David M. Feldser, Ph.D.

faculty photo
Assistant Professor of Cancer Biology
Department: Cancer Biology
Graduate Group Affiliations

Contact information
421 Curie Blvd.
Philadelphia, PA 19104-6160
Office: 215-898-9203
Fax: 215-573-6735
Lab: 215-746-1452
B.S. (Biochemistry and Molecular Biology)
Juniata College, 1998.
Ph.D. (Human Genetics and Molecular Biology)
Johns Hopkins University School of Medicine, 2007.
Permanent link

Description of Research Expertise

Research Interests
- Mechanisms of tumor-suppressor gene action
- Role of the immune system in tumor suppression
- Genome engineering in the mouse
- Chemical genetic strategies to modulate tumor suppression

Key Words: mouse modeling, tumor suppressors, tumor immunology, tumor microenvironment, lung cancer

Current Research In The Feldser Laboratory
The Feldser lab uses genetically engineered mouse models to study tumor progression and metastasis of common forms of human cancer. These models faithfully recapitulate many aspects of the histopathological progression of their human counterparts. Tumors initiate as lesions within the appropriate tissue microenvironment from single cells due to induced activation of latent oncogenes and/or deletion of key tumor suppressor genes. These lesions evolve through multiple cellular states toward malignant and metastatic disease. Our research is dedicated to deconstructing the multistep process of tumorigenesis. The major emphasis of our laboratory is to uncover the pathways that are disabled by mutational inactivation of tumor-suppressor genes as well as those pathways stimulated by aberrant oncogene activation. We focus on mouse models in order to employ novel genetic tools to regulate gene function in developing cancerous lesions as well as to track cancer growth and dissemination via bioluminescent and fluorescent techniques. We couple cellular, genomic and biochemical analyses to our powerful in vivo tools to discern the mechanics of tumor progression and metastasis with the goal of identifying new therapeutic strategies to eradicate malignant cells.

Rotation Projects
- Studies of the physiological role of p53, Rb, and Kras in lung cancer
- Oncogene signal amplification in tumor initiation and progression
- Validation of novel methods to regulate gene function in the mouse
- Characterization of chemical regulators of tumor suppressors

Please contact Dr. Feldser to discuss specific rotation projects.

Selected Publications

Chiou SH, Kim-Kiselak C, Risca V, Heimann M, Chuang CH, Burds A, Greenleaf W, Jacks T, Feldser DM, Winslow MM: A conditional system to specifically link disruption of protein-coding function with reporter expression in mice. Cell Reports 7(6): 2078-86, 2014.

Feldser D M: The p53 Tumor Suppressor Activates a Tumor Immune Surveillance Pathway That Requires Natural Killers Cells. Salk Institute: Mechanisms and Models of Cancer 2013.

Feldser D M: The p53 tumor suppressor orchestrates a novel tumor immune surveillance pathway that requires natural killer cells. Cold Spring Harbor: Mechanisms and Models of Cancer 2012.

Xue W, Meylan E, Oliver T G, Feldser D M, Winslow M M, Bronson R, Jacks T: Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma. Cancer Discovery 1(3): 236-47, Aug 2011.

Winslow M M, Dayton T L, Verhaak R G W, Kim-Kiselak C, Snyder E L, Feldser D M, Hubbard D D, DuPage M J, Whittaker C A, Hoersch S, Yoon S, Crowley D, Bronson R T, Chiang D Y, Meyerson M, Jacks T: Suppression of lung adenocarcinoma progression by Nkx2-1. Nature 473(7345): 101-4, May 2011.

Feldser D M: Uncovering p53 Tumor-Suppressor Mechanisms in Lung Adenocarcinoma. Salk Institute: Mechanisms and Models of Cancer 2011.

Feldser D M, Kostova K K, Winslow M M, Taylor S E, Cashman C, Whittaker C A, Sanchez-Rivera F J, Resnick R, Bronson R, Hemann M T, Jacks T: Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature 468(7323): 572-5, Nov 2010.

Huarte M, Guttman M, Feldser D, Garber M, Koziol M J, Kenzelmann-Broz D, Khalil A M, Zuk O, Amit I, Rabani M, Attardi L D, Regev A, Lander E S, Jacks T, Rinn J L: A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142(3): 409-19, Aug 2010.

Feldser D M: Experimental restoration of tumor suppressor function identifies a context specific sensitivity to p53 in non-small cell lung cancer. Cold Spring Harbor: Mechanisms and Models of Cancer 2010.

Meylan E, Dooley A L, Feldser D M, Shen L, Turk E, Ouyang C, Jacks T: Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature 462(7269): 104-7, Nov 2009.

back to top
Last updated: 07/29/2014
The Trustees of the University of Pennsylvania