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Liu Lab in Journal of Biological Chemistry
August 2021
Human DIMT1 generates N 26,6 A-dimethylation-containing small RNAs
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Shorter Lab in Journal of Molecular Biology
August 2021
Nuclear-import receptors counter deleterious phase transitions in neurodegenerative disease
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Moiseenkova-Bell Lab in Structure
August 2021
Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium
Read more.

Collaborative paper from Shorter and Marmorstein Labs in Nature
August 2021
DAXX represents a new type of protein-folding enabler
Read more.

Chang Lab in Nature Communications
August 2021
In situ ultrastructures of two evolutionarily distant apicomplexan rhoptry secretion systems
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Collaborative paper from Shorter Lab in Cell
August 2021
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire
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Collaborative Paper from Moiseenkova-Bell Lab in Journal of Virology
August 2021
Context-Specific Function of the Engineered Peptide Domain of PHP.B
Read more.

Matt Gazzara awarded Blavatnik Family Fellowship
July 2021
Congratulations to Matt Gazzara, Barash and Lynch Lab member, recipient of a Blavatnik Family Fellowship in Biomedical Research
Read more.

Van Duyne Lab in Genome Biology
June 2021
Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons
Read more.

Burslem Lab in Journal of Medicinal Chemistry
May 2021
Focused Libraries for Epigenetic Drug Discovery: The Importance of Isosteres
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Sgourakis Lab in Nature Communications
May 2021
TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap
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Marmorstein & Peterson Labs in Structure
May 2021
Molecular mechanism of N-terminal acetylation by the ternary NatC complex
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Wilson and Matschinsky in Frontiers in Physiology
May 2021
Metabolic Homeostasis in Life as We Know It: Its Origin and Thermodynamic Basis
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Garcia Lab Collaborates on Paper in Molecular Cell
May 2021
Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML
Read more.

Lynch, Cherry, and Barash Labs in PNAS
April 2021
Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia
Read more.

Murakami Lab in Science Advances
April 2021
Structure of TFIIK for phosphorylation of CTD of RNA polymerase II
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Cherry Lab in Cell Reports
April 2021
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
Read more.
 

Vinogradov Lab in Journal of Physical Chemistry A
April 2021
syn-Diarylphthalimidoporphyrins: Effects of Symmetry Breaking on Two-Photon Absorption and Linear Photophysical Properties
Read more.

Garcia Lab in Journal of Proteome Research
March 2021
Improved SILAC Quantification with Data-Independent Acquisition to Investigate Bortezomib-Induced Protein Degradation
Read more.

Heidi Elashal awarded NSF Fellowship
March 2021
Elashal, Liu Lab member and BMB Student, received NSF Grad Research Fellowship

Daniela Fera named a 2021 Cottrell Scholar
March 2021
Congratulations Daniela Fera, honored for making an impact on science, on students, and across academia.

Sharp Lab in Journal of Chemical Information and Modeling
March 2021
Computational Graphics Software for Interactive Docking and Visualization of Ligand-Protein Complementarity
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Burslem on ACS Chemical Biology Advisory Board
March 2021
Congratulations to George Burslem on being named a member of Early Career Advisory Board for ACS Chemical Biology

Daldal and Murakami Labs in Nature Communications
February 2021
Cryo-EM structures of engineered active bc 1-cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes
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Sgourakis Lab in Nature Communications
January 2021
Backbone-independent NMR resonance assignments of methyl probes in large proteins
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Sellmyer Lab in ACS Chemical Biology
January 2021
A Chemical Approach for Programmable Protein Outputs Based on Engineered Cell Interactions.
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Gupta/Van Duyne Lab in Structure
December 2020
Allosteric HIV integrase inhibitors promote formation of inactive branched polymers via homomeric carboxy-terminal domain interactions.
Read more.

Vinogradov Lab in Journal of Physical Chemistry A
December 2020
Three-Photon Spectroscopy of Porphyrins
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Shorter Lab in Elife
December 2020
Therapeutic genetic variation revealed in diverse Hsp104 homologs
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Petersson & Rhoades Labs in Journal of the American Chemical Society
December 2020
Effects of Glutamate Arginylation on α-Synuclein: Studying an Unusual Post-Translational Modification through Semisynthesis
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Shorter Lab in Cell Reports
December 2020
TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease
Read more.

Lynch & Cherry Labs in Elife
December 2020
Viral-induced alternative splicing of host genes promotes influenza replication
Read more.

Petersson & Rhoades Labs in Chembiochem
December 2020
Chemoenzymatic Semi-synthesis Enables Efficient Production of Isotopically-Labelled α-Synuclein with Site-specific Tyrosine Phosphorylation
Read more.

