Publications
2025
Lee JS, Dittmar M, Miller J, Li M, Ayyanathan K, Ferretti M, Hulahan J, Whig K, Etwebi Z, Griesman T, Schultz DC, Cherry S. Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution. Cell Rep. 2024 Dec 20;44(1):115115. doi: 10.1016/j.celrep.2024.115115. Epub ahead of print. PMID: 39708319.
2024
Hao X, Zhao B, Towers M, Liao L, Monteiro EL, Xu X, Freeman C, Peng H, Tang HY, Havas A, Kossenkov AV, Berger SL, Adams P, Speicher DW, Schultz D, Marmorstein R, Zaret KS, Zhang R. TXNRD1 drives innate immune response in senescent cells with implications in age-associated inflammation. Nat Aging. 2024 Feb;4(2):185-197. doi: 10.1038/s43587-023-00564-1. Epub 2024 Jan 24. PMID: 38267705
Riscal R, Gardner SM, Coffey NJ, Carens M, Mesaros C, Xu JP, Xue Y, Davis L, Demczyszyn S, Vogt A, Olia A, Finan JM, Godfrey J, Schultz DC, Blair IA, Keith B, Marmorstein R, Skuli N, Simon MC. Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma. Cancer Res. 2024 May 15;84(10):1570-1582. doi: 10.1158/0008-5472.CAN-23-0821.PMID: 38417134
Chauvin SD, Ando S, Holley JA, Sugie A, Poddar S; Kato R; Miner CA, Nitta Y, Krishnamurthy SR, Zhao FR; Saito R, Ning Y, Hatano Y, Campbell EA, Kitahara S, Koide S; Kumble L, Polishchuk O, Andhey PS, Chiang C, Liu G, Manel N, Kakita A, Artyomov M, Schultz DC, Coates PT, Roberson EDO, Belkaid Y, Greenberg RA, Cherry S, Gack MU, Hardy T, Onodera O, Kato T, Miner J. Aberrant nuclear activity of TREX1 causes DNA damage and risk of breast cancer. Nature Communications. 2024 Jun 1;15(1):4696. doi: 10.1038/s41467-024-49066-7.PMID: 38824133
Griesman T, McMillen CM, Whig K, Negatu S, Dohnalová L, Dittmar, Thaiss CA, Jurado KA, Schultz DC, Hartman AL, Cherry S. The lipopeptide Pam3CSK4 inhibits bunyavirus infection of neurons and protects from encephalitis. PLoS Pathog. 2024 Jun 27;20(6):e1012343. doi: 10.1371/journal.ppat.1012343. eCollection 2024 Jun. PMID: 38935789
Vogt A, Szurgot M, Schultz DC, Gardner L, and Marmorstein R. HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone DNA binding. Journal of Biological Chemistry. 2024 Jul 24;300(9):107604. doi: 10.1016/j.jbc.2024.107604. Online ahead of print.PMID: 39059488
Dasgupta N, Lei X, Arnold R, Teneche MG, Miller KN, Rajesh A, Davis A, Anschau V, Campos AR, Gilson R, Havas A, Yin S, Chua ZM, Proulx J, Alcaraz M, Rather MI, Baeza J, Schultz DC, Berger SL, and Adams PD. Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence. Mol Cell. 2024 Sep 5;84(17):3271-3287.e8. doi: 10.1016/j.molcel.2024.08.006. Epub 2024 Aug 22. PMID: 39178863 (bioRxiv. 2024 Jun 25:2023.06.24.546372. doi: 10.1101/2023.06.24.546372.)
Quesnel-Vallières M, Schultz DC, Orlenko A, Lo Y, Moore J, Ritchie M, Roth D, Carroll M, Barash Y, Lynch KW, Cherry S. Trametinib Sensitivity is Defined by a Myeloid Differentiation Profile in Acute Myeloid Leukemia. Drugs R D. 2024 Sep;24(3):489-499. doi: 10.1007/s40268-024-00491-5. Epub 2024 Sep 24. PMID: 39316279
Zhou NE, Tang S, Bian X, Parai MK, Krieger IV, Flores A, Jaiswal PK, Bam R, Wood JL, Shi Z, Stevens LJ, Scobey T, Diefenbacher MV, Moreira FR, Baric TJ, Acharya A, Shin J, Rathi MM, Wolff KC, Riva L, Bakowski MA, McNamara CW, Catanzaro NJ, Graham RL, Schultz DC, Cherry S, Kawaoka Y, Halfmann PJ, Baric RS, Denison MR, Sheahan TP, Sacchettini JC. An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo. Cell Rep. 2024 Nov 26;43(11):114929. doi: 10.1016/j.celrep.2024.114929. Epub 2024 Nov 5. PMID: 39504242.
