Welcome to the Department of Biochemistry and Biophysics
As one of the first departments of Biochemistry and Biophysics in the nation, we are proud of our strong tradition of combining cutting-edge technology with impactful biology. We continue to leverage this interdisciplinary approach to yield break-through discoveries in biomedicine.
Our faculty of over 30 primary and secondary members cover a broad range of research areas, with particular strengths in structural biology, chemical biology, gene regulation and protein folding.
We are also the proud home of the Eldridge Reeves Johnson Research Foundation which offers advanced physical instrumentation and instruction to researchers across campus.
We are actively growing, with several recent hires, and our faculty are broadly engaged across campus with many joint appointments in other departments, institutes and centers.
We welcome you to learn more about our department in the following pages or contact us.
News & Publications
- Liu Lab in Proc Natl Acad Sci
Coordination of mRNA and tRNA Methylations by TRMT10A
- Lynch Lab in Nucleic Acids Research
Reciprocal regulation of hnRNP C and CELF2 through translation and transcription tunes splicing activity in T cells
- Shorter Lab studies on YouTube
Janet Iwasa’s animation of ClpP mechanism based on work from the Shorter lab
- Vera Moiseenkova-Bell Biophysical Society Profile
Moiseekova-Bell shares highlights of her professional and personal background.
Seminars & Events
Kushol Gupta is a Research Assistant Professor in the department, a member of the BMB graduate group, and directs the Johnson Foundation Structural Biology and Biophysics Core, a departmental resource that serves Penn and the greater region.
He is a structural biologist with expertise in both X-ray crystallography and solution biophysical methods, including small-angle X-ray and neutron scattering, light scattering, and analytical ultracentrifugation. His ongoing research focuses on retroviral integrases, their interaction with host factors, and a new class of drugs known as allosteric inhibitors of integrase (ALLINIs), which are potent antivirals against HIV. His research also includes other projects in the areas of phenylketonuria, RNA splicing, and site-specific recombination, highlighting the collaborative nature of research at Penn.
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