Robert J. Levy, MD

faculty photo
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
Abramson Pediatric Research Center - 702D
3615 Civic Center Blvd
Philadelphia, PA 19104-4318
Office: 215-590-6119
Fax: 215-590-5454
Education:
M.D.
Johns Hopkins University School of Medicine, 1970.
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Description of Research Expertise

Research Summary
Heart Valve Disease: Research programs underway concerning the developmental basis for aortic valve disease, mechanistic studies of progression of calcific aortic stenosis, serotonin mechanisms in heart valve disease, and novel biomaterials for heart valve prostheses.

Gene delivery stents are an area of major interest: plasmid or viral vectors configured in sustained release preparations onto vascular stents for site specific vascular gene therapy.

Magnetic delivery of nanoparticles for pharmaceutical and cell therapy to treat arterial disease.

Selected Publications

Hooshdaran B, Pressly BB, Alferiev IS, Smith JD, Zoltick PW, Tschabrunn CM, Wilensky RL, Gorman RC, Levy RJ, Fishbein I : Stent-Based Delivery of AAV2 Vectors Encoding Oxidation-Resistant apoA1 Sci. Rep. 12(1): 5464, Mar 2022.

Zakharchenko A, Xue Y, Keeney S, Rock C, Alferiev I, Stachelek S, Takano H, Thomas T, Nagaswami C, Krieger AM, Chorny M, Ferrari G, Levy RJ.: Poly-2-methyl-2-oxazoline modified bioprosthetic heart valve leaflets have enhanced biocompatibility and resist structural degeneration. Proc Natl Acad Sci USA. 119(6): e2120694119, Feb 2022.

Xue Y, Kossar AP, Abramov A, Frasca A, Sun M, Zyablitskaya M, Paik D, Kalfa D, Della Barbera M, Thiene G, Kozaki S, Kawashima T, Gorman JH, Gorman RC, Gillespie MJ, Carreon CK, Sanders SP, Levy RJ, Ferrari G.: Age-related enhanced degeneration of bioprosthetic valves due to leaflet calcification, tissue crosslinking, and structural changes. Cardiovasc Res Page: cvac002, Jan 10 2022 Notes: PMC in process. doi: 10.1093/cvr/cvac002.

Alferiev IS, Fishbein I, Levy RJ, Chorny M : Robust Chemical Strategy for Stably Labeling Polyester-Based Nanoparticles with BODIPY Fluorophores. ACS Appl. Polym. Mater. 4(2): 1196–1206, 2022 Notes: NIHMS1780787.

Marro M, Kossar AP, Xue Y, Frasca A, Levy RJ, Ferrari G.: Noncalcific Mechanisms of Bioprosthetic Structural Valve Degeneration. J Am Heart Assoc 10(3): e018921, Feb 2 2021

Rock CA, Keeney S, Zakharchenko A, Takano H, Spiegel DA, Krieger AM, Ferrari G, Levy RJ.: Model studies of advanced glycation end product modification of heterograft biomaterials: The effects of in vitro glucose, glyoxal, and serum albumin on collagen structure and mechanical properties. Acta Biomater S1742-7061(21): 00014-3, Jan 2021 Notes: 10.1016/j.actbio.2020.12.053.

Castillero E, Howsmon DP, Rego BV, Keeney S, Driesbaugh KH, Kawashima T, Xue Y, Camillo C, George I, Gorman RC, Gorman JH 3rd, Sacks MS, Levy RJ, Ferrari G.: Altered Responsiveness to TGFβ and BMP and Increased CD45+ Cell Presence in Mitral Valves Are Unique Features of Ischemic Mitral Regurgitation. Arterioscler Thromb Vasc Biol 41(6): 2049-2062, Jun 2021 Notes: doi: 10.1161/ATVBAHA.121.316111.

Pressly BB, Hooshdaran B, Alferiev IS, Chorny M, Levy RJ, Fishbein I: Adeno-Associated Viral Vector Immobilization and Local Delivery from Bare Metal Surfaces. Methods in Molecular Biology in: Biomedical Engineering Technologies: Vol 2. A Rasooly, H Baker, MR Ossandon (eds.). Springer Nature, 2394 , 2021 Notes: doi.org/10.1007/978-1-0716-1811-0_32. in press.

Frasca A, Xue Y, Kossar AP, Keeney S, Rock C, Zakharchenko A, Streeter M, Gorman RC, Grau JB, George I, Bavaria JE, Krieger A, Spiegel DA, Levy RJ, Ferrari G: Glycation and serum albumin infiltration contribute to the structural degeneration of bioprosthetic heart valves J Am Coll Cardiol Basic Trans Science 5(8): 755-766. Aug 2020

Inamdar VV, Fitzpatrick EG, Alferiev IS, Levy RJ, Stachelek SJ, Fishbein I.: Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization. J Vis Exp. ((166)), Dec 3 2020.

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Last updated: 05/04/2022
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