Recent Select Publications

2024

Jeffrey D Levengood, Davit Potoyan, Srinivasa Penumutchu, Abhishek Kumar, Qianzi Zhou, Yiqing Wang, Alexandar L Hansen, Sebla Kutluay, Julien Roche, Blanton S Tolbert. Thermodynamic coupling of the tandem RRM domains of hnRNP A1 underlie its pleiotropic RNA binding functions. Sci Avd. 2024 July 12. 

PMID: 38985864

Wenjing Zong, Elliot S Friedman, Srinivasa Rao Allu, Jenni Firrman, Vincent Tu, Scott G Daniel, Kyle Bittinger, LinShu Liu, Sergei A Vinogradov, Gary D Wu. Disruption of intestinal oxygen balance in acute colitis alters the gut microbiome. Gut Microbes. 2024 July 3. 

PMID: 38958039

Trevor Griesman, Cynthia M. McMillen, Seble Getenet Negatu, Jesse J. Hulahan, Kanupriya Whig, Lenka Dohnalová, Mark Dittmar, Christoph A. Thaiss, Kellie A. Jurado, David C. Schultz, Amy L. Hartman, Sara Cherry. The lipopeptide Pam3CSK4 inhibits Rift Valley fever virus infection and protects from encephalitis. PLoS Pathog. 2024 June 27. 

PMID: 38935789

Hee Jong Kim, Mary R Szurgot, Trevor van Eeuwen, M Daniel Ricketts, Pratik Basnet, Athena L Zhang, Austin Vogt, Samah Sharmin, Craig D Kaplan, Benjamin A Garcia, Ronen Marmorstein, Kenji Murakami. Structure of the Hir histone chaperone complex. Mol Cell. 2024 June 20. 

PMID: 38925115

Julianna G Supplee, Hayley C Affronti, Richard Duan, Rebekah C Brooks, Zachary E Stine, Phuong T T Nguyen, Laura V Pinheiro, Michael C Noji, Jack M Drummond, Kevin Huang, Kollin Schultz, Chi V Dang, Ronen Marmorstein, Kathryn E Wellen. ACLY alternative splicing correlates with cancer phenotypes. J Biol Chem. 2024 May 28. 

PMID: 38815867

Michael B. Cory, Allen Li, Christina M. Hurley, Peter J. Carman, Ruth A. Pumroy, Zachary M. Hostetler, Ryann M. Perez, Yarra Venkatesh, Xinning Li, Kushol Gupta, E. James Petersson & Rahul M. Kohli. The LexA-RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation. Nat Struct Mol Biol. 2024 May 16. 

PMID: 38755298

Davia Blake, Matthew R. Gazzara, Isabel Breuer, Max Ferretti & Kristen W. Lynch. Alternative 3'UTR expression induced by T cell activation is regulated in a temporal and signal dependent manner. Sci Rep. 2024 May 14. 

PMID: 38745101

Neha Vithani, Tyson D Todd, Sukrit Singh, Tony Trent, Kendall J Blumer, Gregory R Bowman. G Protein Activation Occurs via a Largely Universal Mechanism. J Phys Chem B. 2024 April 5. 

PMID: 38580321

Benjamin C Creekmore, Kathryn Kixmoeller, Ben E Black, Edward B Lee, Yi-Wei Chang. Ultrastructure of human brain tissue vitrified from autopsy revealed by cryo-ET with cryo-plasma FIB milling. Nat Commun. 2024 March 26. 

PMID: 38531877

Craig W Gambogi, Gabriel J Birchak, Elie Mer, David M Brown, George Yankson, Kathryn Kixmoeller, Janardan N Gavade, Josh L Espinoza, Prakriti Kashyap, Chris L Dupont, Glennis A Logsdon, Patrick Heun, John I Glass, Ben E Black. Efficient formation of single-copy human artificial chromosomes. Science. 2024 March 21. 

PMID: 38513017

Nikaela W Bryan, Aamir Ali, Ewa Niedzialkowska, Leland Mayne, P Todd Stukenberg, Ben E Black. Structural basis for the phase separation of the chromosome passenger complex. Elife. 2024 March 8. 

PMID: 38456462

Hayley L Rein, Kara A Bernstein. Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site. DNA Repair. 2024 March 1. 

PMID: 38330859

Christopher M Bourne, Cornelius Y Taabazuing. Harnessing Pyroptosis for Cancer Immunotherapy. Cells. 2024 February 16. 

PMID: 38391959

Jesse Davila-Calderon, Mei-Ling Li, Srinivasa R Penumutchu, Christina Haddad, Linzy Malcolm, Josephine King, Amanda E Hargrove, Gary Brewer, Blanton S Tolbert. Enterovirus evolution reveals the mechanism of an RNA-targeted antiviral and determinants of viral replication. Sci Adv. 2024 February 16. 

PMID: 38363831

Artur Meller, Devin Kelly, Louis G Smith, Gregory R Bowman. Toward physics-based precision medicine: Exploiting protein dynamics to design new therapeutics and interpret variants. Protein Sci. 2024 February 15. 

PMID: 38358129

Nicole R Raniszewski, Jenna N Beyer, Myles I Noel, George M Burslem. Sortase mediated protein ubiquitination with defined chain length and topology. RCS Chem Biol. 2024 February 7. 

PMID: 38576722

Katelyn M. Sweeney, Sapanna Chantarawong, Edward M. Barbieri, Greg Cajka, Matthew Liu, Lynn Spruce, Hossein Fazelinia, Bede Portz, Katie Copley, Tomer Lapidot, Lauren Duhamel, Phoebe Greenwald, Naseeb Saida, Reut Shalgi, James Shorter, Ophir Shalem. CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. PLoS Genet. 2024 February 5. 

PMID: 38315730

Hayley L Rein, Kara A Bernstein. Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site. DNA Repair. 2024 February 1. 

PMID: 38330859

Dian Ding, Ziyuan Fang, Seohyun Chris Kim, Derek K. O’Flaherty, Xiwen Jia, Talbot B. Stone, Lijun Zhou, Jack W. Szostak. Unusual Base Pair between Two 2‑Thiouridines and Its Implication for Nonenzymatic RNA Copying. J Am Chem Soc. 2024 January 31. 

PMID: 38293747

Louis G Smith, Borna Novak, Meghan Osato, David L Mobley, Gregory R Bowman. PopShift: A Thermodynamically Sound Approach to Estimate Binding Free Energies by Accounting for Ligand-Induced Population Shifts from a Ligand-Free Markov State Model. J Chem Theory Comput. 2024 January 31. 

PMID: 38291966

Kiara N Berríos, Aleksia Barka, Jasleen Gill, Juan C Serrano, Peter F Bailer, Jared B Parker, Niklaus H Evitt, Kiran S Gajula, Junwei Shi, Rahul M Kohli. Cooperativity between Cas9 and hyperactive AID establishes broad and diversifying mutational footprints in base editors. Nucleic Acids Res. 2024 January 24. 

PMID: 38261989

Daniel C Akuma, Kimberly A Wodzanowski, Ronit Schwartz Wertman, Patrick M Exconde, Víctor R Vázquez Marrero, Chukwuma E Odunze, Daniel Grubaugh, Sunny Shin, Cornelius Taabazuing, Igor E Brodsky. Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS. Elife. 2024 January 17. 

PMID: 38231198

Nicolas Dos Santos Pacheco, Albert Tell i Puig, Amandine Guérin, Matthew Martinez, Bohumil Maco, Nicolò Tosetti, Estefanía Delgado-Betancourt, Matteo Lunghi, Boris Striepen, Yi-Wei Chang & Dominique Soldati-Favre. Sustained rhoptry docking and discharge requires Toxoplasma gondii intraconoidal microtubule-associated proteins. Nat Commun. 2024 January 9. 

PMID: 38191574

Matthew N Gaynes, Trey A Ronnebaum, Kollin Schultz, Jacque L Faylo, Ronen Marmorstein, David W Christianson. Structure of the prenyltransferase in bifunctional copalyl diphosphate synthase from Penicillium fellutanum reveals an open hexamer conformation. J Struct Biol. 2024 January 5. 

PMID: 38184156

Leon Palao 3rd, Kenji Murakami, Yi-Wei Chang. Combining per-particle cryo-ET and cryo-EM single particle analysis to elucidate heterogeneous DNA-protein organization. Curr Opin Struct Biol. 2024 January 4. 

