Welcome to the Department of Biochemistry and Biophysics
Chair
Vice Chair
As one of the first departments of Biochemistry and Biophysics in the nation, we are proud of our strong tradition of combining cutting-edge technology with impactful biology. We continue to leverage this interdisciplinary approach to yield break-through discoveries in biomedicine.
Our faculty of over 30 primary and secondary members cover a broad range of research areas, with particular strengths in structural biology, chemical biology, gene regulation and protein folding.
We are also the proud home of the Eldridge Reeves Johnson Research Foundation which offers advanced physical instrumentation and instruction to researchers across campus.
We are actively growing, with several recent hires, and our faculty are broadly engaged across campus with many joint appointments in other departments, institutes and centers.
We welcome you to learn more about our department in the following pages or contact us.
News & Publications
- Vinogradov Lab in Nanoscale
January 2020
In vivo deep-tissue microscopy with UCNP/Janus-dendrimers as imaging probes: resolution at depth and feasibility of ratiometric sensing - Dreyfuss Lab in Nature Communications
January 2020
U1 snRNP regulates cancer cell migration and invasion in vitro - Garcia Lab in Journal of the American Society for Mass Spectrometry
December 2019
Quantitation of Single and Combinatorial Histone Modifications by Integrated Chromatography of Bottom-up Peptides and Middle-down Polypeptide Tails - Shorter and Englander Labs in JBC
December 2019
Structural and mechanistic insights into Hsp104 function revealed by synchrotron x-ray footprinting
Seminars & Events
- Special Seminar | Yana Bromberg, PhD
Mon, January 27 • 12:00 noon | Class of 1962 Auditorium, John Morgan Bldg
Beyond conservation: Defining ranges of protein residue mutability - Raiziss Rounds Seminar | David Pellman, MD
Thurs, January 30 • 12:00 noon | Austrian Auditorium, CRB
Mechanisms driving rapid genome evolution - Friday Research Discussion | Marmorstein Lab
Fri, January 24 • 3:30 pm | JF Library, 2nd Floor Anatomy-Chemistry Bldg
Molecular mechanisms of the HIRA histone chaperone complex
Faculty Spotlight
Sara Cherry
Sara Cherry is a Professor with appointments in the Departments of Pathology and Laboratory Medicine, Microbiology, and Biochemistry and Biophysics. She is also a Faculty Director for the High Throughput Screening Core and the Director of the Program for Chemogenomics Discovery.
Dr. Cherry’s laboratory has pioneered the use of RNAi technology and other cell-based screening approaches to discover mechanisms by which diverse viral pathogens hijack cellular machinery while evading defenses. Her laboratory has discovered new factors involved in viral entry, translation, RNA replication and RNA stability. She has discovered new antiviral innate defenses against these emerging viruses and uncovered connections between metabolic regulation, the microbiota and immune defense. Recently, Dr. Cherry has expanded her interests to cancer where she has developed a functional precision pipeline as part of the Chemogenomics Discovery Program to screen acute leukemia cells for their sensitivities to drugs, with an eye toward guiding precision medicine patient therapy.
© The Trustees of the University of Pennsylvania | Site best viewed in a supported browser. | Report Accessibility Issues and Get Help | Site Design: PMACS Web Team.