Robert J. Levy, MD

faculty photo
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
CHOP
Abramson Pediatric Research Center,
Room 702D
Philadelphia, PA 19104-4318
Office: 215-590-6119
Fax: 215-590-5454
Education:
M.D.
Johns Hopkins University School of Medicine, 1970.
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Description of Research Expertise

Research Summary
Heart Valve Disease: Research programs underway concerning the developmental basis for aortic valve disease, mechanistic studies of progression of calcific aortic stenosis, serotonin mechanisms in heart valve disease, and novel biomaterials for heart valve prostheses.

Gene delivery stents are an area of major interest: plasmid or viral vectors configured in sustained release preparations onto vascular stents for site specific vascular gene therapy.

Magnetic intravascular delivery of nanoparticles to treat arterial disease.

Selected Publications

Hood Elizabeth D, Chorny Michael, Greineder Colin F, S Alferiev Ivan, Levy Robert J, Muzykantov Vladimir R: Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation. Biomaterials 35(11): 3708-15, Apr 2014 Notes: [PubMed - in process]

Tengood JE, Alferiev IS, Zhang K, Fishbein I, Levy RJ, Chorny M.: Real-time disassembly analysis of composite magnetic nanoparticles in cells and biomimetic media. Proc Natl Acad Sci USA 11(11): 4245-50, Mar 2014 Notes: Pub Med in process.

Christian Abigail J, Lin Hongqiao, Alferiev Ivan S, Connolly Jeanne M, Ferrari Giovanni, Hazen Stanley L, Ischiropoulos Harry, Levy Robert J: The susceptibility of bioprosthetic heart valve leaflets to oxidation. Biomaterials 35(7): 2097-102, Feb 2014.

Fishbein I, Forbes SP, Adamo RF, Chorny M, Levy RJ, Alferiev IS. : Vascular gene transfer from metallic stent surfaces using adenoviral vectors tethered through hydrolysable cross-linkers. J Vis Exp 2014 Notes: in press. PubMed as supplied by publisher.

Finley Matthew J, Clark Katherine A, Alferiev Ivan S, Levy Robert J, Stachelek Stanley J: Intracellular signaling mechanisms associated with CD47 modified surfaces. Biomaterials 34(34): 8640-9, Nov 2013.

Forbes Scott P, Alferiev Ivan S, Chorny Michael, Adamo Richard F, Levy Robert J, Fishbein Ilia: Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: implications for gene therapy of restenosis. Atherosclerosis 230(1): 23-32, Sep 2013.

Forbes, Scott P., Alferiev, Ivan S., Chorny, Michael, Adamo, Richard F., Levy, Robert J., Fishbein, Ilia: Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: Implications for gene therapy of restenosis. Atherosclerosis 230(1): 23-32, Sep 2013.

Fishbein Ilia, Forbes Scott P, Chorny Michael, Connolly Jeanne M, Adamo Richard F, Corrales Ricardo A, Alferiev Ivan S, Levy Robert J: Adenoviral vector tethering to metal surfaces via hydrolyzable cross-linkers for the modulation of vector release and transduction. Biomaterials 34(28): 6938-48, Sep 2013.

Ma G, Wang Y, Fishbein I, Yu M, Zhang L, Alferiev IS, Yang J, Song C, Levy RJ: Anchoring of self-assembled plasmid DNA/ anti-DNA antibody/cationic lipid micelles on bisphosphonate-modified stent for cardiovascular gene delivery. Int J Nanomedicine 8: 1029-1035, March 2013.

Chorny Michael, Fishbein Ilia, Tengood Jillian E, Adamo Richard F, Alferiev Ivan S, Levy Robert J: Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors. FASEB J 27(6): 2198-206, Feb 2013.

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Last updated: 10/28/2014
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