PMID: 38181688

2023

Sudeshi M Abedeera, Jesse Davila-Calderon, Christina Haddad, Barrington Henry, Josephine King, Srinivasa Penumutchu, Blanton S Tolbert. The Repurposing of Cellular Proteins during Enterovirus A71 Infection. Viruses. 2023 December 31. 

PMID: 38257775

Patrick M Exconde, Claudia Hernandez-Chavez, Christopher M Bourne, Rachel M Richards, Mark B Bray, Jan L Lopez, Tamanna Srivastava, Marisa S Egan, Jenna Zhang, William Yoo, Sunny Shin, Bohdana M Discher, Cornelius Y Taabazuing. The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases. Cell Rep. 2023 December 26. 

PMID: 38103201

José J De Jesús-Pérez, Matthew Gabrielle, Sumiyya Raheem, Edwin C Fluck, Tibor Rohacs, Vera Y Moiseenkova-Bell. Structural mechanism of TRPV5 inhibition by econazole. Structure. 2023 December 19. 

PMID: 38141613

Andrew C McShan, David Flores-Solis, Yi Sun, Samuel E Garfinkle, Jugmohit S Toor, Michael C Young, Nikolaos G Sgourakis. Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition. Nat Commun. 2023 December 11. 

PMID: 38081856

Yi Sun, Tyler J Florio, Sagar Gupta, Michael C Young, Quinlen F Marshall, Samuel E Garfinkle, Georgia F Papadaki, Hau V Truong, Emily Mycek, Peiyao Li, Alvin Farrel, Nicole L Church, Shereen Jabar, Matthew D Beasley, Ben R Kiefel, Mark Yarmarkovich, Leena Mallik, John M Maris, Nikolaos G Sgourakis. Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion. Sci Immunol. 2023 December 1. 

PMID: 38039376

Timothé Maujean, Prakash Kannaboina, Adam I Green, George M Burslem. Lead-oriented synthesis of epigenetic relevant scaffolds. Chem Commun. 2023 November 22. 

PMID: 37991354

Craig W Gambogi, Nootan Pandey, Jennine M Dawicki-McKenna, Uma P Arora, Mikhail A Liskovykh, Jun Ma, Piero Lamelza, Vladimir Larionov, Michael A Lampson, Glennis A Logsdon, Beth L Dumont, Ben E Black. Centromere innovations within a mouse species. Sci Adv. 2023 November 17. 

PMID: 37967185

Iulia Tapescu, Frances Taschuk, Swechha M Pokharel, Oleksandr Zginnyk, Max Ferretti, Peter F Bailer, Kanupryia Whig, Emily A Madden, Mark T Heise, David C Schultz, Sara Cherry. The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection. Mol Cell. 2023 November 16. 

PMID: 37949067

M Hannah Choi, Liu Hong, Leonardo P Chamorro, Boyd Edwards, Aaron T Timperman. Measuring the electrophoretic mobility and size of single particles using microfluidic transverse AC electrophoresis (TrACE). Lab Chip. 2023 November 8. 

PMID: 37937351

Jean M Etersque, Iris K Lee, Nitika Sharma, Kexiang Xu, Andrew Ruff, Justin D Northrup, Swarbhanu Sarkar, Tommy Nguyen, Richard Lauman, George M Burslem, Mark A Sellmyer. Regulation of eDHFR-tagged proteins with trimethoprim PROTACs. Nat Commun. 2023 November 3. 

PMID: 37923771

Iulia Tapescu, Frances Taschuk, Swechha M Pokharel, Oleksandr Zginnyk, Max Ferretti, Peter F Bailer, Kanupryia Whig, Emily A Madden, Mark T Heise, David C Schultz, Sara Cherry. 1The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection. Mol Cell. 2023 November 2. 

PMID: 37949067

Iris K Lee, Nitika Sharma, Estela Noguera-Ortega, Maria Liousia, Miren L Baroja, Jean M Etersque, Jonathan Pham, Swarbhanu Sarkar, Beatriz M Carreno, Gerald P Linette, Ellen Puré, Steven M Albelda, Mark A Sellmyer. A genetically-encoded protein tag for control and quantitative imaging of CAR T cell therapy. Mol Ther. 2023 November 1. 

PMID: 37919903

Sagar Gupta, Santrupti Nerli, Sreeja Kutti Kandy, Glenn L Mersky, Nikolaos G Sgourakis. HLA3DB: comprehensive annotation of peptide/HLA complexes enables blind structure prediction of T cell epitopes. Nat Commun. 2023 October 10. 

PMID: 37816745

Jennifer Ramirez, Samantha X Pancoe, Elizabeth Rhoades, E James Petersson. The Effects of Lipids on α-Synuclein Aggregation In Vitro. Biomolecules. 2023 October 2. 

PMID: 37892158

Raghavendar R Sanganna Gari, Grigory Tagiltsev, Ruth A Pumroy, Yining Jiang, Martin Blackledge, Vera Y Moiseenkova-Bell, Simon Scheuring. Intrinsically disordered regions in TRPV2 mediate protein-protein interactions. Commun Biol. 2023 September 22. 

PMID: 37736816

Melissa Birol, Isabella Ioana Douzoglou Muñoz, Elizabeth Rhoades. The C-terminus of α-Synuclein regulates its dynamic cellular internalization by Neurexin 1β. Mol Biol Cell. 2023 September 20. 

PMID: 37729016

Mirna El Khatib, Azar O Motlagh, Jenna N Beyer, Thomas Troxler, Srinivasa Rao Allu, Qi Sun, George M Burslem, Sergei A Vinogradov. Direct Measurements of FLASH-Induced Changes in Intracellular Oxygenation. Int J Radiat Oncol Biol Phys. 2023 September 18. 

PMID: 37729972

Korrie L. Mack, Hanna Kim, Edward M. Barbieri, JiaBei Lin, Sylvanne Braganza, Meredith E. Jackrel, Jamie E. DeNizio, Xiaohui Yan, Edward Chuang, Amber Tariq, Ryan R. Cupo, Laura M. Castellano, Kim A. Caldwell, Guy A. Caldwell, James Shorter. Tuning Hsp104 specificity to selectively detoxify α-synuclein. Mol Cell. 2023 August 24. 

PMID: 37625404

Matthew Martinez, Shrawan Kumar Mageswaran, Amandine Guérin, William David Chen, Cameron Parker Thompson, Sabine Chavin, Dominique Soldati-Favre, Boris Striepen, Yi-Wei Chang. Origin and arrangement of actin filaments for gliding motility in apicomplexan parasites revealed by cryo-electron tomography. Nat Commun. 2023 August 9. 

PMID: 37558667

Arunika Das, Katelyn G Boese, Kikue Tachibana, Sung Hee Baek, Michael A Lampson, Ben E Black. Centromere-specifying nucleosomes persist in aging mouse oocytes in the absence of nascent assembly. Curr Biol. 2023 August 4. 

PMID: 37582374

Georgia F Papadaki, Claire H Woodward, Michael C Young, Trenton J Winters, George M Burslem, Nikolaos G Sgourakis. A Chicken Tapasin ortholog can chaperone empty HLA-B*37:01 molecules independent of other peptide-loading components. J Biol Chem. 2023 August 3. 

PMID: 37543367

Tong Wang, Johanna M Fowler, Laura Liu, Christian E Loo, Meiqi Luo, Emily K Schutsky, Kiara N Berríos, Jamie E DeNizio, Ashley Dvorak, Nick Downey, Saira Montermoso, Bianca Y Pingul, MacLean Nasrallah, Walraj S Gosal, Hao Wu, Rahul M Kohli. Direct enzymatic sequencing of 5-methylcytosine at single-base resolution. Nat Chem Biol. 2023 June 15. 

PMID: 37322153

Buyan Pan, Sarah M Gardner, Kollin Schultz, Ryann M Perez, Sunbin Deng, Marie Shimogawa, Kohei Sato, Elizabeth Rhoades, Ronen Marmorstein, E James Petersson. Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies. J Am Chem Soc. 2023 June 15. 

PMID: 37319422

Yi Sun, Michael C. Young, Claire H. Woodward, Julia N. Danon, Hau V. Truong, Sagar Gupta, Trenton J. Winters, Joan Font-Burgada, George M. Burslem, Nikolaos G. Sgourakis. Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes. PNAS. 2023 June 13. 

PMID: 37310998

Xuepeng Wei, Kollin Schultz, Hannah L Pepper, Emily Megill, Austin Vogt, Nathaniel W Snyder, Ronen Marmorstein. Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun. 2023 April 19. 

