Faculty

Benjamin L. Prosser, Ph.D

Associate Professor of Physiology

Department: Physiology

Graduate Group Affiliations

Contact information

Clinical Research Building Rm 779
415 Curie Blvd.
Philadelphia, PA 19104

Office: 215-746-1488

Email:
bpros@mail.med.upenn.edu

Publications

Search PubMed for articles

Education:
BS (Health and Exercise Science)
Wake Forest University, 2005.
Ph.D (Molecular Medicine)
University of Maryland School of Medicine, 2009.

Links
Search PubMed for articles
Prosser lab website
Center for Epilepsy and NeuroDevelopmental Disorders

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

physiology
muscle biology
neurodevelopmental disorders
antisense oligonucleotides
heart failure
cytoskeleton
microtubules
RNA biology

Selected Publications

Pavlov DA, Heffler J, Suay-Corredera C, Dehghany M, Shen KM, Zuela-Sopilniak N, Randell R, Uchida K, Jain R, Shenoy V, Lammerding J, Prosser B.: Microtubule forces drive nuclear damage in LMNA cardiomyopathy. Nat Cardiovasc Res Oct 2025 Notes: Full citation info not yet available. Epub 10 October 2025 https://doi.org/10.1038/s44161-025-00727-w.

(Amida Pavlov D, Proser BL) Research briefing with no author in official Nat Cardiovascular Res citation: A microtubule cage damages weakened nuclei in a genetic cardiomyopathy. Nat Cardiovasc Res. Oct 2025.

El Khatib M, Fye MA, Uchida K, Obaid AL, Troxler T, Valente D, Salzberg BM, Prosser B, Kaverina IN, Vinogradov SA.: Water-Soluble Molecular Wires for Membrane Potential Imaging. Angew Chem Int Ed Engl. 64(37), Sep 2025.

Latchman NR, Stevens TL, Bedi KC, Prosser BL, Margulies KB, Elrod JW.: Ultrastructure analysis of mitochondria, lipid droplet and sarcoplasmic reticulum apposition in human heart failure. J Mol Cell Cardiol Plus. 13, Jun 2025.

Erlich I, Douvdevany G, Haddad R, Prosser BL, Kehat I. : Single molecule imaging reveals extracellular signal-regulated kinases dependent signal responsive spatial regulation of translation in cardiomyocytes. bioRxiv May 2025.

Harrison AG, Magielski JH, McSalley I, Ganesan S, Prentice AJ, Cunningham KG, Pierce SR, Boland MJ, Prosser BL, Helbig I, McKee JL.: Familial SYNGAP1 variants define the boundaries of a complex neurodevelopmental disorder with epilepsy. Epilepsia 66(9): 3505-3515, May 2025.

McKee JL, Magielski JH, Xian J, Cohen S, Toib J, Harrison A, Chen C, Kim D, Rathod A, Brimble E, Fitter N, Graglia JM, Helde KA, McKeown Ruggiero S, Boland MJ, Prosser BL, Sederman R, Helbig I.: Clinical signatures of SYNGAP1-related disorders through data integration. Genet Med.(101419), Mar 2025 Notes: doi: 10.1016/j.gim.2025.101419.

Uchida K, Scarborough EA, Prosser BL: Dual Translational Control in Cardiomyocytes by Heterogeneous mTORC1 and Hypertrophic ERK Activation. bioRxiv Feb 2025.

Hartman H, Uy G, Uchida K, Scarborough EA, Yang Y, Barr E, Williams S, Kavar SL, Brandimarto J, Li L, Lai L, Griffin J, Yucel N, Shewale S, Rajagopal H, Eaton DM, Dorwart T, Bedi KC, Conn CS, Margulies K, Prosser B, Arany Z, Edwards JJ.: ROR2 drives right ventricular heart failure via disruption of proteostasis. bioRxiv Feb 2025.

Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herrera-Rivero M, Siebels B, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo M, Lindner D, Prosser BL, Carrier L.: Chronic Activation of Tubulin Tyrosination Improves Heart Function. Circ Res. 135(9), Sep 2024.