Brian D. Keith

faculty photo
Adjunct Professor of Cancer Biology
Department: Cancer Biology
Graduate Group Affiliations

Contact information
Abramson Family Cancer Research Institute
University of Pennsylvania
421 Curie Blvd.
Philadelphia, PA 19104
Office: 215 746-5533
Fax: 215 746-5511
Sc B (Biology)
Brown University, 1980.
Ph.D. (Plant Molecular Biology)
The Rockefeller University, 1987.
Permanent link

Description of Research Expertise

Research Interests
How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.

Key words: mouse, development, transcription, hypoxia, cancer.

Description of Research
As part of a long-standing collaboration with Dr. Celeste Simon, I generate mouse models in which genes encoding critical components of the hypoxic response pathway are mutated. These tools offer insights into physiological responses to hypoxia during normal development, as well as in pathological contexts (ischemia, cancer).

Rotation Projects
Students intersted in rotation projects should refer to Dr. Celeste Simon's lab page.

Lab personnel:
Please refer to Dr. Celeste Simon's lab

Selected Publications

Skuli N, Liu L, Wang T, Patel S, Runge A, Iruela-Arispe L, Simon MC, and Keith B.: Endothelial deletion of Hypoxia Inducible Factor-2alpha (HIF-2α) alters vascular function and tumor angiogenesis. Blood 114(2): 469-77, 2009.

Mastrogiannaki M, Matak P, Keith B, Simon MC, Vaulont S, Peyssonnaux C.: HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J Clin Invest 2009.

Gordan JD, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, Greenberg RA, Flaherty KT, Rathmell WK, Keith B, Simon MC, Nathanson KL.: HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 14(6): 435-46, 2008.

Rankin EB, Rha J, Unger TL, Wu CH, Shutt, HP, Johnson RS, Simon MC, Keith B, Haase VH.: Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene 27(40): 5354-8, 2008.

Simon MC, Keith, B.: The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol 9(4): 285-96, 2008.

Keith B, Simon MC.: Hypoxia-inducible factors, stem cells, and cancer. Cell 129(3): 465-72, 2007.

Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC.: Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A 104(7): 2301-6, 2007.

Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B.: HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev 20(5): 557-70, 2006.

Liu L, Cash TP, Jones RG, Keith B, Thompson CB, and Simon MC.: Hypoxia induced energy stress regulates mRNA translation and cell growth. Molecular Cell 21: 521-531, 2006.

Covello KL, Simon MC, and Keith B.: Targeted replacement of HIF-1α by a HIF-2α knock-in allele promotes tumor growth. Cancer Research 65: 2277-2286, 2005.

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Last updated: 10/25/2013
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