PMID: 37076498

Xiangrui Zeng, Anson Kahng, Liang Xue, Julia Mahamid, Yi-Wei Chang, Min Xu. High-throughput cryo-ET structural pattern mining by unsupervised deep iterative subtomogram clustering. Proc Natl Acad Sci U S A. 2023 April 7. 

PMID: 37027429

Yulia Gonskikh, Julian Stoute, Hui Shen, Krista Budinich, Bianca Pingul, Kollin Schultz, Heidi Elashal, Ronen Marmorstein, Junwei Shi, Kathy Fange Liu. Noncatalytic regulation of 18 S rRNA methyltransferase DIMT1 in acute myeloid leukemia. Genes Dev. 2023 April 6. 

PMID: 37024283

Hannah Hyun-Sook Kim, Mostofa Rafid Uddin, Min Xu, Yi-Wei Chang. Computational methods toward unbiased pattern mining and structure determination in cryo-electron tomography data. J Mol Biol. 2023 March 30. 

PMID: 37003470

Michael B Cory, Chloe M Jones, Kyle D Shaffer, Yarra Venkatesh, Sam Giannakoulias, Ryann M Perez, Marshall G Lougee, Eshe Hummingbird, Vinayak V Pagar, Christina M Hurley, Allen Li, Robert H Mach, Rahul M Kohli, E James Petersson. FRETing About the Details: Case studies in the use of a genetically encoded fluorescent amino acid for distance-dependent energy transfer. Protein Sci. 2023 March 28. 

PMID: 36974585

Artur Meller, Soumendranath Bhakat, Shahlo Solieva, Gregory R Bowman. Accelerating Cryptic Pocket Discovery Using AlphaFold. J Chem Theory Comput. 2023 March 22. 

PMID: 36948209

Laura M Agosto, Michael J Mallory, Max B Ferretti, Davia Blake, Keegan S Krick, Matthew R Gazzara, Benjamin A Garcia, Kristen W Lynch. Alternative splicing of HDAC7 regulates its interaction with 14-3-3 proteins to alter histone marks and target gene expression. Cell Rep. 2023 March 17. 

PMID: 36933216

Grant Eilers, Kushol Gupta, Audrey Allen, Saira Montermoso, Hemma Murali, Robert Sharp, Young Hwang, Frederic D. Bushman, Gregory Van Duyne. Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization. PLoS Pathog. 2023 March 3

PMID: 36867659

Artur Meller, Michael Ward, Jonathan Borowsky, Meghana Kshirsagar, Jeffrey M Lotthammer, Felipe Oviedo, Juan Lavista Ferres, Gregory R Bowman. Predicting locations of cryptic pockets from single protein structures using the PocketMiner graph neural network. Nat Commun. 2023 March 1. 

PMID: 36859488

Longsheng Lai, Yee-Wai Cheung, Matthew Martinez, Kathryn Kixmoeller, Leon Palao III, Stefan Steimle, Meng-Chiao Ho, Ben E. Black, Erh-Min Lai & Yi-Wei Chang. In Situ Structure Determination of Bacterial Surface Nanomachines Using Cryo-Electron Tomography. Methods Mol Biol. 2023 February 27. 

PMID: 36842118

Charlotte M Fare, Kevin Rhine, Andrew Lam, Sua Myong, James Shorter. A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity. J Biol Chem. 2023 February 27. 

PMID: 36529289

Yi Sun, Georgia F Papadaki , Christine A Devlin, Julia N Danon, Michael C Young, Trenton J Winters, George M Burslem, Erik Procko, Nikolaos G Sgourakis. Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes. Sci Adv. 2023 Feburary 24. 

PMID: 36827371

Nancy Schek, Jia-Ying Lee, George M Burslem, Eric Witze. Chemical probe mediated visualization of protein S-palmitoylation in patient tissue samples. Front Physiol. 2023 February 21. 

PMID: 36895631

Kofi K. Acheampong, Dylan L. Schaff, Benjamin L. Emert, Jonathan Lake, Sam Reffsin, Emily K. Shea, Courtney E. Comar, Leslie A. Litzky, Nigar A. Khurram, Rebecca L. Linn, Michael Feldman, Susan R. Weiss, Kathleen T. Montone, Sara Cherry, Sydney M. Shaffer. Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar Macrophages. mBio. 2023 February 8. 

PMID: 35130722

Jose J Gorbea Colón, Leon Palao 3rd, Shin-Fu Chen, Hee Jong Kim, Laura Snyder, Yi-Wei Chang, Kuang-Lei Tsai, Kenji Murakami. Structural basis of a transcription pre-initiation complex on a divergent promoter. Mol Cell. 2023 January 26. 

PMID: 36731470

Artur Meller, Jeffrey M Lotthammer, Louis G Smith, Borna Novak, Lindsey A Lee, Catherine C Kuhn, Lina Greenberg, Leslie A Leinwand, Michael J Greenberg, Gregory R Bowman. Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains. Elife. 2023 January 27. 

PMID: 36705568

Georgia F. Papadaki, Omar Ani, Tyler J. Florio, Michael C. Young, Julia N. Danon, Yi Sun, Devin Dersh, and Nikolaos G. Sgourakis. Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules. Front. Immunol. 2023 January 25. 

PMID: 36761745

2022

Sunbin Deng, Sarah M Gardner, Leah Gottlieb, Buyan Pan, E James Petersson, and Ronen Marmorstein. Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase. Structure. 2022 December 30. 

PMID: 36638802

Juan C. Serrano, Dora von Trentini, Kiara N. Berríos, Aleksia Barka, Ivan J. Dmochowski, and Rahul M. Kohli. Structure-Guided Design of a Potent and Specific Inhibitor against the Genomic Mutator APOBEC3A. ACS Chem. Biol. 2022 December 8. 

PMID: 36475588

Michael B. Cory, Allen Li, Christina M. Hurley, Zachary M. Hostetler, Yarra Venkatesh, Chloe M. Jones, E. James Petersson, and Rahul M. Kohli. Engineered RecA Constructs Reveal the Minimal SOS Activation Complex. Biochemistry. 2022 December 6. 

PMID: 36473084

Alisa Cario, Sanjula P Wickramasinghe, Elizabeth Rhoades, Christopher L Berger. The N-terminal disease-associated R5L Tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound Tau patches. J Biol Chem. 2022 November 29. 

PMID: 36162501

Sang Hoon Chong, Yi Hong Ong, Mirna El Khatib, Srinivasa Rao Allu, Ashwin B Parthasarathy, Joel H Greenberg, Arjun G Yodh, Sergei A Vinogradov. Real-time tracking of brain oxygen gradients and blood flow during functional activation. Neurophotonics. 2022 November 28. 

PMID: 36457848

Dayi Chen and Aaron T. Timperman. Analyte Enrichment via Ion Concentration Polarization with Hydrogel Plugs Polymerized in PDMS Microchannels by a Facile and Comprehensive Method for Improved Polymerization. Anal. Chem. 2022 November 1. 

PMID: 36318671

M Daniel Ricketts, Ryan P Emptage, Gerd A Blobel, Ronen Marmorstein. The heme-regulated inhibitor kinase requires dimerization for heme-sensing activity. J Biol Chem. 2022 October 29. 

PMID: 36063997

Davia Blake, Caleb M Radens, Max B Ferretti, Matthew R Gazzara, Kristen W Lynch. Alternative splicing of apoptosis genes promotes human T cell survival. Elife. 2022 October 20. 

PMID: 36264057

Natoya J Peart, Jae Yeon Hwang, Mathieu Quesnel-Vallières, Matthew J Sears, Yuequin Yang, Peter Stoilov, Yoseph Barash, Juw Won Park, Kristen W Lynch, Russ P Carstens. The global Protein-RNA interaction map of ESRP1 defines a post-transcriptional program that is essential for epithelial cell function. iScience. 2022 October 21. 

PMID: 36238894

Daniela Sparvoli, Jason Delabre, Diana Marcela Penarete-Vargas, Shrawan Kumar Mageswaran, Lev M Tsypin, Justine Heckendorn, Liam Theveny, Marjorie Maynadier, Marta Mendonça Cova, Laurence Berry-Sterkers, Amandine Guérin, Jean-François Dubremetz, Serge Urbach, Boris Striepen, Aaron P Turkewitz, Yi-Wei Chang, Maryse Lebrun. An apical membrane complex for triggering rhoptry exocytosis and invasion in Toxoplasma. EMBO J. 2022 October 17. 

