About the High-throughput Screening Core

The High-throughput Screening Core (HTSC) in the Perelman School of Medicine provides expertise and infrastructure to facilitate the development and implementation of professional High-throughput screening services. We have the capabilities to perform HTS in both biochemical and cell-based assays using state-of-the-art equipment. We can perform genetic or small molecule screens to identify genes or small molecule modulators of diverse processes in diverse models including primary cells.  The HTSC educates and assists scientists with HTS assay development, optimization, miniaturization, implementation, analysis, and validation. We can develop new assays or run validated HTS assays. In addition, the HTSC maintains libraries of siRNA, shRNA, cDNA, and FDA-approved/FDA-like organic small molecule libraries for HTS.  Moreover, we routinely prepare custom libraries for single-point or dose-response screening. The HTSC provides robotics infrastructure and technically trained staff for primary HTSs as well as secondary screens to validate candidates. The HTSC also provides assistance with the preparation of grant applications and Letters of Support, offering HTS resources and analysis expertise for the proposed research.

 

 

 

Announcements

The HTSC has moved!

After 11 years in the John Morgan Building, the High-throughput Screening Core (HTSC) has relocated to a new state-of-the-art laboratory at 3600 Civic Center Boulevard. We’re thrilled about this next chapter and look forward to the exciting collaborations ahead!

Visiting the HTSC:
To reach the Core, please visit 3600 Civic Center Boulevard. Check in with building security upon entering, then take the elevator to the 17th floor. Exit the elevator into the office suite, turn left, and continue to the end of the hallway. The HTSC (Room 17-200) will be on your left.

 
The UPenn High-throughput Screening Core and High-throughput Institute for Discovery (HIT-ID) presents the

Early-Stage Drug Discovery and High-throughput Screening using New Technologies Symposium

 

The High-Throughput Screening Core and the High-Throughput Institute for Discovery (HIT-ID) are pleased to host the Early-Stage Drug Discovery and High-Throughput Screening Using New Technologies Symposium on Thursday, September 17, from 9:00 AM to 3:30 PM in the KRB (formerly BRB) Gaulton Auditorium. The symposium will bring together investigators who are leveraging high-throughput screening, innovative technologies, and translational research approaches to advance early-stage drug discovery. Attendees will hear from researchers sharing their scientific discoveries, technological innovations, and experiences utilizing high-throughput resources to accelerate biomedical research. In addition to faculty and investigator presentations, the afternoon program will feature talks from industry partners and technology vendors highlighting emerging platforms, tools, and advances in high-throughput screening and drug discovery technologies. The event will provide valuable opportunities for networking, collaboration, and discussion among faculty, trainees, core facility users, and industry representatives interested in the future of drug discovery and screening innovation.

 

 

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