Kushol Gupta and the Johnson Foundation Biophysical and Structural Biology Core (JF-BSB) receive S10 Grant
November 2020
Congratulations Kushol Gupta and the Johnson Foundation Biophysical and Structural Biology Core (JF-BSB) for a successful S10 grant for a new multi-wavelength Beckman-Coulter Optima analytical ultracentrifuge (AUC).  AUC has long been used to separate macromolecules in solution based on their hydrodynamic properties and to ascertain information about size and shape, accelerating study in all areas of basic biomedical research, from structural biology to the characterization of biologics and gene vectors.  The Optima AUC will provide a state-of-the art advance in multi-wavelength technology, allowing investigators at Penn the ability to approach a range of questions not previously possible in complex systems, including mass and stoichiometry, shape, aggregation state and oligomerization, ligand binding, conjugation efficiency, and polydispersity.  Importantly, this S10 award places Penn as one of the few academic centers providing core access to such instrumentation. 

Cherry Lab in mBio
October 2020
DDX56 Binds to Chikungunya Virus RNA To Control Infection.
Read more.

Ben Black receives Penn Medicine Award
October 2020
Congratulations to Ben Black, PhD, recipient of Stanley Cohen Award for Excellence in Biomedical Research.
Read more.

Shorter Lab in Journal of American Chemical Society
September 2020
Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers.
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Van Duyne Lab in Retrovirology
August 2020
Influence of the amino-terminal sequence on the structure and function of HIV integrate.
Read more.

Liu Lab in Journal of Biological Chemistry
July 2020
Structural and Catalytic Roles of the Human 18S rRNA Methyltransferases DIMT1 in Ribosome Assembly and Translation.
Read more.

Shorter Lab in eLife
June 2020
Skd3 (human CLPB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations.
​​​​​​​Read more.

Collaborative paper between Murakami lab and Dominguez lab in Science Advances
June 2020
Cryo-EM Structure of NPF-bound Human Arp2/3 Complex and Activation Mechanism. Read more.

Lynch Lab in RNA
June 2020
Meta-Analysis of Transcriptomic Variation in T cell Populations Reveals both Variable and Consistent Signatures of Gene Expression and Splicing.
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Liu Lab in PNAS
April 2020
Coordination of mRNA and tRNA Methylations by TRMT10A.
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Lynch Lab in Nucleic Acids Research
April 2020
Reciprocal regulation of hnRNP C and CELF2 through translation and transcription tunes splicing activity in T cells.
Read more.

Shorter Lab studies on YouTube
April 2020
Janet Iwasa's animation of ClpP mechanism based on work from the Shorter Lab.
See more.

Vera Moiseenkova-Bell Biophysical Society Profile
April 2020
Moiseenkova-Bell shares highlights of her professional and personal background.
Read more.

Englander and Shorter Labs in PNAS
April 2020
Structural and kinetic basis for the regulation and potentiation of Hsp104 function.
Read more.

Black Lab in Science
April 2020
Structural basis for allosteric PARP-1 retention on DNA breaks.
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Kohli Lab in Angewandte Chemie
April 2020
Nucleobase Modifiers Identify TET Enzymes as Bifunctional DNA Dioxygenases Capable of Direct N-Demethylation.
Read more.

Matschinsky receives Rolf Luft Award
February 2020
Congratulations Franz M. Matschinsky, MD for receiving the 2020 Rolf Luft Award from the Karolinska Institute for outstanding scientific contribution in endocrinology and diabetes.
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Garcia lab in Nature Communications
February 2020
A computational platform for high-throughput analysis of RNA sequences and modifications by mass spectrometry.
Read more.

Marmorstein lab in Nature Communications
February 2020
Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK. Read more.

Shorter and Englander labs in Journal of Biological Chemistry
February 2020
Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting.
Read more.

Vinogradov lab in Nanoscale
January 2020
In vivo deep-tissue microscopy with UCNP/Janus-dendrimers as imaging probes: resolution at depth and feasibility of ratiometric sensing.
Read more.

Moiseenkova-Bell lab in Cell Calcium
January 2020
Structural insights into the gating mechanisms of TRPV channels.
Read more.

Marmorstein lab in Nature Structural & Molecular Biology
January 2020
Molecular basis for acetyl-CoA production by ATP-citrate lyase.
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Dreyfuss lab in Nature Communications
January 2020
U1 snRNP regulates cancer cell migration and invasion in vitro.
Read more.

Shorter lab in Molecular Cell
January 2020
Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two DistinctTypes of ALS/FTD-Linked FUS Mutations.
Read more.

Lynch and Garcia labs in Genome Research
December 2019
Deep profiling and custom databases improve detection of proteoforms generated by alternative splicing.
Read more.

Murakami and Wilusz labs in PNAS
November 2019
The capping enzyme facilitates promoter escape and assembly of a follow-on preinitiation complex for reinitiation.
Read more.

