Faculty

Stewart A Anderson, MD

Professor of Psychiatry

Department: Psychiatry

Graduate Group Affiliations

Contact information

3615 Civic Center Blvd.
Abramson Research Center
Room 517
Philadelphia, PA 19147

Office: 215-590-6527
Fax: 215-590-3709

Email:
andersons3@email.chop.edu

Education:
BA (Neuroscience and Psychology)
Amherst College, Amherst, MA, 1984.
MD (Medicine)
University of Connecticut, Storrs, CT, 1989.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

I am a psychiatrist who worked mainly with treatment-resistant outpatients suffering from schizophrenia. Since moving in July, 2012 from Cornell Medical College to UPenn/The Children's Hospital of Philadelphia, I am not seeing patients as I focus on laboratory research into the causes of neuropsychiatric illnesses.

Description of Research Expertise

I am a Children's Hospital of Philadelphia-based faculty in the Department of Psychiatry at UPenn.
The focus of my laboratory concerns the molecular and cellular mechanisms that govern the development of the mammalian forebrain. We use mouse genetics, forebrain slice and dissociated culture techniques, as well as mouse and human pluripotent stem cells in cell culture and transplantation experiments to study the fate determination of interneurons of the cerebral cortex. We are particularly interested in understanding the molecular underpinnings behind the fate determination of subclasses of GABAergic interneurons implicated in the neuropathology of autism and schizophrenia. In addition, we are using mouse and human stem cell-derived interneurons in animal models of cell-based therapies for seizures, psychosis, and as tools for the study of gene-gene and gene-environment interactions in neuropsychiatric disease. Additional projects include the study of mitochondria in stem cell derived neurons derived from people with the 22q11.2 deletion syndrome and schizophrenia, and the study of human stem cell derived microglia infected with HIV.
For more information, please visit the Anderson lab website at:
https://stewandersonlab.research.chop.edu/

Selected Publications

Crockett, A. M., Kebir, H., Anderson, S. A., Jyonouchi, S., Romberg, N., Alvarez, J. I.: 22q11.2 Deletion-Associated Blood-Brain Barrier Permeability Potentiates Systemic Capillary Leak Syndrome Neurologic Features. J Clin Immunol 44(4): 87, 2024.

Littleton, S. H., Trang, K. B., Volpe, C. M., Cook, K., DeBruyne, N., Maguire, J. A., Weidekamp, M. A., Hodge, K. M., Boehm, K., Lu, S., Chesi, A., Bradfield, J. P., Pippin, J. A., Anderson, S. A., Wells, A. D., Pahl, M. C., Grant, S. F. A.: Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3'' UTR of FAIM2. Cell Genom 4(5): 100556, 2024.

Iascone, D. M., Zhang, X., Brafford, P., Mesaros, C., Sela, Y., Hofbauer, S., Zhang, S. L., Madhwal, S., Cook, K., Pivarshev, P., Stanger, B. Z., Anderson, S., Dang, C. V., Sehgal, A.: Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells. Proc Natl Acad Sci U S A 121(30): e2319782121, 2024.

Qu, G., Merchant, J. P., Clatot, J., DeFlitch, L. M., Frederick, D. J., Tang, S., Salvatore, M., Zhang, X., Li, J., Anderson, S. A., Goldberg, E. M.: Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy. Brain 147(4): 1247-1263, 2024.

Crockett AM, Kebir. H, Benallegue, Adelman P, Gur RE, Sullivan S, Anderson SA, Alvarez JI : Immune status of the murine 22q11.2 deletion syndrome model European Journal of Immunology 53(1): https://doi.org/10.1002/eji.202249840, January 2023.

Lu, Y., Lee, J., Li, J., Allu, S. R., Wang, J., Kim, H., Bullaughey, K. L., Fisher, S. A., Nordgren, C. E., Rosario, J. G., Anderson, S. A., Ulyanova, A. V., Brem, S., Chen, H. I., Wolf, J. A., Grady, M. S., Vinogradov, S. A., Kim, J., Eberwine, J.: CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential. Nat Commun 14(1): 7346, 2023.

Cristancho AG, Gadra EC, Samba IM, Zhao C, Ouyang M, Magnitsky S, Huang H, Viaene AN, Anderson SA, Marsh ED.: Deficits in seizure threshold and other behaviors in adult mice without gross neuroanatomic injury after late gestation transient prenatal hypoxia. Dev Neurosci Mar 2022.

Cook K, Anderson SA: Genesis and migration of cerebral cortical inhibitory interneurons: an overview. Chapter 186 in; Chapter 186 in Neuroscience in the 21st Century. D. Pfaff (eds.). Springer Nature, in press 2022.

Singh LN, Ennis B, Loneragan B, Tsao NL, Lopez Sanchez MIG, Li J, Acheampong P, Tran O, Trounce IA, Zhu Y, Potluri P; Regeneron Genetics Center, Emanuel BS, Rader DJ, Arany Z, Damrauer SM, Resnick AC, Anderson SA, Wallace DC.: MitoScape: A big-data, machine-learning platform for obtaining mitochondrial DNA from next-generation sequencing data. PLoS Comput Biol 17: e1009594, Nov 2021.

Li J, Tran OT, Crowley TB, Moore TM, Zackai EH, Emanuel BS, McDonald-McGinn DM, Gur RE, Wallace DC, Anderson SA.: Association of Mitochondrial Biogenesis With Variable Penetrance of Schizophrenia. JAMA Psychiatry 78: 911-921, Aug 2021.