Welcome to the Department of Biochemistry and Biophysics
As one of the first departments of Biochemistry and Biophysics in the nation, we are proud of our strong tradition of combining cutting-edge technology with impactful biology. We continue to leverage this interdisciplinary approach to yield break-through discoveries in biomedicine.
Our faculty of over 30 primary and secondary members cover a broad range of research areas, with particular strengths in structural biology, chemical biology, gene regulation and protein folding.
We are also the proud home of the Eldridge Reeves Johnson Research Foundation which offers advanced physical instrumentation and instruction to researchers across campus.
We are actively growing, with several recent hires, and our faculty are broadly engaged across campus with many joint appointments in other departments, institutes and centers.
We welcome you to learn more about our department in the following pages or contact us.
Department of Biochemistry & Biophysics
and Graduate Group in Biochemistry & Molecular Biophysics
Dr. George W. Raiziss 36th ANNUAL RETREAT
December 5 & 6, 2019
Skytop Lodge, Pocono Mountains
News & Publications
- Lynch Lab and Garcia Lab in Genome Research
Deep profiling and custom databases improve detection of protesforms generated by alternative splicing
- Moiseenkova-Bell Lab in eLife
Structure-based characterization of novel TRPV5 inhibitors
- Garcia Lab in Nature
Alcohol metabolism contributes to brain histone acetylation
- Shorter Lab in Molecular Cell
Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations
Seminars & Events
- CBI Fall Symposium
Fri, November 15 • 9:30 - 5:30 | Lynch Auditorium & Nobel Hall
- Raiziss Rounds Seminar | Carl Wu, PhD
Thurs, November 21 • 12 noon | Austrian Auditorium, CRB
Single-molecule dynamics and chromatin accessibility of transcription proteins and epigenetic factors in living cells
- Friday Research Discussion | Lynch Lab
Fri, November 22 • 3:30 pm | JF Library, Anatomy-Chemistry, 2nd floor
Splicing stories: From regulation to mechanism
Vera Moiseenkova-Bell is an Associate Professor with appointments in both the Department of Systems Pharmacology and Translational Therapeutics and the Department of Biochemistry and Biophysics. She is also a Faculty Director for the Electron Microscopy Resource Laboratory and Beckman Center for Cryo-Electron Microscopy.
The Moiseenkova-Bell laboratory is focused on understanding structure and function of Transient Receptor Potential (TRP) channels which have been implicated in a diverse range of cellular processes, including pain sensation, neuronal development, cardiovascular and renal pathophysiology, and cancer. Dr. Moiseenkova-Bell and her team utilize cryo-electron microscopy to determine the structural basis of TRP channel activation, inhibition and desensitization mechanisms. Structural information on TRP channels and their interaction with agonists/antagonists at the molecular level will establish a structural framework to enhance our understanding of their function at the molecular level, whereby improving therapeutic strategies and drug design.
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