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Welcome to the Department of Biochemistry and Biophysics

Kristen W. Lynch, PhD
Ronen Marmorstein, PhD
Vice Chair

As one of the first departments of Biochemistry and Biophysics in the nation, we are proud of our strong tradition of combining cutting-edge technology with impactful biology. We continue to leverage this interdisciplinary approach to yield break-through discoveries in biomedicine.

Our faculty of over 30 primary and secondary members cover a broad range of research areas, with particular strengths in structural biology, chemical biology, gene regulation and protein folding. 

We are also the proud home of the Eldridge Reeves Johnson Research Foundation which offers advanced physical instrumentation and instruction to researchers across campus.

We are actively growing, with several recent hires, and our faculty are broadly engaged across campus with many joint appointments in other departments, institutes and centers.

We welcome you to learn more about our department in the following pages or contact us.


We are excited to announce the return of biomolecular NMR to PSOM with our new state-of-the-art nuclear magnetic resonance (NMR) system now up and running! Read more about the equipment and how it's being used here. Thank you to Nik Sgourakis and his team for all their efforts in rebuilding NMR expertise here at Penn and CHOP.







News & Publications

  • Burslem on ACS Chemical Biology Advisory Board
    March 2021
    Congratulations to George Burslem on being named a member of Early Career Advisory Board for the journal ACS Chemical Biology
  • Daldal & Murakami Labs in Nature Communications
    February 2021
    Cryo-EM structures of engineered active bc 1-cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes
  • Sgourakis Lab in Nature Communications
    January 2021
    Backbone-independent NMR resonance assignments of methyl probes in large proteins
  • Sellmyer Lab in ACS Chem Biol
    January 2021
    A Chemical Approach for Programmable Protein Outputs Based on Engineered Cell Interactions

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Seminars & Events

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Faculty Spotlight

Kathy Fange Liu

Kathy F. Liu is an Assistant Professor of Biochemistry and Biophysics at the University of Pennsylvania. The Liu lab is focused on the function of modifications in coding and non-coding RNAs in human diseases. Specifically, they use kinetics, structural biology methods, mass spectrometry, RNA biology techniques, combined with next-generation high-throughput sequencing techniques to investigate the crosstalk of modifications across RNA species in neuronal development. (Recent publication here.) Another research focus of the lab is on sex-specific features in the physiology and pathology in the neuronal system. An area of particular interest is the functions of sex-chromosome encoded RNA binding proteins in regulating protein translation and stress granule formation.


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