2023
Sen P, Donahue G, Li C, Lan Y, Egervari G, Robertson N, Shah PP, Kerkhoven E, Schultz DC, Adams PD, Berger SL. Spurious intragenic transcription is a hallmark of mammalian cellular senescence and tissue aging. Nature Aging 2023 Apr;3(4):402-417. doi: 10.1038/s43587-023-00384-3. Epub 2023 Mar 30. PMID: 37117791 bioRxiv/2022/492816
Li M, Ayyanathan K, Dittmar M, Miller J, Tapescu I, Lee JS, McGrath ME, Xue Y, Vashee S, Schultz DC, Frieman MB, Cherry S. SARS-CoV-2 ORF6 protein does not antagonize interferon signaling in respiratory epithelial Calu-3 cells during infection. mBio. 2023 Jun 28:e0119423. doi: 10.1128/mbio.01194-23. Online ahead of print. PMID: 37377442
Dittmar M, Whig K, Miller J, Kamalia B, Suppiah S, Perelygina L, Sullivan K, Schultz DC, Cherry S. Nucleoside analogs NM107 and AT-527 are active against rubella virus infection. PNAS Nexus 2023 Aug 3;2(9):pgad256. doi: 10.1093/pnasnexus/pgad256. eCollection 2023 Sep.PMID: 37674858
Tapescu I, Taschuk F, Pokharel SM, Zginnyk O, Ferretti M, Bailer PF, Whig K, Madden EA, Heise MT, Schultz DC, Cherry S. The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection. Mol Cell. 2023 Nov 16; 83(22):4174-4189.e7. doi: 10.1016/j.molcel.2023.10.008. Epub 2023 Nov 9. PMID: 37949067
2022
Schultz DC, Johnson RM, Ayyanathan K, Miller J, Whig K, Kamalia B, Dittmar M, Weston S, Hammond HL, Dillen C, Ardanuy J, Taylor L, Lee JS, Li M, Lee E, Shoffler C, Petucci C, Constant S, Ferrer M, Thaiss CA, Frieman MB, Cherry S. Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2. Nature. 2022 Apr;604(7904):134-140. doi: 10.1038/s41586-022-04482-x. Epub 2022 Feb 7. PMID: 35130559 (bioRxiv. 2021 Jun 24:2021.06.24.449811. doi: 10.1101/2021.06.24.449811. Preprint. PMID: 34189531)
Lee YG, Guruprasad P, Ghilardi G, Pajarillo R, Sauter CT, Patel R, Ballard HJ, Hong SJ, Chun I, Yang N, Amelsberg KV, Cummins KD, Svoboda J, Gill S, Chong EA, North K, Church SE, Fraietta JA, Chang WJ, Lacey SF, Lu XM, Zhang Y, Whig K, Schultz DC, Cherry S, Gerson J, Schuster SJ, Porazzi P, Ruella M. Modulation of BCL-2 in both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T cell Immunotherapy against Cancer. Cancer Discov. 2022 Jul 29:CD-21-1026. doi: 10.1158/2159-8290.CD-21-1026. Online ahead of print. PMID: 35904479
Zarkoob H, Allué-Guardia A, Chen YC, Garcia-Vilanova A, Jung O, Coon S, Song MJ, Park JG, Oladunni F, Miller J, Tung YT, Kosik I, Schultz D, Iben J, Li T, Fu J, Porter FD, Yewdell J, Martinez-Sobrido L, Cherry S, Torrelles JB, Ferrer M, Lee EM. Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents. Commun Biol. 2022 Aug 12;5(1):810. doi: 10.1038/s42003-022-03753-7.PMID: 35962146
Basavappa MG, Ferretti M, Dittmar M, Stoute J, Sullivan MC, Whig K, Shen H, Liu KF, Schultz DC, Beiting DP, Lynch KW, Henao-Mejia J, Cherry S. The lncRNA ALPHA specifically targets chikungunya virus to control infection. Mol Cell. 2022 Sep 14:S1097-2765(22)00850-4. doi: 10.1016/j.molcel.2022.08.030. PMID: 36167073
Maio N, Cherry S, Schultz DC, Hurst BL, Linehan WM, Rouault TA. TEMPOL inhibits SARS-CoV-2 replication and development of lung disease in the Syrian hamster model. iScience. 2022 Oct 21;25(10):105074. doi: 10.1016/j.isci.2022.105074. Epub 2022 Sep 6. PMID: 36093377
2021
Dittmar M, Lee JS, Whig K, Segrist E, Li M, Kamalia B, Castellana L, Ayyanathan K, Cardenas-Diaz FL, Morrisey EE, Truitt R, Yang W, Jurado K, Samby K, Ramage H, Schultz DC, Cherry S. Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2. Cell Rep. 2021 Apr 6;35(1):108959. doi: 10.1016/j.celrep.2021.108959. Epub 2021 Mar 23. PMID: 33811811
Kitamura N, Sacco MD, Ma C, Hu Y, Townsend JA, Meng X, Zhang F, Zhang X, Ba M, Szeto T, Kukuljac A, Marty MT, Schultz D, Cherry S, Xiang Y, Chen Y, Wang J. Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors. J Med Chem. 2021 Apr 23;. doi: 10.1021/acs.jmedchem.1c00509. [Epub ahead of print] PubMed PMID: 33891389.