PMID: 36245278

Fares Saïdi, Utkarsha Mahanta, Adyasha Panda, Ahmad A Kezzo, Nicolas Y Jolivet, Razieh Bitazar, Gavin John, Matthew Martinez, Abdelkader Mellouk, Charles Calmettes, Yi-Wei Chang, Gaurav Sharma, Salim T Islam. Bacterial Outer Membrane Polysaccharide Export (OPX) Proteins Occupy Three Structural Classes with Selective β-Barrel Porin Requirements for Polymer Secretion. Microbiol Spectr. 2022 October 6. 

PMID: 36200915

Ryan R. Cupo, Alexandrea N. Rizo, Gabriel A. Braun, Kushol Gupta, Daniel R. Southworth, James Shorter. Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3. Cell Reports. 2022 September 27. 

DOI: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01249-9 

Tatjana Weil, Abbna Kirupakaran, My-Hue Le, Philipp Rebmann, Joel Mieres-Perez, Leila Issmail, Carina Conzelmann, Janis A. Müller, Lena Rauch, Andrea Gilg, Lukas Wettstein, Rüdiger Groß, Clarissa Read, Tim Bergner, Sandra Axberg Pålsson, Nadja Uhlig, Valentina Eberlein, Heike Wöll, Frank-Gerrit Klärner, Steffen Stenger, Beate M. Kümmerer, Hendrik Streeck, Giorgio Fois, Manfred Frick, Peter Braubach, Anna-Lena Spetz, Thomas Grunwald, James Shorter, Elsa Sanchez-Garcia, Thomas Schrader, and Jan Münch. Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au. 2022 September 6. 

JACS 2187-2202

Thong T Luong, Zheqi Li, Nolan Priedigkeit, Phoebe S Parker, Stefanie Böhm, Kyle Rapchak, Adrian V Lee, Kara A Bernstein. Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer. PLos Genet. 2022 September 20. 

PMID: 36126066

Alexandra E. Perlegos, Emily J. Shields, Hui Shen, Kathy Fange Liu, Nancy M. Bonini. Mettl3-dependent m6A modification attenuates the brain stress response in Drosophila. Nat Commun. 2022 September 14. 

PMID: 36104353

Shoumei Bai, Sarah E Taylor, Mohd Azrin Jamalruddin, Stacy McGonigal, Edward Grimley, Dongli Yang, Kara A Bernstein, Ronald J Buckanovich. Targeting Therapeutic Resistance and Multinucleate Giant Cells in CCNE1-Amplified HR-Proficient Ovarian Cancer. Mol. Cancer Ther. 2022 September 6. 

PMID: 35732503

Yang Mei, Troy E Messick, Jayaraju Dheekollu, Hee Jong Kim, Sudheer Molugu, Leonardo Josué Castro Muñoz, Vera Moiskeenkova-Bell, Kenji Murakami, Paul M Lieberman. Cryo-EM Structure and Functional Studies of EBNA1 Binding to the Family of Repeats and Dyad Symmetry Elements of Epstein-Barr Virus oriP. J. Virol. 2022 August 29. 

PMID: 36037477

Mirna El Khatib, Andrei V. Cheprakov, and Sergei A. Vinogradov. Unusual Reactivity and Metal Affinity of Water-Soluble Dipyrrins. Inorg Chem. 2022 August 2. 

PMID: 35917291

Papita Mandal, Karthik Eswara, Zhadyra Yerkesh, Vladlena Kharchenko, Levani Zandarashvili, Kacper Szczepski, Dalila Bensaddek, Łukasz Jaremko, Ben E Black, Wolfgang Fischle. Molecular basis of hUHRF1 allosteric activation for synergistic histone modification binding by PI5P. Sci Adv. 2022 August 26. 

PMID: 36001657

Alexander J. Polino, Justin J. Miller, Soumendranath Bhakat, Suhas Bobba, Gregory R. Bowman, Daniel E. Goldberg. The nepenthesin insert in the Plasmodium falciparum aspartic protease plasmepsin V is necessary for enzyme function. J Biol Chem. 2022 August 8
PMID: 35972732

Iris K Lee, Estela Noguera-Ortega, Zebin Xiao, Leslie Todd, John Scholler, Decheng Song, Maria Liousia, Katheryn Lohith, Kexiang Xu, Kimberly J Edwards, Michael D Farwell, Carl H June, Steven M Albelda, Ellen Pure, Mark A Sellmyer. Monitoring Therapeutic Response to Anti-Fibroblast Activation Protein (FAP) CAR T Cells using [18F]AlF-FAPI-74. Clin Cancer Res. 2022 August 16
PMID: 35972732

Kimberly J Edwards, Bryan Chang, Hasan Babazada, Katheryn Lohith, Daniel H Park, Michael D Farwell, Mark A Sellmyer. Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation. Cancer Immunol Res. 2022 July 21
PMID: 35862229

Xuepeng Wei, Kathryn Kixmoeller, Elana Baltrusaitis, Xiaolu Yang, Ronen Marmorstein. Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity. Proc Natl Acad Sci U S A. 2022 July 19
PMID: 35858355

Andrew C. McShan, Christine A. Devlin, Georgia F. Papadaki, Yi Sun, Adam I. Green, Giora I. Morozov, George M. Burslem, Erik Procko, Nikolaos G. Sgourakis. TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules. Nat Chem Biol. 2022 June 20
PMID: 35725941

Eva Erlebach, Luca Ravotto, Matthias T Wyss, Jacqueline Condrau, Thomas Troxler, Sergei A Vinogradov, Bruno Weber. Measurement of cerebral oxygen pressure in living mice by two-photon phosphorescence lifetime microscopy. STAR Protoc. 2022 June 17 

PMID: 35573482

Mirna El Khatib, Alexander L. Van Slyke, Anastasia Velalopoulou, Michele M. Kim, Khayrullo Shoniyozov, Srinivasa Rao Allu, Eric E. Diffenderfer, Theresa M. Busch, Rodney D. Wiersma, Cameron J. Koch, Sergei A. Vinogradov. Ultrafast Tracking of Oxygen Dynamics during Proton FLASH. Int J Radiat Oncol Biol Phys. 2022 Mar 18
PMID: 35314293

David C. Schultz, Robert M. Johnson, Kasirajan Ayyanathan, Jesse Miller, Kanupriya Whig, Brinda Kamalia, Mark Dittmar, Stuart Weston, Holly L. Hammond, Carly Dillen, Jeremy Ardanuy, Louis Taylor, Jae Seung Lee, Minghua Li, Emily Lee, Clarissa Shoffler, Christopher Petucci, Samuel Constant, Marc Ferrer, Christoph A. Thaiss, Matthew B. Frieman, Sara Cherry. Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2. Nature. 2022 Feb 7
PMID: 35130559 

Chun Yang, Rina Fujiwara, Hee Jong Kim, Pratik Basnet, Yunye Zhu, Jose J Gorbea Colón, Stefan Steimle, Benjamin A Garcia, Craig D Kaplan, Kenji Murakami. Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II. Mol Cell. 2022 Jan 11;S1097-2765(21)01082-0
PMID: 35051353

 

2021

Elisha Segrist, Mark Dittmar, Beth Gold, Sara Cherry. Orally acquired cyclic dinucleotides drive dSTING-dependent antiviral immunity in enterocytes. Cell Rep. 2021 Dec 28;37(13):110150
PMID: 34965418

Marie-France Langelier, Ramya Billur, Aleksandr Sverzhinsky, Ben E. Black, John M. Pascal. HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications. Nat Commun. 2021 Nov 18;12(1):6675
PMID: 34795260

Catalina Salinas-Luypaert, Praveen Kumar Allu, Glennis A Logsdon, Jennine M. Dawicki-McKenna, Craig W. Gambogi, Daniele Fachinetti, Ben E. Black. Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-A K124ubCell Rep. 2021 Nov 2;37(5):109924
PMID: 34731637

Leah Gottlieb, Lin Guo, James Shorter, Ronen Marmorstein. N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate. J Biol Chem. 2021 Oct 31;101363
PMID: 34732320