Wilusz lab in Genes & Development
November 2019
The Integrator complex cleaves nascent mRNAs to attenuate transcription.
Read more.

Dreyfuss lab in Molecular Cell
November 2019
A Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells.
Read more.

Chang Named 2019 Packard Fellow
October 2019
Congratulations to Yi-Wei Chang for receiving the 2019 Packard Fellowship for Science and Engineering.
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Garcia lab in Nature
October 2019
Alcohol metabolism contributes to brain histone acetylation.
Read more.

Moiseenkova-Bell lab in Elife
September 2019
Molecular mechanism of TRPV2 channel modulation by cannabidiol.
Read more.

Garcia lab in Scientific Reports
September 2019
A mass spectrometry-based assay using metabolic labeling to rapidly monitor chromatin accessibility of modified histone proteins.
Read more.

Lynch lab in Cell Reports
September 2019
RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery.
Read more.

Shorter lab in Cell Reports
August 2019
Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.
Read more.

Garcia lab in Cancer Research
July 2019
Epigenomic Reordering Induced by Polycomb Loss Drives Oncogenesis but Leads to Therapeutic Vulnerabilities in Malignant Peripheral Nerve Sheath Tumors.
Read more.

Black lab in Cell
July 2019
Human Artificial Chromosomes that Bypass Centromeric DNA.
Read more.

Wilusz lab in Nucleic Acids Research
July 2019
An improved method for circular RNA purification using RNase R that efficiently removes linear RNAs containing G-quadruplexes or structured 3' ends.
Read more.

Dutton/Discher lab in PCCP
June 2019
Ultrafast flavin/tryptophan radical pair kinetics in a magnetically sensitive artificial protein. Read more.

Wilusz lab in Genes & Development
June 2019
Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors.
Read more.

Marmorstein and Petersson labs in Structure
May 2019
Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex.
Read more.

Garcia lab in Genome Research
May 2019
One minute analysis of 200 histone posttranslational modifications by direct injection mass spectrometry.
Read more.

Sharp & Harvey labs in Biophysical Journal 
April 2019
DNA Conformational Changes Play a Force-Generating Role during Bacteriophage Genome Packaging.
Read more.

Marmorstein & Black labs in JBC 
April 2019
The HIRA histone chaperone complex subunit UBN1 harbors H3/H4 and DNA binding activity.
Read more.

Englander and Shorter labs in PNAS 
March 2019
Walter Englander and Jim Shorter labs team up to use HX to determine dynamic behavior of Hsp104.
Read more.

Marmorstein lab in JBC
March 2019
ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis.
Read more.

Vinogradov lab in Cell Metabolism
January 2019
Sergei Vinogradov and lab develop a new faster oxygen sensor able to monitor oxygen metabolism deep in tissues.
Read more.

Garcia, Black, and Englander in Structure
November 2018
The Garcia, Black and Englander labs combine forces to achieve a high-resolution view of histone tail dynamics during nucleosome assembly.
Read more.

Shorter in Molecular Cell
August 2018
Jim Shorter and Nancy Bonini show PARP inhibitors limit TDP-43 aggregation.
Read more.

Marmorstein & Gupta in Nature Communications
August 2018
Ronen Marmorstein, Kushol Gupta and collaborators uncover the architecture of the HIRA complex required for accurate chromatin composition.
Read more.

Shorter in PNAS
June 2018
Jim Shorter helps identify more roles for amyloid fibrils in viral infection.
Read more.

Lynch Lab in Nature Communications
June 2018
Lynch Lab and colleagues identify new mechanism of splicing in the flu virus and human cells.
Read more.

Garcia awarded Biemann Medal
June 2018
Ben Garcia has been awarded the Biemann Medal by the American Society for Mass Spectrometry - one of the highest honors that the society awards, given in recognition of significant achievement in early stages of a career.
Read more.

Garcia in Cell Reports
June 2018
New LcRNAs identified in ants thanks to Mass Spectrometry and a collaborative effort between Ben Garcia and Roberto Bonasio.
Read more.

Wilusz in Genes & Development
May 2018
Congrats to the Wilusz Lab for their new paper showing how circular RNAs move to the cytoplasm.
Read more.

Shorter in Cell
April 2018
Jim Shorter and colleagues describe a new way to dissociate toxic protein aggregates. Read more.

Dutton & Moser in J. Royal Soc. Interface
April 2018
The Les Dutton and Chris Moser groups publish a new synthetic biliprotein design.
Read more.

Vinogradov & Garcia in PNAS
April 2018
Sergei Vinogradov, Ben Garcia and co-workers at Penn describe the impact of oxygen on the microbiome.
Read more.

Dean’s Innovation Award
July 2017
Congratulations to Ben Black, Professor in the department, for being the recipient of the inaugural Dean’s Innovation Award in recognition of his outstanding and creative research!