Caryn Lerman, Ph.D.

faculty photo
John H. Glick, M.D. Professor in Cancer Research
Department: Psychiatry
Graduate Group Affiliations

Contact information
Center for Interdisciplinary Research on Nicotine Addiction (CIRNA)
3535 Market Street, Suite 4100
Philadelphia, PA 19104
Office: 215-746-7141
Fax: 215-746-7140
B.S. (Psychology)
Pennsylvania State University , 1981.
M.S. (Psychology)
University of Southern California , 1982.
Ph.D. (Clinical Psychology)
University of Southern California , 1984.
(Internship in Clinical/Medical Psychology)
Boston Veterans Administration Medical Center , 1985.
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Description of Research Expertise

Dr. Lerman's work translates research in neuroscience, pharmacology, genetics, and behavioral science to develop improved interventions for health risk behavior change.

Selected Publications

Loughead J, Wileyto EP, Valdez NJ, Sanborn P, Tang K, Strasser AA, Ruparel K, Ray R, Gur RC, Lerman C.: Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype. Molecular Psychiatry 14(8): 820-826, 2009.

Schnoll RA, Patterson F, Wileyto EP, Heitjan D, Shields AE, Asch D, Lerman C. : Effectiveness of extended duration transdermal nicotine therapy: a randomized trial. Annals of Internal Medicine 152(3): 144-151, 2010.

Loughead J, Ray R, Wileyto EP, Ruparel K, Sanborn P, Siegel S, Gur RC, Lerman C.: Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers. Biological Psychiatry 67(8): 715-721, 2010.

Ray R, Ruparel K, Newberg A, Wileyto EP, Loughead J, Divgi C, Blendy JA, Logan J, Zubieta JK, Lerman C. : Human mu opioid receptor (OPRM1 A118G) polymorphism is associated with brain mu opiod receptor binding potential in smokers. Proceedings of the National Academy of Sciences USA 108(22): 9268-9273, 2011.

Mrazek DA, Lerman C. : Pharmacogenomics: facilitating clinical implementation. Journal of the American Medical Association 306(3): 304-305, 2011.

Lerman C, Gu H, Loughead J, Ruparel K, Yang Y, Stein EA.: Large scale brain network coupling predicts acute nicotine abstinence effects on craving and cognitive function. JAMA Psychiatry 71(5): 523-530 2014.

Lerman C, Schnoll, RA, Hawk LW, Cinciripini P, George TP, Wileyto EP, Swan GE, Benowitz NI, Heitjan DF, Tyndale RF, PGRN-PNAT Research Group.: Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial. The Lancet Respiratory Medicine 3(2): 131-138, 2015.

Loughead J, Wileyto EP, Ruparel K, Falcone M, Hopson R, Gur R, Lerman C. : Working memory-related neural activity predicts future smoking relapse. Neuropsychopharmacology 40(6): 1311-1320, 2015.

Falcone M Cao W Bernardo L Tyndale RF Loughead J Lerman C : Brain responses to smoking cues differ based on nicotine metabolism rate. Biological Psychiatry 80(3): 190-197, 2016.

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Last updated: 08/04/2016
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