Publications

2023

Sen P, Donahue G, Li C, Lan Y, Egervari G, Robertson N, Shah PP, Kerkhoven E, Schultz DC, Adams PD, Berger SL. Spurious intragenic transcription is a hallmark of mammalian cellular senescence and tissue aging. Nature Aging 2023 Apr;3(4):402-417. doi: 10.1038/s43587-023-00384-3. Epub 2023 Mar 30. PMID: 37117791 bioRxiv/2022/492816

Li M, Ayyanathan K, Dittmar M, Miller J, Tapescu I, Lee JS, McGrath ME, Xue Y, Vashee S, Schultz DC, Frieman MB, Cherry S. SARS-CoV-2 ORF6 protein does not antagonize interferon signaling in respiratory epithelial Calu-3 cells during infection. mBio. 2023 Jun 28:e0119423. doi: 10.1128/mbio.01194-23. Online ahead of print. PMID: 37377442

Nucleoside analogs NM107 and AT-527 are active against rubella virus infection. Dittmar M, Whig K, Miller J, Kamalia B, Suppiah S, Perelygina L, Sullivan K, Schultz DC, Cherry S. PNAS Nexus (in press)

2022

Schultz DC, Johnson RM, Ayyanathan K, Miller J, Whig K, Kamalia B, Dittmar M, Weston S, Hammond HL, Dillen C, Ardanuy J, Taylor L, Lee JS, Li M, Lee E, Shoffler C, Petucci C, Constant S, Ferrer M, Thaiss CA, Frieman MB, Cherry S. Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2.  Nature. 2022 Apr;604(7904):134-140. doi: 10.1038/s41586-022-04482-x. Epub 2022 Feb 7. PMID: 35130559 (bioRxiv. 2021 Jun 24:2021.06.24.449811. doi: 10.1101/2021.06.24.449811. Preprint. PMID: 34189531)

Lee YG, Guruprasad P, Ghilardi G, Pajarillo R, Sauter CT, Patel R, Ballard HJ, Hong SJ, Chun I, Yang N, Amelsberg KV, Cummins KD, Svoboda J, Gill S, Chong EA, North K, Church SE, Fraietta JA, Chang WJ, Lacey SF, Lu XM, Zhang Y, Whig K, Schultz DC, Cherry S, Gerson J, Schuster SJ, Porazzi P, Ruella M. Modulation of BCL-2 in both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T cell Immunotherapy against Cancer. Cancer Discov. 2022 Jul 29:CD-21-1026. doi: 10.1158/2159-8290.CD-21-1026. Online ahead of print. PMID: 35904479

Zarkoob H, Allué-Guardia A, Chen YC, Garcia-Vilanova A, Jung O, Coon S, Song MJ, Park JG, Oladunni F, Miller J, Tung YT, Kosik I, Schultz D, Iben J, Li T, Fu J, Porter FD, Yewdell J, Martinez-Sobrido L, Cherry S, Torrelles JB, Ferrer M, Lee EM. Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents. Commun Biol. 2022 Aug 12;5(1):810. doi: 10.1038/s42003-022-03753-7.PMID: 35962146

Basavappa MG, Ferretti M, Dittmar M, Stoute J, Sullivan MC, Whig K, Shen H, Liu KF, Schultz DC, Beiting DP, Lynch KW, Henao-Mejia J, Cherry S. The lncRNA ALPHA specifically targets chikungunya virus to control infection. Mol Cell. 2022 Sep 14:S1097-2765(22)00850-4. doi: 10.1016/j.molcel.2022.08.030. PMID: 36167073

Maio N, Cherry S, Schultz DC, Hurst BL, Linehan WM, Rouault TA. TEMPOL inhibits SARS-CoV-2 replication and development of lung disease in the Syrian hamster model. iScience. 2022 Oct 21;25(10):105074. doi: 10.1016/j.isci.2022.105074. Epub 2022 Sep 6. PMID: 36093377

2021

Dittmar M, Lee JS, Whig K, Segrist E, Li M, Kamalia B, Castellana L, Ayyanathan K, Cardenas-Diaz FL, Morrisey EE, Truitt R, Yang W, Jurado K, Samby K, Ramage H, Schultz DC, Cherry S. Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2. Cell Rep. 2021 Apr 6;35(1):108959. doi: 10.1016/j.celrep.2021.108959. Epub 2021 Mar 23. PMID: 33811811

Kitamura N, Sacco MD, Ma C, Hu Y, Townsend JA, Meng X, Zhang F, Zhang X, Ba M, Szeto T, Kukuljac A, Marty MT, Schultz D, Cherry S, Xiang Y, Chen Y, Wang J. Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors. J Med Chem. 2021 Apr 23;. doi: 10.1021/acs.jmedchem.1c00509. [Epub ahead of print] PubMed PMID: 33891389.

