Sergei Vinogradov, PhD
Associate Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics
Graduate Group Affiliations
Contact information
1013B Stellar-Chance Labs
Department of Biochemistry and Biophysics
36th Street and Hamilton Walk
Philadelphia, PA 19104-6059
Department of Biochemistry and Biophysics
36th Street and Hamilton Walk
Philadelphia, PA 19104-6059
Office: 2155737524
Email:
VINOGRAD@MAIL.MED.UPENN.EDU
VINOGRAD@MAIL.MED.UPENN.EDU
Education:
Ph.D. (Organic Chemistry)
Moscow State University, 1995.
Permanent linkPh.D. (Organic Chemistry)
Moscow State University, 1995.
Description of Research Expertise
Dr. Vinogradov's research revolves around functional molecular systems related to biological objects by function or application. We use methods of synthetic organic chemistry to design and construct molecules with predefined degree of active site encapsulation, photophysical properties and tunable energy and electron transfer pathways. Our special area of interest is construction of advanced probes for optical microscopy and imaging. We are developing methods for imaging of oxygen in biological tissues using phosphorescence quenching, including near infrared tomography by phosphorescence lifetime and two-photon microscopy of oxygen. These techniques are expected to provide useful tools for research in cancer, diabetes, ophthalmology and neuroscience. Two areas of chemistry are recurrent in our research: porphyrins and dendrimers. We study photophysics, acid/base properties and electrochemistry of aromatically pi-extended porphyrins, addressing various structure-property relationships in this porphyrin family.Selected Publications
Thyagarajan, S., Leiding, T., Peterson Årsköld, S., Cheprakov, A. V., Vinogradov, S. A.: Highly non-planar dendritic porphyrin for pH sensing: observation of porphyrin monocation. Inorganic Chemistry 49: 9909-9920, 2010.Sakadžić, S., Roussakis, E., Yaseen, M. A., Srinivasan, V. J., Mandeville, E. T., Devor, A., Lo, E. H., Vinogradov, S. A., Boas, D. A.: Two-photon high-resolution imaging of partial pressure of oxygen in cerebral vasculature and tissue. Nature Methods 7: 755-759, 2010.
Louise E. Sinks, Gregory P. Robbins, Emmanuel Roussakis, Thomas Troxler, Daniel A. Hammer, Sergei A. Vinogradov: Two-Photon Microscopy of Oxygen: Polymersomes as Probe Carrier Vehicles. Journal of Physical Chemistry B 114: 14373-14382, 2010.
Filatov, M. A., Lebedev, A. Y., Mukhin, S. N., Vinogradov, S. A., Cheprakov, A. V.: pi-Extended Dipyrrins Capable of Highly Fluorogenic Complexation with Metal Ions. Journal of the American Chemical Society 132(28): 9552-9554, 2010.
Lebedev, A. Y., Cheprakov, A. V., Sakadzic, S., Boas, D. A., Wilson, D. F., Vinogradov, S. A.: Dendritic phosphorescent probes for oxygen imaging in biological systems. Acs Applied Materials & Interfaces 1(6): 1292-1304, 2009.
Yaseen, M. A., Srinivasan, V. J., Sakadzic, S., Wu, W., Ruvinskaya, S., Vinogradov, S. A., Boas, D. A.: Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy. Optics Express 17(25): 22341-22350, 2009.
Finikova, O. S., Lebedev, A. Y., Aprelev, A., Troxler, T., Gao, F., Garnacho, C., Muro, S., Hochstrasser, R. M., Vinogradov, S. A.: Oxygen microscopy by two-photon-excited phosphorescence. Chemphyschem 9(12): 1673-1679, 2008.
Apreleva, S. V., Vinogradov, S. A.: Influence of optical heterogeneities on reconstruction of spatial phosphorescence lifetime distributions. Optics Letters 33(8): 782-784, 2008.
Finikova, O.S., Troxler, T., Senes, A., DeGrado, W.F., Hochstrasser, R.M., Vinogradov, S.A.: Energy and Electron Transfer in Enhanced Two-Photon-Absorbing Systems with Triplet Cores. J. Phys. Chem. A 111(30): 6977-6990, 2007.
Apreleva, S. V., Wilson, D. F., Vinogradov, S. A.: Tomographic imaging of oxygen by phosphorescence lifetime. Applied Optics 45(33): 8547-8559, 2006.