Michael Grasso, Gavin J. Bond, Ye-Jin Kim, Stefanie Boyd, Maria Matson Dzebo, Sebastian Valenzuela, Tiffany Tsang, Natalie A. Schibrowsky, Katherine B. Alwan, Ninian J. Blackburn, George M. Burslem, Pernilla Wittung-Stafshede, Duane D. Winkler, Ronen Marmorstein, Donita C. Brady. The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation. J Biol Chem. 2021 Oct 26;101314.
PMID: 34715128

Kiara N Berríos, Niklaus H. Evitt, Rachel A. DeWeerd, Diqiu Ren, Meiqi Luo, Aleksia Barka, Tong Wang, Caroline R. Bartman, Yemin Lan, Abby M. Green, Junwei Shi, Rahul M Kohli. Controllable genome editing with split-engineered base editors. Nat Chem Biol. 2021 Oct 18
PMID: 34663942

Chloe M. Jones,  D. Miklos Robkis,  Robert J. Blizzard, Mika Munari, Yarra Venkatesh, Tiberiu S. Mihaila, Alex J. Eddins, Ryan A. Mehl, William N. Zagotta, Sharona E. Gordon and  E. James Petersson. Genetic encoding of a highly photostable, long lifetime fluorescent amino acid for imaging in mammalian cells. Chem. Sci., 2021, 12, 11955-11964
PMID to come

Hui Shen, Yulia Gonskikh, Julian Stoute, Kathy Fange Liu. Human DIMT1 generates N 26,6 A-dimethylation-containing small RNAs. J  Biol Chem. 2021 Aug 30.
PMID: 34473991

Hana M. Odeh, Charlotte M. Fare, James Shorter. Nuclear-import receptors counter deleterious phase transitions in neurodegenerative disease. J Mol Biol. 2021 Aug 28.
PMID: 34464655

Adam I. Green and George M. Burslem. Photochemical synthesis of an epigenetic focused tetrahydroquinoline library. RSC Med Chem. 2021 Aug 25;12(10):1780-1786
PMID: 34778779

Tofayel Ahmed, Collin R. Nisler, Edwin C. Fluck 3rd, Sanket Walujkar, Marcos Sotomayor, Vera Y. Moiseenkova-Bell. Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium. Structure. 2021 Aug 24. 
PMID: 34453887

Liangqian Huang, Trisha Agrawal, Guixin Zhu, Sixiang Yu, Liming Tao, JiaBei Lin, Ronen Marmorstein, James Shorter & Xiaolu Yang. DAXX represents a new type of protein-folding enabler. Nature. 2021 Aug 18.
PMID: to come

Shrawan Kumar Mageswaran, Amandine Guérin, Liam M Theveny, William David Chen, Matthew Martinez, Maryse Lebrun, Boris Striepen, Yi-Wei Chang. In situ ultrastructures of two evolutionarily distant apicomplexan rhoptry secretion systems. Nat Commun. 2021 Aug17;12(1):4983
PMID: 34404783

Martina Hallegger, Anob M. Chakrabarti, Flora C. Y. Lee, Bo Lim Lee, Aram G Amalietti, Hana M. Odeh, Katie E. Copley, Jack D. Rubien, Bede Portz, Klara Kuret, Ina Huppertz, Frédérique Rau, Rickie Patani, Nicolas L. Fawzi, James Shorter, Nicholas M. Luscombe, Jernej Ule. TDP-43 condensation properties specify its RNA-binding and regulatory repertoire. Cell. 2021 Aug 6.
PMID: 34380047

R. Alexander Martino, Edwin C. Fluck 3rd, Jacqueline Murphy, Qiang Wang, Henry Hoff, Ruth A. Pumroy, Claudia Y. Lee, Joshua J. Sims, Soumitra Roy, Vera Y. Moiseenkova-Bell, James M. Wilson. Context-Specific Function of the Engineered Peptide Domain of PHP.B. J Virol. 2021 Aug 4.
PMID: 34346767

Kushol Gupta, Ying Wen, Nisha S. Ninan, Amanda C. Raimer, Robert Sharp, Ashlyn M. Spring, Kathryn L. Sarachan, Meghan C. Johnson, Gregory D. Van Duyne, A. Gregory Matera. Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer. Nucleic Acids Res. 2021 Jul 21;49(13):7644-7664
PMID: 34181727

Trevor van Eeuwen, Yoonjung Shim, Hee Jong Kim, Tingting Zhao, Shrabani Basu, Benjamin A. Garcia, Craig D Kaplan, Jung-Hyun Min, Kenji Murakami. Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair. Nat Commun. 2021 Jun 7;12(1):3338.
PMID: 34099686

Scott Sherrill-Mix, Young Hwang, Aoife M. Roche, Abigail Glascock, Susan R. Weiss, Yize Li, Leila Haddad, Peter Deraska, Caitlin Monahan, Andrew Kromer, Jevon Graham-Wooten, Louis J. Taylor, Benjamin S. Abella, Arupa Ganguly, Ronald G. Collman, Gregory D. Van Duyne, Frederic D. Bushman. Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons. Genome Biol. 2021 Jun 3;22(1):169
PMID: 34082779

Adam I. Green, George M. Burslem. Focused Libraries for Epigenetic Drug Discovery: The Importance of Isosteres. J Med Chem. 2021 June 10;64(11):7231-7240. 
PMID: 34042449

Andrew C. McShan, Christine A. Devlin, Giora I. Morozov, Sarah A. Overall, Danai Moschidi, Neha Akella, Erik Procko & Nikolaos G. Sgourakis.  TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap. Nat Commun. 2021 May 26;12(1)
PMID: 34039964

Sunbin Deng, Leah Gottlieb, Buyan Pan, Julianna Supplee, Xuepeng Wei, E. James Petersson, Ronen Marmorstein. Molecular mechanism of N-terminal acetylation by the ternary NatC complex. Structure. 2021 May 15.
PMID: 34019809

David F. Wilson, Franz M. Matschinsky. Metabolic Homeostasis in Life as We Know It: Its Origin and Thermodynamic Basis. Front Physiol. 2021 Apr 23;12:658997
PMID: 33967829

Osvaldo D. Rivera, Michael .J Mallory, Mathieu Quesnel-Vallières, Rakesh Chatrikhi, David C. Schultz, Martin Carroll, Yoseph Barash, Sara Cherry, Kristen W. Lynch. Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia. Proc Natl Acad Sci USA. 2021 Apr 13 118(15)
PMID: 33876749

Lindsay K. Pino, Josue Baeza, Richard Lauman, Birgit Schilling, Benjamin A. Garcia. Improved SILAC Quantification with Data-Independent Acquisition to Investigate Bortezomib-Induced Protein Degradation. J Proteome Res. 2021 Mar 25
PMID: 33764077

Saravana G. Baskaran, Thayne P. Sharp, Kim A Sharp. Computational Graphics Software for Interactive Docking and Visualization of Ligand-Protein Complementarity. J Chem Inf Model. 2021 Mar 22;61(3):1427-1443.
PMID: 33656873

Stefan Steimle, Trevor van Eeuwen, Yavuz Ozturk, Hee Jong Kim, Merav Braitbard, Nur Selamoglu, Benjamin A Garcia, Dina Schneidman-Duhovny, Kenji Murakami, Fevzi Daldal. Cryo-EM structures of engineered active bc 1-cbb 3type CIII 2 CIV super-complexes and electronic communication between the complexes. Nat Commun. 2021 Feb 10;12(1):929.
PMID: 33568648

Santrupti Nerli, Viviane S. De Paula, Andrew C. McShan, Nikolaos G. Sgourakis. Backbone-independent NMR resonance assignments of methyl probes in large proteins. Nat Commun. 2021 Jan 29;12(1): 691
PMID 33514730

Daniel A. Jacome, Justin D. Northrup, Andrew J. Ruff, Sean W. Reilly, Iris K. Lee, Gabrielle S. Blizard, Mark A. Sellmyer. A Chemical Approach for Programmable Protein Outputs Based on Engineered Cell Interactions. ACS Chem. Biol. 2021 Jan 15;16(1): 52–57
PMID: 33351606


2020

Luca Ravotto, Stephen L Meloni, Tatiana V Esipova, Artëm E Masunov, Jessica M Anna, Sergei A Vinogradov. Three-Photon Spectroscopy of Porphyrins. J Phys Chem A. 2020 Dec 31;124(52)
PMID: 33337890

Buyan Pan, Naoki Kamo, Marie Shimogawa, Yun Huang, Anna Kashina, Elizabeth Rhoades, E. James Petersson. Effects of Glutamate Arginylation on α-Synuclein: Studying an Unusual Post-Translational Modification through Semisynthesis. J Am Chem Soc. 2020 Dec 30;142(52)
PMID: 33337869

