Benjamin L. Prosser, Ph.D

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Assistant Professor of Physiology
Department: Physiology

Contact information
Clinical Research Building Rm 726
415 Curie Blvd.
Philadelphia, PA 19104
Office: 215-746-1488
BS (Health and Exercise Science)
Wake Forest University, 2005.
Ph.D (Molecular Medicine)
University of Maryland School of Medicine, 2009.
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Description of Research Expertise

cardiac electrophysiology
excitation-contraction coupling
calcium signaling
redox signaling

Selected Publications

Hu Li-Yen R, Ackermann Maegen A, Hecker Peter A, Prosser Benjamin L, King Brendan, O'Connell Kelly A, Grogan Alyssa, Meyer Logan C, Berndsen Christopher E, Wright Nathan T, Jonathan Lederer W, Kontrogianni-Konstantopoulos Aikaterini: Deregulated Ca(2+) cycling underlies the development of arrhythmia and heart disease due to mutant obscurin. Science advances 3(6): e1603081, Jun 2017.

Robison P, Prosser BL: Microtubule mechanics in the working myocyte. Journal of Physiology Epub, Jan 2017.

Chiou Kevin K, Rocks Jason W, Chen Christina Yingxian, Cho Sangkyun, Merkus Koen E, Rajaratnam Anjali, Robison Patrick, Tewari Manorama, Vogel Kenneth, Majkut Stephanie F, Prosser Benjamin L, Discher Dennis E, Liu Andrea J: Mechanical signaling coordinates the embryonic heartbeat. Proceedings of the National Academy of Sciences of the United States of America 113(32): 8939-44, Aug 2016.

Robison Patrick, Caporizzo Matthew A, Ahmadzadeh Hossein, Bogush Alexey I, Chen Christina Yingxian, Margulies Kenneth B, Shenoy Vivek B, Prosser Benjamin L: Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes. Science (New York, N.Y.) 352(6284): aaf0659, Apr 2016.

Saritu Limbu, Tuan M Honag-Trong, Benjamin L Prosser, W Jonathan Lederer, and M Saleet Jafri: Modeling Local X-ROS and Calcium Signaling in the Heart. Biophysical Journal 109(10): 2037-2050, November 2015.

Jaclyn P. Kerr, Patrick Robison, Guoli Shi, Alexey I. Bogush, Stuart S. Martin, Roberto Ratieri, Benjamin L. Prosser, Christopher W. Ward: Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle Nature Communications 10.1038/NCOMMS9526, October 2015 Notes: Prosser is co-senior/corresponding author.

Zhang Min, Prosser Benjamin L, Bamboye Moradeke A, Gondim Antonio N S, Santos Celio X, Martin Daniel, Ghigo Alessandra, Perino Alessia, Brewer Alison C, Ward Christopher W, Hirsch Emilio, Lederer W Jonathan, Shah Ajay M: Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation. Journal of the American College of Cardiology 66(3): 261-72, Jul 2015 Notes: M.Z. and B.L.P. contributed equally to this manuscript.

Michael J. Previs, Benjamin L Prosser, Ji Young Mun, W.J. Lederer, David M. Warshaw: Myosin-Binding Protein C corrects an intrinsic non-uniformity in cardiac excitation-contraction coupling. Biophysical Society 59th Annual Meeting February 2015.

Patrick G. Robison, Jaclyn P Kerr, Alexey I Bogush, Daniel A Harki, Christopher W. Ward, Benjamin L. Prosser: Microtubule detyrosination modulates stretch-dependent X-ROS signaling in heart. Biophysical Society 59th Annual Meeting February 2015.

Michael J. Previs*, Benjamin L. Prosser*, Ji Young Mun*, Samantha Beck Previs, James Gulick, Kyounghwan Lee, Jeffrey Robbins, Roger Craig, W.J. Lederer, David M. Warshaw: Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling. Science Advances 1(1), February 2015 Notes: *these authors contributed equally to this manuscript.

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Last updated: 04/20/2018
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