisms in heart valve disease, and novel biomaterials for heart valve prostheses.

Gene delivery stents are an area of major interest: plasmid or viral vectors configured in sustained release preparations onto vascular stents for site specific vascular gene therapy.

Magnetic delivery of nanoparticles for pharmaceutical and cell therapy to treat arterial disease.

Selected Publications

Fishbein I, Guerrero DT, Alferiev IS, Foster JB, Minutolo NG, Chorny M, Monteys AM, Driesbaugh KH, Nagaswami C, Levy RJ: Stent-based delivery of adeno-associated viral vectors with sustained vascular transduction and iNOS-mediated inhibition of in-stent restenosis. Gene Ther Aug 2017.

Battig Mark R, Fishbein Ilia, Levy Robert J, Alferiev Ivan S, Guerrero David, Chorny Michael: Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system. Drug Deliv Transl Res Jul 2017 Notes: NIHMS897618.

Lee S, Levy RJ, Christian AJ, Hazen SL, Frick NE, Lai EK, Grau JB, Bavaria JE, Ferrari G.: Calcification and Oxidative Modifications Are Associated With Progressive Bioprosthetic Heart Valve Dysfunction. J Am Heart Assoc 6(5): pii: e005648. May 2017.

Goldberg E, Grau JB, Fortier JH, Salvati E, Levy RJ, Ferrari G.: Serotonin and catecholamines in the development and progression of heart valve diseases. Cardiovascular Research 2017 Notes: in press.

Fishbein I, Welch, Guerrero DT, Alferiev IS, Adamo RF, Chorny M, Gupte RK, Tang Y, Levy RJ: Paraffin Processing of Stented Arteries Using a Post-Fixation Dissolution of Metallic and Polymeric Stents. Cardiovascular Pathology 25(6): 483-488, Aug 2016.

Slee JB, Alferiev IS, Nagaswami C, Weisel JW, Levy RJ, Fishbein I, Stachelek SJ: Enhanced biocompatibility of CD47-functionalized vascular stents. Biomaterials 87: 82-92, May 2016.

Adamo Richard F, Fishbein Ilia, Zhang Kehan, Wen Justin, Levy Robert J, Alferiev Ivan S, Chorny Michael: Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries. J Control Release 222: 169-75, Jan 2016.

Christian AJ, Alferiev IS, Connolly JM, Ischiropoulos H, Levy RJ.: The effects of the covalent attachment of 3-(4-hydroxy-3,5-di-tertbutylphenyl) propyl amine to glutaraldehyde pre-treated bovine pericardium on structural degeneration, oxidative modification and calcification of rat subdermal implants. J Biomed Mater Res A 103(7): 2441-8, Jul 2015.

Alferiev Ivan S, Iyer Radhika, Croucher Jamie L, Adamo Richard F, Zhang Kehan, Mangino Jennifer L, Kolla Venkatadri, Fishbein Ilia, Brodeur Garrett M, Levy Robert J, Chorny Michael: Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials 51: 22-9, May 2015.

Iyer R, Croucher JL, Chorny M, Mangino JL, Alferiev IS, Levy RJ, Kolla V, Brodeur GM: Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma. Cancer Lett 360(2): 205-12, Feb 2015.

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Last updated: 11/16/2017
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