Special Seminars/Events

Symposium Schedule

Seminars sponsored by the Department that are not included in any seminar series. These special lectures include faculty recruitment seminars, thesis defense talks, special symposia, and other events. Upcoming special seminars and events will be added here.

Structural Mass Spectrometry Symposium

In Honor of Walter Englander, PhD

Sponsored by the Department of Biochemistry and Biophysics.

**We are now oversubscribed. To be placed on our waitlist, please register here. If you are no longer planning on attending, please contact Kushol Gupta at kgupta@upenn.edu know as soon as possible so we can take others off the waitlist!

Note that is only an in-person event, and no remote/video options are planned!**

Time, Date:

Tuesday, May 16th, 2023

8:00 AM – 5:30 PM

Free to the Public

Location:

Perelman School of Medicine | University of Pennsylvania

Smilow Center for Translational Research

3400 Civic Center Blvd, Philadelphia PA 19104

Smilow Auditorium

parking map for symposium attendees

Public Transit | If you are arriving by regional rail, the Penn Medicine stop is the closest to the day’s events. If subway, the Green Line Trolley to 37^th and Spruce would be the closest stop – after exiting the trolley stop, proceed south down Spruce Street.

Parking | These indoor parking garages are closest to where we will be for the day –

Parking at the Perelman Center

Parking at the University Museum

Smilow Entry | The event will be located in the Smilow Commons and Arthur H Rubenstein Auditorium in the Smilow Center for Translational Research (3400 Civic Center Blvd), which is located in the precinct of the aforementioned parking garages. Take advantage of this guide on how to enter the building and find the lunch and auditorium.

Food | Thanks to our friends at Protein Metrics, Trajan, ThermoFisher Scientific, and Waters, participants will be provided continental breakfast, lunch, and plenty of coffee!

Internet | All visitors are welcome to use the SSID “Air-Pennnet Guest” for WiFi. After connecting, use a web browser to complete registration.

Schedule:

	Talk Title	Speaker, Institution
9:00 AM-10:00 AM	Continental Breakfast
Morning Session

10:00 AM	Opening Remarks	Kristen Lynch (University of Pennsylvania)
	Introduction of Walter Englander	Josh Wand (Texas A&M University, Englander Lab Alumnus)
10:10 AM – 11:00 AM	“MS and HX: Made for Each Other”	Walter Englander (University of Pennsylvania)
11:00 AM – 11:15 AM	Coffee Break
11:15 AM – 11:30 AM	TBA	Yoshi Hamuro (Johnson and Johnson, Englander Lab Alumnus)
11:30 PM – 12:15 PM	“Following in Walter's Footsteps with HX-MS”	Tobin Sosnick (Professor, U. of Chicago, Englander Lab Alumnus)
12:15 PM – 1:15 PM	Lunch and Posters
Afternoon Session
1:15 PM – 2:00 PM	“Asymmetric Genomic RNA Egress and Virus Disassembly Driven by Capsid Genome Rearrangements by HDXMS and cryo-EM“	Ganesh Anand (Professor, Pennsylvania State University)
2:00 PM – 2:15 PM	“Hyperosmotic Stress Allosterically Reconfigures Betaine Binding Pocket in BetP”	Theresa Buckley (Graduate Student, Anand Lab, Pennsylvania State University)
2:15 PM – 2:30 PM	“Timeline of Changes in Spike Conformational Dynamics in Emergent SARS-CoV-2 Variants Reveal Progressive Stabilization of Trimer Stalk with Altered NTD Dynamics”	Varun Venkatakrishnan (Graduate Student, Anand Lab, Pennsylvania State University)
2:30 PM – 3:15 PM	“PARP2 undergoes enhanced allosteric activation-induced structural changes that facilitate PARPi-induced DNA retention”	Emily Smith (BMB Graduate Student, Black Lab, University of Pennsylvania)
3:15 PM – 3:30 PM	Coffee Break
3:30 PM – 4:15 PM	“Hacking Structural Biology for Drug Discovery Using Protein” Footprinting Based Mass Spectrometry”	Mark Chance (Professor, Case Western University)
4:15 PM – 5:00 PM	“Structural and Mechanistic Insights into Hsp104 Function Revealed by Synchrotron X-ray Footprinting”	Elizabeth Sweeny (Assistant Professor, Medical College of Wisconsin, BMB Alumna)
	Closing Remarks
5:00 PM	End of Event

Confirmed speakers to-date include:

Tobin Sosnick | University of Chicago

Elizabeth Sweeny | Medical College of Wisconsin

Walter Englander | University of Pennsylvania

Ganesh Anand | Pennsylvania State University

Mark Chance | Case Western University

Emily Smith | University of Pennsylvania

Josh Wand | Texas A&M University

Those interested in submitting an abstract for a poster or short talk should email the abstract to Kushol Gupta (kgupta@upenn.edu) by April 15^th, 2023.

About Walter Englander, PhD.

headshot of Walter Englander Dr. S. Walter Englander was born into an immigrant working-class Orthodox Jewish family in Baltimore, Maryland. He spent his early years with thoughts of becoming a rabbi and dreams of becoming a professional baseball player. Instead he worked his way through the University of Maryland in physics and math and continued at the University of Pittsburgh where he earned a PhD in biophysics. He spent his postdoctoral years at the National Institutes of Health and Dartmouth before settling at the University of Pennsylvania as an associate professor in 1967. He was named the Jacob Gershon-Cohen Professor of Medical Science in 1990 and spent the remainder of his career at UPenn as a central member of the Department of Biochemistry and Biophysics, training countless students and postdocs, mentoring faculty, and continuing funded research into his 90s. He was also a key player in departmental softball games. In his professional career Dr. Englander developed the eld of hydrogen exchange (HX) — both methods and interpretation — which now make HX among the most powerful of molecular biophysical technologies. He used HX to show that proteins fold by way of stepwise foldon units, which he discovered, and how the vast family of AAA+ protein machines work. His many contributions to protein and nucleic acid biophysics have been recognized by honors including election to the National Academy of Sciences, the American Academy of Arts and Sciences, the Founders Award of the Biophysical Society — to name a few.