Zarkoob H, Allué-Guardia A, Chen YC, Jung O, Garcia-Vilanova A, Song MJ, Park JG, Oladunni F, Miller J, Tung YT, Kosik I, Schultz D, Yewdell J, Torrelles JB, Martinez-Sobrido L, Cherry S, Ferrer M, Lee EM. Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents. bioRxiv. 2021 May 12;. doi: 10.1101/2021.05.11.443693. PubMed PMID: 34013274; PubMed Central PMCID: PMC8132232.
Abbey D, Conlon D, Rainville C, Elwyn S, Quiroz-Figueroa K, Billheimer J, Schultz DC, Hand NJ, Cherry S, Radar DJ. Lipid Droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism. Clin Transl Sci. Clin Transl Sci. 2021 Jun 22;. doi: 10.1111/cts.12988. [Epub ahead of print] PubMed PMID: 34156146.
Li M, Ferretti M, Ying B, Descamps H, Lee E, Dittmar M, Lee JS, Whig K, Kamalia B, Dohnalová L, Uhr G, Zarkoob H, Chen YC, Ramage H, Ferrer M, Lynch K, Schultz DC, Thaiss CA, Diamond MS, Cherry S. Pharmacological activation of STING blocks SARS-CoV-2 infection. Sci Immunol. 2021 May 18;6(59):eabi9007. doi: 10.1126/sciimmunol.abi9007.PMID: 34010142
Liu X, Verma A, Garcia G, Ramage H, Myers RL, Lucas A, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition. Proc Natl Acad Sci. 2021 Oct 19;118(42):e2113401118. doi: 10.1073/pnas.2113401118. Epub 2021 Sep 30. PMID: 34593624 (medRxiv. 2021 Jul 21:2021.02.17.21251933. doi: 10.1101/2021.02.17.21251933. Preprint. PMID: 33655282)
2020
Loro E, Sengupta K, Bogdanovich S, Whig K, Schultz DC, Huryn DM, Khurana TS. High-throughput Identification of Post-Transcriptional Utrophin Up-Regulators for Duchenne Muscle Dystrophy (DMD) Therapy. Sci Rep 2020 10 (1), 4039. PMID 32111917.
Guo J, Chaney KE, Choi K, Witek G, Patel AV, Xie H, Lin D, Whig K, Xiong Y, Schultz DC, Ratner N, Field J. Polo-like kinase 1 as a therapeutic target for malignant peripheral nerve sheath tumors (MPNST) and schwannomas. Am J Cancer Res. 2020 Mar 1;10(3):856-869. eCollection 2020.PMID: 32266095
Xu Y, Liu R, Leu NA, Zhang L, Ibragmova I, Schultz DC, Wang PJ. A cell-based high-content screen identifies isocotoin as a small molecule inhibitor of the meiosis-specific MEIOB-SPATA22 complex. Biol Reprod. 2020 Aug 4;103(2):333-342. PMID: 32463099
2019
Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell. 2019 Feb 21;73(4):684-698.e8. doi: 10.1016/j.molcel.2019.01.021. Epub 2019 Feb 14.PMID: 30773298
Hackett BA, Dittmar M, Segrist E, Pittenger N, To J, Griesman T, Gordesky-Gold B, Schultz DC, Cherry S. Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses. MBio. 2019 Jul 9;10(4). pii: e01446-19. doi: 10.1128/mBio.01446-19. PMID: 31289184
Rivera OD, Mallory MJ, Quesnel-Vallières M, Chatrikhi R, Schultz DC, Carroll M, Barash Y, Cherry S, Lynch KW. Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2014967118. doi: 10.1073/pnas.2014967118.PMID: 33876749
2017
Guo J, Grovola MR, Xie H, Coggins G, Duggan P, Hasan R, Huang J, Lin D, Song D, Witek G, Berritt S, Schultz DC, Field J. Comprehensive pharmacological profiling of neurofibromatosis cell lines. Am J Cancer Res. 2017 Apr 1;7(4):923-934. eCollection 2017.PMID:28469964
2016
Rausch K, Hackett BA, Weinbren NL, Reeder SM, Sadovsky Y, Hunter CA, Schultz DC, Coyne CB, Cherry S. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815. doi: 10.1016/j.celrep.2016.12.068. PMID: 28099856