• banner image
  • banner image
  • banner image
  • banner image

Welcome to the Department of Biochemistry and Biophysics

Kristen W. Lynch, PhD
Ronen Marmorstein, PhD
Vice Chair

As one of the first departments of Biochemistry and Biophysics in the nation, we are proud of our strong tradition of combining cutting-edge technology with impactful biology. We continue to leverage this interdisciplinary approach to yield break-through discoveries in biomedicine.

Our faculty of over 30 primary and secondary members cover a broad range of research areas, with particular strengths in structural biology, chemical biology, gene regulation and protein folding. 

We are also the proud home of the Eldridge Reeves Johnson Research Foundation which offers advanced physical instrumentation and instruction to researchers across campus.

We are actively growing, with several recent hires, and our faculty are broadly engaged across campus with many joint appointments in other departments, institutes and centers.

We welcome you to learn more about our department in the following pages or contact us.




Titan Krios...
Installation Phase One










News & Publications

  • Englander and Shorter in PNAS
    March 2019
    Walter Englander and Jim Shorter labs team up to use HX to determine dynamic behavior of Hsp104
  • Marmorstein Lab in JBC
    March 2019
    ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis
  • Garcia Lab in JBC
    March 2019
    SILAC and LCMS/MS reveal that phosphorylation of proteins by the kinases PKC, CDK, and MAPK promote myogenic differentiation
  • Garcia Lab in Epigenetics & Chromatin
    February 2019
    Ben Garcia's lab uses time-resolved Mass Spec to map the network of protein changes during EMT

View more

Seminars & Events

  • Friday Research Discussion | Shorter Lab
    Friday, April 12, 2019 • 3:30 pm | JF Library, 2nd floor Anatomy Chemistry
    Mining disaggregase sequence space for enhanced variants
  • Raiziss Seminar | Stephen, PhD
    Thursday, April 18, 2019 • 12 noon | Austrian Auditorium, CRB
    Dynamics of RNA polymerase II transcription
  • BMB Thesis Defense | Ismail Ahmed
    Monday, April 22, 2019 • 3:00 pm | Lynch Lecture Hall, Chemistry Bldg
    The development of unnatural amino acid-based probes and methods for biological studies
  • BMB Thesis Defense | Enrique Lin Shiao
    Wednesday, April 24, 2019 • 1:00 | Law Auditorium, JMEC
    Establishment and regulation of epithelial enhancers by p63

View more

Faculty Spotlight

Jeremy Wilusz, PhD

The Wilusz lab aims to reveal new insights into how RNAs are generated, regulated, and function. By combining high-throughput approaches with detailed biochemical studies, the laboratory has revealed new mechanisms controlling transcription, pre-mRNA processing, and translation of many protein-coding genes. Ongoing efforts are focused on circular RNAs, which have covalently linked ends, and a novel role for the Integrator complex in transcription termination. Congratulations to two postdoctoral fellows in the Wilusz lab who have successfully obtained NIH Pathway to Independence (K99/R00) Awards in the past year!

View more

© The Trustees of the University of Pennsylvania | Site best viewed in a supported browser. | Site Design: PMACS Web Team.