Kushol Gupta, Audrey Allen, Carolina Giraldo, Grant Eilers, Robert Sharp, Young Hwang, Hemma Murali, Katrina Cruz, Paul Janmey, Frederic Bushman, Gregory D Van Duyne. Structure. 2020 Dec 23;S0969-2126(20)30468-8
PMID: 33357410

Zachary M March, Katelyn Sweeney, Hanna Kim, Xiaohui Yan, Laura M Castellano, Meredith E Jackrel, JiaBei Lin, Edward Chuang, Edward Gomes, Corey W Willicott, Karolina Michalska, Robert P Jedrzejczak, Andrzej Joachimiak, Kim A Caldwell, Guy A Caldwell, Ophir Shalem, James Shorter. Therapeutic genetic variation revealed in diverse Hsp104 homologs. Elife. 2020 Dec 15
PMID: 33319748

Matthew G Thompson, Mark Dittmar, Michael J Mallory, Prasanna Bhat, Max B Ferretti, Beatriz Ma Fontoura, Sara Cherry, Kristen W Lynch. Viral-induced alternative splicing of host genes promotes influenza replication. Elife. 2020 Dec 3
PMID: 33269701

Buyan Pan, Joo Hyung Park, Trudy Ramlall, David Eliezer, Elizabeth Rhoades, E James Petersson. Chemoenzymatic Semi-synthesis Enables Efficient Production of Isotopically-Labelled α-Synuclein with Site-specific Tyrosine Phosphorylation. Chembiochem. 2020 Dec 3
PMID: 33274519

Congcong Lu, Mariel Coradin, Elizabeth G. Porter, Benjamin A. Garcia. Accelerating the field of epigenetic histone modification through mass spectrometry-based approaches. Mol Cell Proteomics. 2020 Nov 17
PMID: 33203747

Jimin Yoon, John J. Ferrie, E. James Petersson. Improved Modeling of Thioamide FRET Quenching by Including Conformational Restriction and Coulomb Coupling. J Phys Chem B. 2020 Nov 25; 124(47)
PMID: 33196192

Hui Shen, Julian Stoute, Kathy Fange Liu. Structural and Catalytic Roles of the Human 18S rRNA Methyltransferases DIMT1 in Ribosome Assembly and Translation. J Biol Chem. 2020 Jul 2
PMID: 32616653

Ryan R Cupo, James Shorter. Skd3 (human CLPB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations. eLife. 2020 June 23
PMID: 32573439

Caleb M Radens, Davia Blake, Paul Jewell, Yoseph Barash and Kristen W Lynch. Meta-Analysis of Transcriptomic Variation in T cell Populations Reveals both Variable and Consistent Signatures of Gene Expression and Splicing. RNA. 2020 June 17
PMID: 32554554

Austin Zimmet, Trevor Van Eeuwen, Malgorzata Boczkowska, Grzegorz Rebowski, Kenji Murakami, Roberto Dominguez. Cryo-EM Structure of NPF-bound Human Arp2/3 Complex and Activation Mechanism. Sci Adv. 2020 June 5;6(23)
PMID:32548263

R Jordan Ontiveros, Hui Shen, Julian Stoute, Amber Yanas, Yixiao Cui, Yuyu Zhang, Kathy Fange Liu. Coordination of mRNA and tRNA Methylations by TRMT10A. Proc Natl Acad Sci USA. 2020 April 7;117(14)
PMID: 32213595

Mallory MJ, McClory SP, Chatrikhi R, Gazzara MR, Ontiveros RJ, Lynch KW. Reciprocal regulation of hnRNP C and CELF2 through translation and transcription tunes splicing activity in T cells. Nucleic Acids Res. 2020 April 27
PMID: 32338744

Ye X, Lin J, Mayne L, Shorter J, Englander SW. Structural and kinetic basis for the regulation and potentiation of Hsp104 function. PNAS. 2020 April 10
PMID: 32277033

Ghanty U, Wang T, Kohli RM. Nucleobase Modifiers Identify TET Enzymes as Bifunctional DNA Dioxygenases Capable of Direct N-Demethylation. Angew Chem Int Ed Engl. 2020 April 9
PMID: 32271979

Zandarashvili L, Langelier MF, Velagapudi UK, Hancock MA, Steffen JD, Billur R, Hannan ZM, Wicks AJ, Krastev DB, Pettitt SJ, Lord CJ, Talele TT, Pascal JM, Black BE. Structural basis for allosteric PARP-1 retention on DNA breaks. Science. 2020 April 3;368(6486)
PMID: 32241924

Wein S, Andrews B, Sachsenberg T, Santos-Rosa H, Kohlbacher O, Kouzarides T, Garcia BA, Weisser H. A computational platform for high-throughput analysis of RNA sequences and modifications by mass spectrometry. Nat Commun. 2020 Feb 17;11(1):926.
PMID: 32066737

Deng S, McTiernan N, Wei X, Arnesen T, Marmorstein R. Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK. Nat Commun. 2020 Feb 10;11(1):818.
PMID: 32042062

Sweeny EA, Tariq A, Gurpinar E, Go MS, Sochor MA, Kan ZY, Mayne L, Englander SW, Shorter J. Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting. J Biol Chem. 2020 Feb 7;295(6):1517-1538.
PMID: 31882541

Plunkett S, El Khatib M, Şencan İ, Porter JE, Kumar ATN, Collins JE, SakadŽić S, Vinogradov SA. In vivo deep-tissue microscopy with UCNP/Janus-dendrimers as imaging probes: resolution at depth and feasibility of ratiometric sensing. Nanoscale. 2020 Jan 28;12(4):2657-2672.
PMID: 31939953

Pumroy RA, Fluck EC 3rd, Ahmed T, Moiseenkova-Bell VY. Structural insights into the gating mechanisms of TRPV channels. Cell Calcium. 2020 Jan 24;87:102168.
PMID: 32004816

Oh JM, Venters CC, Di C, Pinto AM, Wan L, Younis I, Cai Z, Arai C, So BR, Duan J, Dreyfuss G. U1 snRNP regulates cancer cell migration and invasion in vitro. Nat Commun. 2020 Jan 7;11(1):1.
PMID: 31911652

Wei X, Schultz K, Bazilevsky GA, Vogt A, Marmorstein R. Molecular basis for acetyl-CoA production by ATP-citrate lyase. Nat Struct Mol Biol. 2020 Jan;27(1):33-41.
PMID: 31873304

Niaki AG, Sarkar J, Cai X, Rhine K, Vidaurre V, Guy B, Hurst M, Lee JC, Koh HR, Guo L, Fare CM, Shorter J, Myong S. Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations. Mol Cell. 2020 Jan 2;77(1):82-94.
PMID: 31630970


2019

Agosto LM, Gazzara MR, Radens CM, Sidoli S, Baeza J, Garcia BA, Lynch KW. Alcohol metabolism contributes to brain histone acetylation. Genome Res. 2019 Dec;29(12):2046-2055.
PMID: 31727681

Fujiwara R, Damodaren N, Wilusz JE, Murakami K. The capping enzyme facilitates promoter escape and assembly of a follow-on preinitiation complex for reinitiation. Proc Natl Acad Sci USA. 2019 Nov 5;116(45):22573-22582.
PMID: 31591205

Mews P, Egervari G, Nativio R, Sidoli S, Donahue G, Lombroso SI, Alexander DC, Riesche SL, Heller EA, Nestler EJ, Garcia BA, Berger SL. Alcohol metabolism contributes to brain histone acetylation. Nature. 2019 Oct;574(7780):717-721.
PMID: 31645761

Pumroy RA, Samanta A, Liu Y, Hughes TE, Zhao S, Yudin Y, Rohacs T, Han S, Moiseenkova-Bell VY. Molecular mechanism of TRPV2 channel modulation by cannabidiol. Elife. 2019 Sep 30;8.
PMID: 31566564

Sidoli S, Lopes M, Lund PJ, Goldman N, Fasolino M, Coradin M, Kulej K, Bhanu NV, Vahedi G, Garcia BA. A mass spectrometry-based assay using metabolic labeling to rapidly monitor chromatin accessibility of modified histone proteins. Sci Rep. 2019 Sep 20;9(1):13613.
PMID: 31541121

