Robert J. Levy, MD

faculty photo
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
CHOP
Abramson Pediatric Research Center,
Room 702D
Philadelphia, PA 19104-4318
Office: 215-590-6119
Fax: 215-590-5454
Education:
M.D.
Johns Hopkins University School of Medicine, 1970.
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Description of Research Expertise

Research Summary
Heart Valve Disease: Research programs underway concerning the developmental basis for aortic valve disease, mechanistic studies of progression of calcific aortic stenosis, serotonin mechanisms in heart valve disease, and novel biomaterials for heart valve prostheses.

Gene delivery stents are an area of major interest: plasmid or viral vectors configured in sustained release preparations onto vascular stents for site specific vascular gene therapy.

Magnetic delivery of nanoparticles for pharmaceutical and cell therapy to treat arterial disease.

Selected Publications

Frasca A, Xue Y, Kossar AP, Keeney S, Rock C, Zakharchenko A, Streeter M, Gorman RC, Grau JB, George I, Bavaria JE, Krieger A, Spiegel DA, Levy RJ, Ferrari G: Glycation and serum albumin infiltration contribute to the structural degeneration of bioprosthetic heart valves J Am Coll Cardiol Basic Trans Science Aug 05 2020 Notes: Epublished DOI:10.1016/j.jacbts.2020.06.008

Kossar Alexander P, Anselmo Wanda, Grau Juan B, Liu Yichuan, Small Aeron, Carter Samuel L, Salvador Lisa, Zhao Lei, Cvijic Mary Ellen, Li Zhuyin, Yarde Melissa, Rioux Nancy, Rader Daniel J, Levy Robert J, Ferrari Giovanni: Circulating and tissue matricellular RNA and protein expression in calcific aortic valve disease. Physiol Genomics. 52(4): 191-199, Apr 2020 Notes: PubMed Central in process.

Inamdar Vaishali V, Fitzpatrick Emmett, Alferiev Ivan, Nagaswami Chandrasekaran, Spruce Lynn A, Fazelinia Hossein, Bratinov George, Seeholzer Steven H, Levy Robert J, Fishbein Ilia, Stachelek Stanley J: Stability and bioactivity of pepCD47 attachment on stainless steel surfaces. Acta Biomaterialia 104: pii: S1742-7061(19)30882-7. Jan 2020.

Battig MR, Alferiev IS, Guerrero DT, Fishbein I, Pressly BB, Levy RJ, Chorny M: An Experimental Single-Platform Approach to Enhance Functionalization of Magnetically Targetable Cells. ACS Applied Bio Materials 2020 Notes: accepted; mt-2020-00466a.R1; DOI: 10.1021/acsabm.0c00466; NIHMS1597029.

Fortier JH, Pizzarotti B, Shaw RE, Levy RJ, Ferrari G, Grau J. : Drug-associated valvular heart diseases and serotonin-related pathways: a meta-analysis. Heart 105(15): 1140-1148, Aug 2019 Notes: Epub ahead of print. doi:10.1136/heartjnl-2018-314403.

Battig Mark R, Fishbein Ilia, Levy Robert J, Alferiev Ivan S, Guerrero David, Chorny Michael: Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system. Drug Deliv Transl Res 8(4): 954-963, Aug 2018 Notes: epub July 2017. Paper publication Aug 2018.

Anselmo W, Branchetti E, Grau JB, Li G, Ayoub S, Rioux N, Tovmasyan A, Sacks MS, Batinic-Haberle I, Levy RJ, Ferrari G: A Porphyrin-based SOD mimic, Mntnbuoe-2-pyp5+ inhibits mechanisms of aortic valve remodeling in human and murine models of aortic valve sclerosis. J Am Heart Assoc 2018 Notes: submitted April 2018; accepted for publication Aug 2018.

KH Driesbaugh; E Branchetti, JB Grau, SJ Keeney, K Glass, MA Oyama, J Fortier; N Rioux, MS Sacks J Quackenbush, RJ Levy, G Ferrari: Serotonin Receptor 2B Signaling with Interstitial Cell Activation and Leaflet Remodeling in Degenerative Mitral Regurgitation. J Mol Cell Cardiol. 115: 94-103, December 2017

Fishbein I, Guerrero DT, Alferiev IS, Foster JB, Minutolo NG, Chorny M, Monteys AM, Driesbaugh KH, Nagaswami C, Levy RJ: Stent-based delivery of adeno-associated viral vectors with sustained vascular transduction and iNOS-mediated inhibition of in-stent restenosis. Gene Ther Aug 2017.

Lee S, Levy RJ, Christian AJ, Hazen SL, Frick NE, Lai EK, Grau JB, Bavaria JE, Ferrari G.: Calcification and Oxidative Modifications Are Associated With Progressive Bioprosthetic Heart Valve Dysfunction. J Am Heart Assoc 6(5): pii: e005648. May 2017.

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Last updated: 08/26/2020
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