Lewis A. Chodosh, M.D., Ph.D.

faculty photo
Professor of Cancer Biology
Department: Cancer Biology

Contact information
421 Curie Blvd.
Philadelphia, PA 19104
Office: (215) 898-1321
Fax: (215) 573-6725
Lab: (215) 898-0006
B.S. (Molecular Biophysics & Biochemistry)
Yale University, 1981.
Ph.D. (Biochemistry)
Massachusetts Institute of Technology, 1988.
Harvard Medical School, 1989.
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Description of Research Expertise

Research Interests
Genetically engineered mouse models for breast cancer initiation, metastasis, and recurrence.
Normal developmental biology of the mammary gland.
Tumor dormancy.
Stem cells in breast cancer and mammary development.
Oncogenes and tumor suppressors in breast cancer.
Genomics and computational biology.
Non-invasive imaging.

Key words: Mouse models, cancer, oncogenes, targeted therapy, development, genomics, computational biology, stem cells, imaging.

Description of Research
Breast cancer is the most common cancer as well as the leading cause of death from cancer among women worldwide. The Chodosh laboratory uses genetically engineered mouse models to study the genes and mechanisms that cause breast cancer and that regulate normal mammary gland development. Particular areas of interest include: the function of oncogenes and tumor suppressor genes in breast cancer, metastasis, tumor dormancy and recurrence; the role of stem cells in cancer and the normal development of the mammary gland; the use of genomics and computational approaches to understand genetic programs in mammary development and breast cancer; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches such as PET, MRI, and bioluminescence to study tumor biology. These approaches employ a broad array of molecular, cellular, animal, human, and in silico model systems to study the function of key regulatory molecules in mammary gland and tumor biology.

Rotation Projects for 2015-2016
Rotation projects are available in each of the main areas of the lab.

Lab personnel:
George Belka – Director D
Jessica Blanchard - Research Specialist
Tatiana Blanchard - Research Specialist
Yan Chen – Research Specialist
Beth Chislock, Ph.D. - Postdoctoral Researcher
Samuel Getchell - Graduate Student
Samyutkta Mahendra - Research Specialist
Heather Martin, Ph.D. - Postdoctoral Fellow
Tien–chi Pan – Computational Biologist
Dhruv Pant – Computational Biologist
Lauren Pferdehirt - Graduate Student
Judith Smith – Lab Manager

Administrative Coordinator:
Katelyn Wichert

Selected Publications

Yeh ES, Vernon-Grey A, Martin H and Chodosh LA: Tetracycline-regulated mouse models of cancer. Cold Springs Harbor Protocol 2014.

Alvarez JV, Belka GK, Pan TC, Chen CC, Blankemeyer E, Alavi A, Karp JS and Chodosh LA: Oncogene pathway activation in mammary tumors dictates FDG-PET uptake. Cancer Research 74: 7583-7598, 2014.

Payne AW, Pant DK, Pan TC and Chodosh LA: Ceramide kinase promotes tumor cell survival and mammary tumor recurrence. Cancer Research 74: 6352-6563, 2014.

Feng Y, Pan TC, Pant DK, Chakrabarti KR, Alvarez JV, Ruth JR and Chodosh LA: SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling. Cancer Discovery Page: 790-803, 2014.

Alvarez JV, Pan TC, Ruth J, Feng Y, Zhou AY, Pant D, Grimley JS, Wandless TJ, DeMichele A, I-SPY 1 Trial Investigators and Chodosh LA: Par-4 down-regulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. Cancer Cell 24: 30-44, 2013.

Yeh ES, Belka GK, Vernon AE, Chen CC, Jung JJ and Chodosh LA: Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten. Proceedings of the National Academy of Sciences USA 115: 918-27, 2013.

Chen CC, Stairs DB, Boxer RB, Belka GK, Horseman ND, Alvarez JV and Chodosh LA: Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes & Development 26: 2154-2168, 2012.

Yeh, ES, Yang TW, Jung JJ, Gardner HP, Cardiff RD and Chodosh LA: Hunk is required for HER2/neu-induced mammary tumorigenesis. Journal of Clinical Investigation 121: 866-879, 2011.

Wertheim GBW, Yang TW, Pan TC, Ramne A, Liu Z, Gardner HP, Dugan KD, Kristel P, Kreike B, Vijver MJ, Cardiff RD and Chodosh LA: The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proceedings of the National Academy of Sciences USA 106(37): 15855-15860, 2009.

Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero C, Sterner CJ, Notarfrancesco K, Cardiff RD and Chodosh LA: The transcriptional repressor, Snail, promotes mammary tumor recurrence. Cancer Cell 8: 197-209, 2005.

Blakely CM, Stoddard AJ, Belka GK, Dugan KD, Notarfrancesco KL, Moody SE, D’Cruz CM, and Chodosh LA: Hormone-induced protection against mammary tumorigenesis is conserved in multiple rat strains and identifies a core gene expression signature induced by pregnancy. Cancer Research 66: 6421-6431, 2006.

Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portacarrero CP, Keister BA, Belka GK, Cho H, Rathmell J, Thompson CB, Birnbaum MJ, and Chodosh LA: Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation Cell Metabolism 4: 475-490, 2006.

Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE, and Chodosh LA: Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nature Cell Biology 9: 493-505, 2007.

Liu Z, Wang M, Alvarez JV, Bonney ME, Chen CC, D'Cruz C, Pan TC, Tadesse MG and Chodosh LA: Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo. Genome Biology 9: R180, 2008.

Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello NM, Haas NB, Rebbeck TR, Judkins A, Won KJ, Chodosh LA, Garcia BA, Stanger BZ, Feldman MD, Blair IA and Wellen KE: Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation. Cancer Metabolism Page: 306-319, 2014.

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Last updated: 07/29/2015
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