Tatomer DC, Elrod ND, Liang D, Xiao MS, Jiang JZ, Jonathan M, Huang KL, Wagner EJ, Cherry S, Wilusz JE. The Integrator complex cleaves nascent mRNAs to attenuate transcription. Genes Dev. 2019 Nov 1;33(21-22):1525-1538.
PMID: 31530651

So BR, Di C, Cai Z, Venters CC, Guo J, Oh JM, Arai C, Dreyfuss G. A Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells. Mol Cell. 2019 Nov 21;76(4):590-599.
PMID: 31522989

Chatrikhi R, Mallory MJ, Gazzara MR, Agosto LM, Zhu WS, Litterman AJ, Ansel KM, Lynch KW. RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery. Cell Rep. 2019 Sep 10;28(11)2795-2806.
PMID: 31509743

Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, Stillman J, Rizo AN, Southworth DR, Shorter J. Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity. Cell Rep. 2019 Aug20;28(8):2080-2095.
PMID: 31433984

Wojcik JB, Marchione DM, Sidoli S, Djedid A, Lisby A, Majewski J, Garcia BA. Epigenomic Reordering Induced by Polycomb Loss Drives Oncogenesis but Leads to Therapeutic Vulnerabilities in Malignant Peripheral Nerve Sheath Tumors. Cancer Res. 2019 Jul1;79(13):3205-3219.
PMID: 30898839

Xiao MS, Wilusz JE. An improved method for circular RNA purification using RNase R that efficiently removes linear RNAs containing G-quadruplexes or structured 3' ends. Nucleic Acids Res. 2019 Sep 19;47(16):8755-8769.
PMID: 31269210

Allu PK, Dawicki-McKenna JM, Van Eeuwen T, Slavin M, Braitbard M, Xu C, Kalisman N, Murakami K, Black BE. Structure of the Human Core Centromeric Nucleosome Complex. Curr Biol. 2019 Aug 19;29(16):2625-2639.
PMID: 31353180

Logsdon GA, Gambogi CW, Liskovykh MA, Barrey EJ, Larionov V, Miga KH, Heun P, Black BE. Human Artificial Chromosomes that Bypass Centromeric DNA. Cell. 2019 Jul 25;178(3):624-639.
PMID: 31348889

Li B, Esipova TV, Sencan I, Kılıç K, Fu B, Desjardins M, Moeini M, Kura S, Yaseen MA, Lesage F, Østergaard L, Devor A, Boas DA, Vinogradov SA, Sakadžić S. More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction. Elife. 2019 Jul 15;8.
PMID: 31305237

Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC. Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Proc Natl Acad Sci USA. 2019 Aug 6;116(32):16028-16035.
PMID: 31253706

Kearse MG, Goldman DH, Choi J, Nwaezeapu C, Liang D, Green KM, Goldstrohm AC, Todd PK, Green R, Wilusz JE. Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors. Genes Dev. 2019 July 1;33(13-14):871-885.
PMID: 31171704

Bialas C, Barnard DT, Auman DB, McBride RA, Jarocha LE, Hore PJ, Dutton PL, Stanley RJ, Moser CC. Ultrafast flavin/tryptophan radical pair kinetics in a magnetically sensitive artificial protein. Phys Chem Chem Phys. 2019 June 26;33(13-14):13453-13461.
PMID: 31187821

Ricketts MD, Dasgupta N, Fan J, Han J, Gerace M, Tang Y, Black BE, Adams PD, Marmorstein R. The HIRA histone chaperone complex subunit UBN1 harbors H3/H4- and DNA-binding activity. J Biol Chem. 2019 June 7;294(23):9239-9259.
PMID: 31040182

Bhanu NV, Sidoli S, Yuan Z-F, Molden RC, Garcia BA. Regulation of proline-directed kinases and the trans-histone code H3K9me3/H4K20me3 during human myogenesis. J Biol Chem. 2019 May 17;294(20):8296-8308.
PMID: 30872405

Bazilevsky GA, Affronti HC, Wei X, Campbell SL, Wellen KE, Marmorstein R. ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis. J Biol Chem. 2019 May 3;294(18):7259-7268.
PMID: 30877197

Ye X, Lin J, Mayne L, Shorter J, Englander SW. Hydrogen exchange reveals Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution. Proc Natl Acad Sci USA. 2019 Apr 9;116(15):7333-7342.
PMID: 30918129

Esipova TV, Barrett MJP, Erleback E, Masunov AE, Weber B, Vinogradov SA. Oxyphor 2P: A High-Performance Probe for Deep-Tissue Longitudinal Oxygen Imaging. Cell Metab. 2019 Mar 5;29(3):736-744.
PMID: 30686745

Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tan R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L. Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Science. 2019 Feb 15;363(6428).
PMID: 30765536

Lu C, Sidoli S, Kulej K, Ross K, Wu CH, Garcia BA. Coordination between TGF-ß cellular signaling and epigenetic regulation during epithelial to mesenchymal transition. Epigenetics Chromatin. 2019 Feb 8;12(1):11.
PMID: 30736855

Barra V, Logsdon GA, Shelf A, Hoffmann S, Herve S, Aslanian A, Nechemia-Arbely Y, Cleveland DW, Black BE, Fachinetti D. Phosphorylation of CENP-A on serine 7 does not control centromere function. Nat Commun. 2019 Jan 11;10(1):175.
PMID: 30635586


2018

Karch KR, Coradin M, Zandarashvili Li, Kan ZY, Gerace M, Englander SW, Black BE, Garcia BA. Hydrogen-Deuterium Exchange Coupled to Top- and Middle-Down Mass Spectrometry Reveals Histone Tail Dynamics before and after Nucleosome Assembly. Structure. 2018 Dec 4;26(12):1651-1663.
PMID: 30293810

Zasadzinska E, Huang J, Bailey AO, Guo LY, Lee NS, Srivastava S, Wong KA, French BT, Black BE, Foltz DR. Inheritance of CENP-A Nucleosomes during DNA Replication Requires HJURP. Dev Cell. 2018 Nov 5;47(3):348-362.
PMID: 30293838

Hughes TET, Pumroy RA, Yazici AT, Kasimova MA, Fluck EC, Huynh KW, Samanta A, Molugu SK, Zhou ZH, Carnevale V, Rohacs T, Moiseenkova-Bell VY. Structural insights on TRPV5 gating by endogenous modulators. Nat Commun. 2018 Oct 10;9(1):4198.
PMID: 30305626

Schutsky EK, DeNizio JE, Hu P, Liu MY, Nabel CS, Fabyanic EB, Hwang Y, Bushman FD, Wu H, Kohli RM. Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using DNA deaminase. Nat Biotechnol. 2018 Oct 8.
PMID: 30295673

Schutsky EK, DeNizio JE, Hu P, Liu MY, Nabel CS, Fabyanic EB, Hwang Y, Bushman FD, Wu H, Kohli RM. Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase. Nat Biotechnol. 2018 Oct 8 [Epub ahead of print]
PMID: 30295673

Zasadzinska E, Huang J, Bailey AO, Guo LY, Lee NS, Srivastava S, Wong KA, French BT, Black BE, Foltz DR. Inheritance of CENP-A Nucleosomes during DNA Replication Requires HJURP. Dev Cell. 2018 Oct 3 [Epub ahead of print]
PMID: 30293838

Li, H, Sharp, R, Rutherford, K, Gupta, K, Van Duyne, GD. Serine Integrase attP Binding and Specificity. J Mol Biol. 2018 Sep 15 [Epub ahead of print]
PMID 30227134

Shields EJ, Sheng L, Weiner AK, Garcia BA, Bonasio R. High-Quality Genome Assemblies Reveal Long Non-coding RNAs Expressed in Ant Brains. Cell Rep. 2018 June 5;23(10):3078-3090.
PMID 29874592

Huang C, Liang D, Tatomer DC, Wilusz JE. A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs. Genes Dev. 2018 May 17.
PMID 29773557

Goris M, Magin RS, Foyn H, Myklebust LM, Varland S, Ree R, Drazic A, Bhambra P, Støve SI, Baumann M, Haug BE, Marmorstein R, Arnesen T. Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. Proc Natl Acad Sci USA. 2018 Apr 24;115(17):4405-4410.
PMID: 29581307

Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 2018 Apr 19;173(3):677-692.
PMID: 29677512

Friedman ES, Bittinger K, Esipova TV, Hou L, Chau L, Jiang J, Mesaros C, Lund PJ, Liang X, FitzGerald GA, Goulian M, Lee D, Garcia BA, Blair IA, Vinogradov SA, Wu GD. Microbes vs. chemistry in the origin of the anaerobic gut lumen. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4170-4175.
PMID: 29610310

