Jorge Henao-Mejia, M.D., Ph.D.

faculty photo
Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
The University of Pennsylvania
The Institute for Immunology
Biomedical Research Building II/III, Room 321
Philadelphia, PA 19104
Lab: 215-898-2212
M.D. (Medicine)
University of Antioquia, Colombia, 2005.
Ph.D. (Microbiology and Immunology)
Indiana University, 2009.
Permanent link

Selected Publications

Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, Müller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC: Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. Procedures of the National Academy of Sciences of the United States of America 112(10): 3056-61, March 2015.

Adam Williams*, Jorge Henao-Mejia*, Richard A. Flavell* * Corrsponding authors and equal contribution: The generation of genetically modified mice using the CRISPR/Cas9 genome editing system Cold Spring Harbor Protocols Page: In press, 2015.

Jorge Henao-Mejia1*, Adam Williams*, Anthony Rongvaux, Judith Stein, Cynthia Hughes, Richard A. Flavell* *Corresponding authors and equal contribution: Protocol for the generation of genetically modified mice using the CRISPR/Cas9 genome editing system Cold Spring Harbor Protocols Page: In Press, 2015.

Wlodarska M., R. Nowarski, C.A. Thaiss, J. Henao-Mejia, J.P. Zhang, G. Frankel, L. Hao, W.M. Philbrick, E. Elinav, B.B. Finlay, R.A. Flavell: NLRP6 inflammasome regulates the intestinal host-microbial interface by orchestrating globlet cell-mediated mucus secretion. Cell 156(5): 1045-1059, 2014.

Henao-Mejia J.*, E. Elinav*, C.A. Thaiss*, R.A. Flavell: Inflammasomes and metabolic disease. Annu Rev Physiol 2014.

Hacisuleyman E., L.A. Goff, C. Trapnell, M. Sauvageau, D.G. Hendrickson, D.R Kelley, P. McClanahan, A. Williams, J. Henao-Mejia, L. Sun, J. Engreitz, M. Guttman, E.S. Lander, R.A. Flavell, H.F. Lodish, A. Raj, J.L. Rinn: Trans-chromosomal and nuclear matrix interactions require a lincRNA that escapes X chromosome inactivation. Nat Struct Mol Biol. 21: 198-206, 2014.

Henao-Mejia, J.*, T. Strowig* and R. Flavell: Microbiota keeps the intestinal clock ticking. Cell 153: 741-743 2013.

Henao-Mejia J.*, A. Williams*, L.A. Goff, M. Staron, P. Licona-Limón, S.M. Kaech, M. Nakayama, J.L. Rinn, R.A. Flavell: The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis Immunity 38: 1-14, 2013 Notes: *These authors contributed equally to this work.

Henao-Mejia, J.*, E. Elinav*, C.A Thaiss, Paula Licona-Limon, R.A. Flavell: Role of the intestinal microbiome in liver disease. J Autoimmun 46: 66-73, 2013.

Henao-Mejia, J.*, E. Elinav* and R.A. Flavell: Integrative inflammasome activity in the regulation of intestinal mucosal immune responses. Mucosal Immunology 6: 4-13, 2013.

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Last updated: 03/30/2015
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