Stewart A Anderson

faculty photo
Associate Professor of Psychiatry
Department: Psychiatry
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Abramson Research Center
Room 517
Philadelphia, PA 19147
BA (Neuroscience )
Amherst College, 1984.
MD (Medicine)
University of Connecticut, 1989.
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Description of Research Expertise

The focus of my laboratory concerns the molecular and cellular mechanisms that govern the development of the mammalian forebrain. We use mouse genetics, forebrain slice and dissociated culture techniques, as well as mouse and human pluripotent stem cells in cell culture and transplantation experiments to study the fate determination of interneurons of the cerebral cortex. We are particularly interested in understanding the molecular underpinnings behind the fate determination and axon targeting of subclasses of GABAergic interneurons implicated in the neuropathology of schizophrenia. In addition, we are exploring the use of mouse and human stem cell-derived interneurons in cell-based therapies for seizures, and as tools for the study of gene-gene and gene-environment interactions in neuropsychiatric disease, including schizophrenia and autism.

Selected Publications

Gilani AI, Inan M, Chohan MO; Schobel SA, Chaudhury NH, Chuhma N, Glickstein S, MerkerR, Steinfeld S, Xu Q, Small SA, Anderson SA*, Ross ME*, Moore H*. *corresponding authors. : Interneuron precursor transplants into adult hippocampus reverse psychosis-relevant features in a mouse hippocampal disinhibition model PNAS 111(20): 7450-7455. 2014.

Tyson JA, Anderson SA.: GABAergic Interneuron Transplants to Study Development and Treat Disease. Trends in Neurosciences 73 (3): 169-177, 2014.

Inan, M., Petros, T. J., Anderson, S. A.: Losing your inhibition: linking cortical GABAergic interneurons to schizophrenia. Neurobiol Dis 53: 36-48, 2013.

Petros, T. J., Maurer, C. W., Anderson, S. A.: Enhanced derivation of mouse ESC-derived cortical interneurons by expression of Nkx2.1. Stem Cell Res 11(1): 647-56, 2013.

Maroof, A. M., Keros, S., Tyson, J. A., Ying, S. W., Ganat, Y. M., Merkle, F. T., Liu, B., Goulburn, A., Stanley, E. G., Elefanty, A. G., Widmer, H. R., Eggan, K., Goldstein, P. A., Anderson, S. A., Studer, L.: Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell 12(5): 559-72, 2013.

Goulburn, A. L., Stanley, E. G., Elefanty, A. G., Anderson, S. A.: Generating GABAergic cerebral cortical interneurons from mouse and human embryonic stem cells. Stem Cell Res 8(3): 416-26, 2012.

Inan, M., Welagen, J., Anderson, S. A.: Spatial and temporal bias in the mitotic origins of somatostatin- and parvalbumin-expressing interneuron subgroups and the chandelier subtype in the medial ganglionic eminence. Cereb Cortex 22(4): 820-7, 2012.

Brown, K. N., Chen, S., Han, Z., Lu, C. H., Tan, X., Zhang, X. J., Ding, L., Lopez-Cruz, A., Saur, D., Anderson, S. A., Huang, K., Shi, S. H.: Clonal production and organization of inhibitory interneurons in the neocortex. Science 334(6055): 480-6, 2011.

De la Cruz, E., Zhao, M., Guo, L., Ma, H., Anderson, S. A., Schwartz, T. H.: Interneuron Progenitors Attenuate the Power of Acute Focal Ictal Discharges. Neurotherapeutics 2011.

Cundiff, P. E., Anderson, S. A.: Impact of induced pluripotent stem cells on the study of central nervous system disease. Curr Opin Genet Dev 21(3): 354-61, 2011.

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Last updated: 07/18/2014
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