Wilson DF, Cember ATJ, Matschinsky FM. Glutamate dehydrogenase: Role in regulating metabolism and insulin release in pancreatic β-cells. J Appl Physiol(1985). 2018 Apr 12. [Epub ahead of print] 
PMID: 29648519

Mancini JA, Sheehan M, Kodali G, Chow BY, Bryant DA, Dutton PL, Moser CC. De novo synthetic biliprotein design, assembly and excitation energy transfer. J R Soc Interface. 2018 Apr;15(141). 
PMID: 29618529

Han J, Lachance C, Ricketts MD, McCullough CE, Gerace M, Black BE, Côté J, Marmorstein R. The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate. J Biol Chem. 2018 Mar 23;293(12):4498-4509. 
PMID: 29382722

Langelier MF, Zandarashvili L, Aguiar PM, Black BE, Pascal JM. NAD(+) analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains. Nat Commun. 2018 Feb 27;9(1):844.
PMID: 29487285

Ye X, Mayne L, Kan ZY, Englander SW. Folding of maltose binding protein outside of and in GroEL. Proc Natl Acad Sci USA. 2018 Jan 16;115(3):519-524.
PMID: 29295923

 

2017

Becker JS, McCarthy RL, Sidoli S, Donahue G, Kaeding KE, He Z, Lin S, Garcia BA, Zaret KS. Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes. Mol Cell. 2017 Dec 21;68(6):1023-1037.
PMID: 29272703

Damodaren N, Van Eeuwen T, Zamel J, Lin-Shiao E, Kalisman N, Murakami K. Def1 interacts with TFIIH and modulates RNA polymerase II transcription. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13230-13235.
PMID: 29180430

Liang D, Tatomer DC, Luo Z, Wu H, Yang L, Chen LL, Cherry S, Wilusz JE. The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting. Mol Cell. 2017 Dec 7;68(5):940-954.
PMID: 29174924

Oh JM, Di C, Venters CC, Guo J, Arai C, So BR, Pinto AM, Zhang Z, Wan L, Younis I, Dreyfuss G. U1 snRNP telescripting regulates a size-function-stratified human genome. Nat Struct Mol Biol. 2017 Nov;24(11):993-999.
PMID: 28967884

Simithy J, Sidoli S, Yuan ZF, Coradin M, Bhanu NV, Marchione DM, Klein BJ, Bazilevsky GA, McCullough CE, Magin RS, Kutateladze TG, Snyder NW, Marmorstein R, Garcia BA. Characterization of histone acylations links chromatin modifications with metabolism. Nat Commun. 2017 Oct 26;8(1):1141.
PMID: 29070843

Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL. Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. 2017 Oct 19;550(7676):402-406.
PMID: 28976970

Doliba NM, Liu Q, Li C, Chen P, Liu C, Naji A, Matschinsky FM. Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor. Mol Metab. 2017 Oct;6(10):1240-1253.
PMID: 29031723

Armour SM, Remsberg JR, Damle M, Sidoli S, Ho WY, Li Z, Garcia BA, Lazar MA. An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides. Nat Commun. 2017 Sep 15;8(1):549. 
PMID: 28916805

Iwata-Otsubo A, Dawicki-McKenna JM, Akera T, Falk SJ, Chmátal L, Yang K, Sullivan BA, Schultz RM, Lampson MA, Black BE. Expanded Satellite Repeats Amplify a Discrete CENP-A Nucleosome Assembly Site on Chromosomes that Drive in Female Meiosis. Curr Biol. 2017 Aug 7;27(15):2365-2373.
PMID: 28756949

Gazzara MR, Mallory MJ, Roytenberg R, Lindberg JP, Jha A, Lynch KW, Barash Y. Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes. Genome Res. 2017 Aug;27(8):1360-1370.
PMID: 28512194

Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 2017 Jul 21;357(6348):273-279.
PMID: 28619716

Gupta K, Sharp R, Yuan JB, Li H, Van Duyne GD. Coiled-coil interactions mediate serine integrase directionality. Nucleic Acids Res. 2017 Jul 7;45(12):7339-7353.
PMID: 28549184

Caro JA, Harpole KW, Kasinath V, Lim J, Granja J, Valentine KG, Sharp KA, Wand AJ. Entropy in molecular recognition by proteins. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6563-6568.
PMID: 28584100

Guo LY, Allu PK, Zandarashvili L, McKinley KL, Sekulic N, Dawicki-McKenna JM, Fachinetti D, Logsdon GA, Jamiolkowski RM, Cleveland DW, Cheeseman IM, Black BE. Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition. Nat Commun. 2017 Jun 9;8:15775.
PMID: 28598437

Wilson DF, Cember ATJ, Matschinsky FM. The thermodynamic basis of glucose-stimulated insulin release: a model of the core mechanism. Physiol Rep. 2017 Jun;5(12).
PMID: 28655753

Liu MY, Torabifard H, Crawford DJ, DeNizio JE, Cao XJ, Garcia BA, Cisneros GA, Kohli RM. Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine. Nat Chem Biol. 2017 Feb;13(2):181-187.
PMID: 27918559

Fachinetti D, Logsdon GA, Abdullah A, Selzer EB, Cleveland DW, Black BE. CENP-A Modifications on Ser68 and Lys124 Are Dispensable for Establishment, Maintenance, and Long-Term Function of Human Centromeres. Dev Cell. 2017 Jan 9;40(1):104-113.
PMID: 28073008

Kodali G, Mancini JA, Solomon LA, Episova TV, Roach N, Hobbs CJ, Wagner P, Mass OA, Aravindu K, Barnsley JE, Gordon KC, Officer DL, Dutton PL, Moser CC. Design and engineering of water-soluble light-harvesting protein maquettes. Chem Sci. 2017 Jan 1;8(1):316-324.
PMID: 28261441

 

2016

Grasso M, Estrada MA, Ventocilla C, Samanta M, Maksimoska J, Villanueva J, Winkler JD, Marmorstein R. Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation. ACS Chem Biol. 2016 Oct 21;11(10):2876-2888.
PMID: 27571413

He C, Sidoli S, Warneford-Thomson R, Tatomer DC, Wilusz JE, Garcia BA, Bonasio R. High-Resolution Mapping of RNA-Binding Regions in the Nuclear Proteome of Embryonic Stem Cells. Mol Cell. 2016 Oct 20;64(2):416-430.
PMID: 27768875

Yokom AL, Gates SN, Jackrel ME, Mack KL, Su M, Shorter J, Southworth DR. Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation. Nat Struct Mol Biol. 2016 Sep;23(9):830-7.
PMID: 27478928

Molleston JM, Sabin LR, Moy RH, Menghani SV, Rausch K, Gordesky-Gold B, Hopkins KC, Zhou R, Jensen TH, Wilusz JE, Cherry S. A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation. Genes Dev. 2016 Jul 15;30(14):1658-70.
PMID: 27474443

Lin S, Yuan ZF, Han Y, Marchione DM, Garcia BA. Preferential Phosphorylation on Old Histones during Early Mitosis in Human Cells. J Biol Chem. 2016 Jul 15;291(29):15342-57.
PMID: 27226594

Wang X, Yuan ZF, Fan J, Karch KR, Ball LE, Denu JM, Garcia BA. A Novel Quantitative Mass Spectrometry Platform for Determining Protein O-GlcNAcylation Dynamics. Mol Cell Proteomics. 2016 Jul;15(7):2462-75.
PMID: 27114449

Ajith S, Gazzara MR, Cole BS, Shankarling G, Martinez NM, Mallory MJ, Lynch KW. Position-dependent activity of CELF2 in the regulation of splicing and implications for signal-responsive regulation in T cells. RNA Biol. 2016 Jun 2;13(6):569-81.
PMID: 27096301

Laxmikanthan G, Xu C, Brilot AF, Warren D, Steele L, Seah N, Tong W, Grigorieff N, Landy A, Van Duyne GD. Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction. Elife. 2016 May  25;5.
PMID: 27223329

Smoak EM, Stein P, Schultz RM, Lampson MA, Black BE. Long-Term Retention of CENP-A Nucleosomes in Mammalian Oocytes Underpins Transgenerational Inheritance of Centromere Identity. Curr Biol. 2016 Apr 25;26(8):1110-6.
PMID: 27040782