Bruce D. Freedman V.M.D., Ph.D
Graduate Group Affiliations
Contact information
368E Old Vet Bldg.
3800 Spruce Street
Philadelphia, PA 19104
3800 Spruce Street
Philadelphia, PA 19104
Office: (215) 573-8218
Fax: (215) 898-0719
Fax: (215) 898-0719
Email:
bruce@vet.upenn.edu
bruce@vet.upenn.edu
Publications
Links
Search PubMed for articles
Immunology graduate group faculty webpage.
Link to Freedman in Research Newsletter
Search PubMed for articles
Immunology graduate group faculty webpage.
Link to Freedman in Research Newsletter
Education:
B.S.
Dickinson College, 1980.
M.S.
Pennsylvania State University, 1983.
V.M.D.
University of Pennsylvania, 1987.
Ph.D.
University of Pennsylvania, 1992.
Permanent linkB.S.
Dickinson College, 1980.
M.S.
Pennsylvania State University, 1983.
V.M.D.
University of Pennsylvania, 1987.
Ph.D.
University of Pennsylvania, 1992.
Description of Research Expertise
Research InterestsSignal transduction mechanisms in immune cells
Research Summary
The general focus of the laboratory is physiological processes that regulate lymphocyte and macrophage development and function. We are specifically interested in pathways that regulate calcium signaling in T and B cells and the mechanisms by which diverse and complex inputs (antigen and coactivating and inhibitory stimuli) are encoded as functionally specific Ca2+ signals and translated into appropriate biological responses that regulate lymphocyte development and differentiation. We are also interested in the viral and cellular determinants of viral tropism and pathogenesis. We have focused on the signal transduction pathways activated in human macrophages and T cells by HIV-1 envelope protein (gp120) upon interaction with CD4 and chemokine receptors. Our goal is to understand the functional consequences of signaling on virus entry, post-entry steps of viral replication, and the consequences on target cell functions apart from infection.
Selected Publications
Freedman, B.D., Liu, Q-H., DelCorno, M., Collman, R.: HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages. Immunological Research 27: 261-276, 2003.Wells, A.D., Liu, Q-H, Hondowicz, B.H., Zhang, J., Turka, L.A., and Freedman, B.D. : Regulation of T Cell Activation and Tolerance by PLC 1-dependent Integrin Avidity Modulation. Journal of Immunology 170: 4127-4133, 2003.
Liu, Q-H, Fleischmann, B.K., Hondowicz, B., Maier, C., Turka, L., Yui, K., Kotlikoff, M.I., Wells, A.D., and Freedman, B.D. : Modulation of Kv Channel Expression and Function by TCR and Costimulatory Signals during Peripheral CD4+ Lymphocyte Differentiation. J. Experimental Medicine 196: 897-90, 2002.
Myung, P.S., Jordan, M.S., Punt, J.A., Liu, Q-H, Judd, B.A., Sigmund, C.D., Freedman, B.D., Koretzky, G.A.: Differential requirements for SLP-76 domains in T cell development and function. Immunity 15: 1011-26, 2001.
Del Corno, M., Liu, Q-H. Schols, D, de Clercq, E, Gessani, S. Freedman B. D., Collman R. G. : HIV-1 gp120 activation of Pyk2 and mitogen-activated protein (MAP) kinases in primary macrophages mediated by CCR5 and CXCR4 through a calcium-dependent, pertussis toxin-insensitive pathway. Blood 98: 2909-16, 2001.
Peterson, E.J., Woods, M.L., Dmowski, S.A., Derimanov, G., Judd, B.A., Jordan, M.S., Wu, J.N., Myung, P.S., Liu, Q-H, Pribila, J.T., Freedman, B.D., Shimizu, Y., Koretzky, G.A.: Coupling of the TCR to integrin activation by SLAP-130/Fyb. Science 293: 2263-65, 2001.
Collman, R.G., Yi, Y., Liu, Q-H, and Freedman, B.D.: Chemokine signaling and HIV-1 fusion mediated by macrophage CXCR4: Implications for target cell tropism. Journal of Leukocyte Biology 68: 318-23, 2000.
Freedman, B.D., Liu Q.H., Gaulton, G., Kotlikoff, M.I., Heschler, J., and Fleischmann, B.K.: ATP-evoked Ca2+ transients and currents in murine thymocytes: Possible role for P2X receptors in death by neglect. European Journal of Immunology 29: 1635-1646, 1999.