Zarkoob H, Allué-Guardia A, Chen YC, Jung O, Garcia-Vilanova A, Song MJ, Park JG, Oladunni F, Miller J, Tung YT, Kosik I, Schultz D, Yewdell J, Torrelles JB, Martinez-Sobrido L, Cherry S, Ferrer M, Lee EM. Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents. bioRxiv. 2021 May 12;. doi: 10.1101/2021.05.11.443693. PubMed PMID: 34013274; PubMed Central PMCID: PMC8132232.

Abbey D, Conlon D, Rainville C, Elwyn S, Quiroz-Figueroa K, Billheimer J, Schultz DC, Hand NJ, Cherry S, Radar DJ. Lipid Droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism. Clin Transl Sci. Clin Transl Sci. 2021 Jun 22;. doi: 10.1111/cts.12988. [Epub ahead of print] PubMed PMID: 34156146.

Li M, Ferretti M, Ying B, Descamps H, Lee E, Dittmar M, Lee JS, Whig K, Kamalia B, Dohnalová L, Uhr G, Zarkoob H, Chen YC, Ramage H, Ferrer M, Lynch K, Schultz DC, Thaiss CA, Diamond MS, Cherry S.  Pharmacological activation of STING blocks SARS-CoV-2 infection.  Sci Immunol. 2021 May 18;6(59):eabi9007. doi: 10.1126/sciimmunol.abi9007.PMID: 34010142

Liu X, Verma A, Garcia G, Ramage H, Myers RL, Lucas A, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition.  Proc Natl Acad Sci. 2021 Oct 19;118(42):e2113401118. doi: 10.1073/pnas.2113401118. Epub 2021 Sep 30. PMID: 34593624  (medRxiv. 2021 Jul 21:2021.02.17.21251933. doi: 10.1101/2021.02.17.21251933. Preprint. PMID: 33655282)

2020

Loro E, Sengupta K, Bogdanovich S, Whig K, Schultz DC, Huryn DM, Khurana TS.  High-throughput Identification of Post-Transcriptional Utrophin Up-Regulators for Duchenne Muscle Dystrophy (DMD) Therapy. Sci Rep 2020 10 (1), 4039. PMID 32111917.

Guo J, Chaney KE, Choi K, Witek G, Patel AV, Xie H, Lin D, Whig K, Xiong Y, Schultz DC, Ratner N, Field J. Polo-like kinase 1 as a therapeutic target for malignant peripheral nerve sheath tumors (MPNST) and schwannomas. Am J Cancer Res. 2020 Mar 1;10(3):856-869. eCollection 2020.PMID: 32266095

Xu Y, Liu R, Leu NA, Zhang L, Ibragmova I, Schultz DC, Wang PJ. A cell-based high-content screen identifies isocotoin as a small molecule inhibitor of the meiosis-specific MEIOB-SPATA22 complex. Biol Reprod. 2020 Aug 4;103(2):333-342. PMID: 32463099

2019

Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL.  Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell. 2019 Feb 21;73(4):684-698.e8. doi: 10.1016/j.molcel.2019.01.021. Epub 2019 Feb 14.PMID: 30773298

Hackett BA, Dittmar M, Segrist E, Pittenger N, To J, Griesman T, Gordesky-Gold B, Schultz DC, Cherry S. Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses.  MBio. 2019 Jul 9;10(4). pii: e01446-19. doi: 10.1128/mBio.01446-19. PMID: 31289184

Rivera OD, Mallory MJ, Quesnel-Vallières M, Chatrikhi R, Schultz DC, Carroll M, Barash Y, Cherry S, Lynch KW. Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia.  Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2014967118. doi: 10.1073/pnas.2014967118.PMID: 33876749

2017

Guo J, Grovola MR, Xie H, Coggins G, Duggan P, Hasan R, Huang J, Lin D, Song D, Witek G, Berritt S, Schultz DC, Field J. Comprehensive pharmacological profiling of neurofibromatosis cell lines. Am J Cancer Res. 2017 Apr 1;7(4):923-934. eCollection 2017.PMID:28469964

2016

Rausch K, Hackett BA, Weinbren NL, Reeder SM, Sadovsky Y, Hunter CA, Schultz DC, Coyne CB, Cherry S. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815. doi: 10.1016/j.celrep.2016.12.068. PMID: 28099856