Robert J. Levy, MD

faculty photo
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
Abramson Pediatric Research Center - 702D
3615 Civic Center Blvd
Philadelphia, PA 19104-4318
Office: 215-590-6119
Fax: 215-590-5454
Education:
M.D.
Johns Hopkins University School of Medicine, 1970.
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Description of Research Expertise

Research Summary
Heart Valve Disease: Research programs underway concerning the developmental basis for aortic valve disease, mechanistic studies of progression of calcific aortic stenosis, serotonin mechanisms in heart valve disease, and novel biomaterials for heart valve prostheses.

Gene delivery stents are an area of major interest: plasmid or viral vectors configured in sustained release preparations onto vascular stents for site specific vascular gene therapy.

Magnetic delivery of nanoparticles for pharmaceutical and cell therapy to treat arterial disease.

Selected Publications

Marro M, Kossar AP, Xue Y, Frasca A, Levy RJ, Ferrari G.: Noncalcific Mechanisms of Bioprosthetic Structural Valve Degeneration. J Am Heart Assoc 10(3): e018921, Feb 2 2021

Rock CA, Keeney S, Zakharchenko A, Takano H, Spiegel DA, Krieger AM, Ferrari G, Levy RJ.: Model studies of advanced glycation end product modification of heterograft biomaterials: The effects of in vitro glucose, glyoxal, and serum albumin on collagen structure and mechanical properties. Acta Biomater S1742-7061(21): 00014-3, Jan 2021 Notes: 10.1016/j.actbio.2020.12.053.

Castillero E, Howsmon DP, Rego BV, Keeney S, Driesbaugh KH, Kawashima T, Xue Y, Camillo C, George I, Gorman RC, Gorman JH 3rd, Sacks MS, Levy RJ, Ferrari G.: Altered Responsiveness to TGFβ and BMP and Increased CD45+ Cell Presence in Mitral Valves Are Unique Features of Ischemic Mitral Regurgitation. Arterioscler Thromb Vasc Biol 41(6): 2049-2062, Jun 2021 Notes: doi: 10.1161/ATVBAHA.121.316111.

Frasca A, Xue Y, Kossar AP, Keeney S, Rock C, Zakharchenko A, Streeter M, Gorman RC, Grau JB, George I, Bavaria JE, Krieger A, Spiegel DA, Levy RJ, Ferrari G: Glycation and serum albumin infiltration contribute to the structural degeneration of bioprosthetic heart valves J Am Coll Cardiol Basic Trans Science 5(8): 755-766. Aug 2020

Inamdar VV, Fitzpatrick EG, Alferiev IS, Levy RJ, Stachelek SJ, Fishbein I.: Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization. J Vis Exp. ((166)), Dec 3 2020.

Battig MR, Alferiev IS, Guerrero DT, Fishbein I, Pressly BB, Levy RJ, Chorny M: Experimental Single-Platform Approach to Enhance Functionalization of Magnetically Targetable Cells. ACS Appl Bio Mater 3(6): 3914-3922, Jun 15 2020 Notes: DOI: 10.1021/acsabm.0c00466.

Kossar AP, Anselmo W, Grau JB, Liu Y, Small A, Carter SL, Salvador L, Zhao L, Cvijic ME, Li Z, Yarde M, Rioux N, Rader DJ, Levy RJ, Ferrari G: Circulating and tissue matricellular RNA and protein expression in calcific aortic valve disease. Physiol Genomics 52(4): 191-199, Apr 2020 Notes: PubMed Central in process.

Inamdar VV, Fitzpatrick E, Alferiev I, Nagaswami C, Spruce LA, Fazelinia H, Bratinov G, Seeholzer SH, Levy RJ, Fishbein I, Stachelek SJ: Stability and bioactivity of pepCD47 attachment on stainless steel surfaces. Acta Biomater 104: 231-240, Mar 2020 Notes: doi: 10.1016/j.actbio.2019.12.039.

Fortier JH, Pizzarotti B, Shaw RE, Levy RJ, Ferrari G, Grau J. : Drug-associated valvular heart diseases and serotonin-related pathways: a meta-analysis. Heart 105(15): 1140-1148, Aug 2019 Notes: doi:10.1136/heartjnl-2018-314403.

Anselmo W, Branchetti E, Grau JB, Li G, Ayoub S, Rioux N, Tovmasyan A, Sacks MS, Batinic-Haberle I, Levy RJ, Ferrari G: A Porphyrin-based SOD mimic, Mntnbuoe-2-pyp5+ inhibits mechanisms of aortic valve remodeling in human and murine models of aortic valve sclerosis. J Am Heart Assoc 7(20): e007861, Oct 16 2018.

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Last updated: 07/27/2021
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