Jason M Brenchley, Ph.D.

faculty photo
Adjunct Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
4 Center Dr. Rm 201
Immunopathogenesis Section
Lab of Molecular Microbiology
Bethesda, MD 20892
Office: 301-496-1498
Education:
BS (Microbiology)
Idaho State University, 1998.
BS (Chemistry)
Idaho State University, 1998.
MS (Chemistry)
Idaho State University, 1999.
PhD (Immunology)
University of Texas Southwestern Medical Center at Dallas, 2003.
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Selected Publications

Petrovas Constantinos, Yamamoto Takuya, Price David A, Rao Srinivas S, Klatt Nichole R, Brenchley Jason M, Douek Daniel C, Gostick Emma, Angermann Bastian R, Grossman Zvi, Macallan Derek C, Meier-Schellersheim Martin, Koup Richard A: High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance. Journal of virology 87(17): 9836-44, Sep 2013.

Brenchley J M: Mucosal immunity in human and simian immunodeficiency lentivirus infections. Mucosal immunology 6(4): 657-65, Jul 2013.

Grainger John R, Wohlfert Elizabeth A, Fuss Ivan J, Bouladoux Nicolas, Askenase Michael H, Legrand Fanny, Koo Lily Y, Brenchley Jason M, Fraser Iain D C, Belkaid Yasmine: Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection. Nature medicine 19(6): 713-21, Jun 2013.

Tabb Brian, Morcock David R, Trubey Charles M, QuiƱones Octavio A, Hao Xing Pei, Smedley Jeremy, Macallister Rhonda, Piatak Michael, Harris Levelle D, Paiardini Mirko, Silvestri Guido, Brenchley Jason M, Alvord W Gregory, Lifson Jeffrey D, Estes Jacob D: Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection. The Journal of infectious diseases 207(6): 880-92, Mar 2013.

Canary Lauren A, Vinton Carol L, Morcock David R, Pierce Jordan B, Estes Jacob D, Brenchley Jason M, Klatt Nichole R: Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. Journal of immunology (Baltimore, Md. : 1950) 190(6): 2959-65, Mar 2013.

Lugli Enrico, Dominguez Maria H, Gattinoni Luca, Chattopadhyay Pratip K, Bolton Diane L, Song Kaimei, Klatt Nichole R, Brenchley Jason M, Vaccari Monica, Gostick Emma, Price David A, Waldmann Thomas A, Restifo Nicholas P, Franchini Genoveffa, Roederer Mario: Superior T memory stem cell persistence supports long-lived T cell memory. The Journal of clinical investigation 123(2): 594-9, Feb 2013.

Klatt Nichole R, Canary Lauren A, Sun Xiaoyong, Vinton Carol L, Funderburg Nicholas T, Morcock David R, QuiƱones Mariam, Deming Clayton B, Perkins Molly, Hazuda Daria J, Miller Michael D, Lederman Michael M, Segre Julie A, Lifson Jeffrey D, Haddad Elias K, Estes Jacob D, Brenchley Jason M: Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. The Journal of clinical investigation 123(2): 903-7, Feb 2013.

Klatt Nichole R, Funderburg Nicholas T, Brenchley Jason M: Microbial translocation, immune activation, and HIV disease. Trends in microbiology 21(1): 6-13, Jan 2013.

Dang Que, Whitted Sonya, Goeken Robert M, Brenchley Jason M, Matsuda Kenta, Brown Charles R, Lafont Bernard A P, Starost Matthew F, Iyengar Ranjini, Plishka Ronald J, Buckler-White Alicia, Hirsch Vanessa M: Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques. Journal of virology 86(24): 13795-9, Dec 2012.

Brenchley Jason M, Vinton Carol, Tabb Brian, Hao Xing Pei, Connick Elizabeth, Paiardini Mirko, Lifson Jeffrey D, Silvestri Guido, Estes Jacob D: Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections. Blood 120(20): 4172-81, Nov 2012.

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Last updated: 11/18/2013
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