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Welcome to the Department of Biochemistry and Biophysics

Kristen W. Lynch, PhD
Ronen Marmorstein, PhD
Vice Chair

As one of the first departments of Biochemistry and Biophysics in the nation, we are proud of our strong tradition of combining cutting-edge technology with impactful biology. We continue to leverage this interdisciplinary approach to yield break-through discoveries in biomedicine.

Our faculty of over 30 primary and secondary members cover a broad range of research areas, with particular strengths in structural biology, chemical biology, gene regulation and protein folding. 

We are also the proud home of the Eldridge Reeves Johnson Research Foundation which offers advanced physical instrumentation and instruction to researchers across campus.

We are actively growing, with several recent hires, and our faculty are broadly engaged across campus with many joint appointments in other departments, institutes and centers.

We welcome you to learn more about our department in the following pages or contact us.









News & Publications

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Seminars & Events

  • Faculty Search Seminar | Shuo Han, PhD
    Tues, December 7, 2021 • 2:00pm | BRB Gaulton Auditorium
    A metabolomics pipeline for the mechanistic interrogation of the gut microbiome
  • Raiziss Rounds Seminar | Lewis E. Kay, PhD
    Thurs, December 9, 2021 • Noon | Virtual on BlueJeans
    The importance of protein dynamics in health and disease
  • Friday Research Discussions | Cherry & Kohli Labs
    Fri, December 10, 2021 • 4pm | Virtual on BlueJeans
    Iulia Tapescu (Cherry Lab) & Juan Serrano (Kohli Lab)
  • Faculty Search Seminar | Daniel L. Kober, PhD
    Tues, December 14, 2021 • 2:00pm | BRB Gaulton Auditorium
    †††A metabolomics pipeline for the mechanistic interrogation of the gut microbiome

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Faculty Spotlight

James Shorter

ShorterJames Shorter is a Professor in the Department. The Shorter lab uses diverse techniques to pioneer protein disaggregases, small-molecule drugs, and RNAs to counter deleterious phase transitions in neurodegenerative disease. In an exciting study published in eLife, Dr. Shorter and colleagues discovered a human mitochondrial protein disaggregase, Skd3 (human ClpB), which is a AAA+ protein related to Hsp104. Skd3 maintains the solubility of several critical mitochondrial proteins. Importantly, Skd3 variants linked to 3-methylglutaconic aciduria, a severe mitochondrial disorder, display diminished disaggregase activity, which predicts disease severity. Moreover, in a recent study published in Blood, dominant-negative mutations in Skd3 were connected to severe congenital neutropenia. Thus, Skd3 is a potent protein disaggregase critical for human health.

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