Stephan A. Grupp, MD, PhD
Associate Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations
Contact information
Oncology/BMT CTRB 3006
3501 Civic Center Blvd.
Philadelphia, PA 19104
3501 Civic Center Blvd.
Philadelphia, PA 19104
Office: (215) 590-5475
Fax: (215) 590-3770
Fax: (215) 590-3770
Email:
GRUPP@EMAIL.CHOP.EDU
GRUPP@EMAIL.CHOP.EDU
Publications
Education:
B.S.
University of Cincinnati (Magna cum laude), 1981.
Ph.D.
University of Cincinnati College of Medicine, 1985.
M.D.
University of Cincinnati College of Medicine, 1987.
Permanent linkB.S.
University of Cincinnati (Magna cum laude), 1981.
Ph.D.
University of Cincinnati College of Medicine, 1985.
M.D.
University of Cincinnati College of Medicine, 1987.
Description of Research Expertise
Research InterestsRole of the B cell receptor complex in B cell signaling and lymphoid development
Research Summary
Our major research interest is in the area of B cell development from committed lymphoid progenitor to mature B cell. The B cell receptor complex lends antigen specificity to most of the functions of the mature B cell. These include antigen binding for subsequent presentation to helper T cells, as well as the process of antigen-mediated B cell activation. In pre-B cells, immunoglobulin (m) heavy chain is part of a pre-B cell receptor complex, which also includes the Iga/b heterodimer and surrogate light chains. Current studies ongoing in the lab include the role of m heavy chain in early B cell development, specifically the transition through the pre-B cell stage, apoptotic cell death, allelic exclusion and activation of light chain rearrangement. These studies are being carried out in vivo using IgM transgenic mice and in vitro using transfected pro- and pre-B cell lines. Recent studies have helped to confirm the importance of Iga/b in B cell development as well as elucidate the relative contributions of signaling via Iga/b and surrogate light chains in both development and allelic exclusion.
Selected Publications
Cuvelier G D E, Kariminia A, Fujii H, Aslanian S, Wall D, Goldman F, Grupp S A, Dunn S E, Krailo M, Shapiro L H, Gilman A, Schultz K R: Anti-CD13 Abs in children with extensive chronic GVHD and their relation to soluble CD13 after allogeneic blood and marrow transplantation from a Children's Oncology Groups Study, ASCT0031. Bone marrow transplantation 45(11): 1653-7, Nov 2010.Yu Alice L, Gilman Andrew L, Ozkaynak M Fevzi, London Wendy B, Kreissman Susan G, Chen Helen X, Smith Malcolm, Anderson Barry, Villablanca Judith G, Matthay Katherine K, Shimada Hiro, Grupp Stephan A, Seeger Robert, Reynolds C Patrick, Buxton Allen, Reisfeld Ralph A, Gillies Steven D, Cohn Susan L, Maris John M, Sondel Paul M, : Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. The New England journal of medicine 363(14): 1324-34, Sep 2010.
Seif Alix E, Manno Catherine S, Sheen Cecilia, Grupp Stephan A, Teachey David T: Identifying autoimmune lymphoproliferative syndrome in children with Evans syndrome: a multi-institutional study. Blood 115(11): 2142-5, Mar 2010.
Barrett David, Fish Jonathan D, Grupp Stephan A: Autologous and allogeneic cellular therapies for high-risk pediatric solid tumors. Pediatric clinics of North America 57(1): 47-66, Feb 2010.
Verneris Michael R, Grupp Stephan A: Natural killer cell consolidation for acute myelogenous leukemia: a cell therapy ready for prime time? Journal of clinical oncology : official journal of the American Society of Clinical Oncology 28(6): 909-10, Feb 2010.
Pulsipher Michael A, Wall Donna A, Grimley Michael, Goyal Rakesh K, Boucher Kenneth M, Hankins Patricia, Grupp Stephan A, Bunin Nancy: A phase I/II study of the safety and efficacy of the addition of sirolimus to tacrolimus/methotrexate graft versus host disease prophylaxis after allogeneic haematopoietic cell transplantation in paediatric acute lymphoblastic leukaemia (ALL). British journal of haematology 147(5): 691-9, Dec 2009.
Reid Gregor S D, Shan Xiaochuan, Coughlin Christina M, Lassoued Wiem, Pawel Bruce R, Wexler Leonard H, Thiele Carol J, Tsokos Maria, Pinkus Jack L, Pinkus Geraldine S, Grupp Stephan A, Vonderheide Robert H: Interferon-gamma-dependent infiltration of human T cells into neuroblastoma tumors in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research 15(21): 6602-8, Nov 2009.
Pulsipher Michael A, Boucher Kenneth M, Wall Donna, Frangoul Haydar, Duval Michel, Goyal Rakesh K, Shaw Peter J, Haight Ann E, Grimley Michael, Grupp Stephan A, Kletzel Morris, Kadota Richard: Reduced-intensity allogeneic transplantation in pediatric patients ineligible for myeloablative therapy: results of the Pediatric Blood and Marrow Transplant Consortium Study ONC0313. Blood 114(7): 1429-36, Aug 2009.
Milone Michael C, Fish Jonathan D, Carpenito Carmine, Carroll Richard G, Binder Gwendolyn K, Teachey David, Samanta Minu, Lakhal Mehdi, Gloss Brian, Danet-Desnoyers Gwenn, Campana Dario, Riley James L, Grupp Stephan A, June Carl H: Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Molecular therapy : the journal of the American Society of Gene Therapy 17(8): 1453-64, Aug 2009.
Teachey David T, Greiner Robert, Seif Alix, Attiyeh Edward, Bleesing Jack, Choi John, Manno Catherine, Rappaport Eric, Schwabe Dirk, Sheen Cecilia, Sullivan Kathleen E, Zhuang Hongming, Wechsler Daniel S, Grupp Stephan A: Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome. British journal of haematology 145(1): 101-6, Apr 2009.