Robert J. Levy, MD
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations
Contact information
CHOP
Abramson Pediatric Research Center,
Room 702D
Philadelphia, PA 19104-4318
Abramson Pediatric Research Center,
Room 702D
Philadelphia, PA 19104-4318
Office: 215-590-6119
Fax: 215-590-5454
Fax: 215-590-5454
Email:
levyr@email.chop.edu
levyr@email.chop.edu
Publications
Links
Search PubMed for articles
Joseph Stokes Jr. Research Institute Faculty
Pharmacological Sciences Graduate Group Faculty
CHOP Provider Profile
Search PubMed for articles
Joseph Stokes Jr. Research Institute Faculty
Pharmacological Sciences Graduate Group Faculty
CHOP Provider Profile
Education:
M.D.
Johns Hopkins University School of Medicine, 1970.
Permanent linkM.D.
Johns Hopkins University School of Medicine, 1970.
Description of Research Expertise
Research SummaryHeart Valve Disease: Research programs underway concerning the developmental basis for aortic valve disease, mechanistic studies of progression of calcific aortic stenosis, serotonin mechanisms in heart valve disease, and novel biomaterials for heat valve prostheses.
Gene delivery stents: plasmid or viral vectors configured in sustained release preparations onto vascular stents for site specific vascular gene therapy.
Myocardial gene delivery systems for cardiac arrhythmias: Investigations of controlled release plasmid and viral vector systems for sustained expression of mutant ion channels in re-entrant pathways.
Selected Publications
Chorny M, Alferiev IS, Fishbein I, Tengood JE, Folchman-Wagner Z, Forbes SP, Levy, RJ: Formulation and In Vitro Characterization of Composite Biodegradable Magnetic Nanoparticles for Magnetically Guided Cell Delivery. Pharm Res 29(5): 1232-41, May 2012.Stachelek Stanley J, Finley Matthew J, Alferiev Ivan S, Wang Fengxiang, Tsai Richard K, Eckells Edward C, Tomczyk Nancy, Connolly Jeanne M, Discher Dennis E, Eckmann David M, Levy Robert J: The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials 32(19): 4317-26, Jul 2011.
Balachandran K, Bakay M, Connolly JM, Zhang MS, Yoganathan AP, Levy RJ: Aortic Valve Cyclic Stretch Causes Increased Remodeling Activity and Enhanced Serotonin Receptor Responsiveness. Ann Thorac Surg 92: 147-53, 2011.
Connolly JM, Bakay MA, Alferiev IS, Gorman RC, Gorman JH, Kruth HS, Ashworth PE, Kutty JK, Schoen FJ, Bianco RW, Levy RJ : Triglycidylamine cross-linking combined with ethanol inhibits bioprosthetic heart valve calcification. Ann Thorac Surg 92: 858-865, 2011.
Uttayarat Pimpon, Perets Anat, Li Mengyan, Pimton Pimchanok, Stachelek Stanley J, Alferiev Ivan, Composto Russell J, Levy Robert J, Lelkes Peter I: Micropatterning of three-dimensional electrospun polyurethane vascular grafts. Acta biomaterialia 6(11): 4229-37, Nov 2010.
Ueda Masako, Alferiev Ivan S, Simons Stacey B, Hebbel Robert P, Levy Robert J, Stachelek Stanley J: CD47-dependent molecular mechanisms of blood outgrowth endothelial cell attachment on cholesterol-modified polyurethane. Biomaterials 31(25): 6394-9, Sep 2010.
Stachelek Stanley J, Alferiev Ivan, Ueda Masako, Eckels Edward C, Gleason Kevin T, Levy Robert J: Prevention of polyurethane oxidative degradation with phenolic antioxidants covalently attached to the hard segments: structure-function relationships. Journal of biomedical materials research. Part A 94(3): 751-9, Sep 2010.
Chorny Michael, Hood Elizabeth, Levy Robert J, Muzykantov Vladimir R: Endothelial delivery of antioxidant enzymes loaded into non-polymeric magnetic nanoparticles. Journal of controlled release : official journal of the Controlled Release Society 146(1): 144-51, Aug 2010.
Oyama M A, Levy R J: Insights into serotonin signaling mechanisms associated with canine degenerative mitral valve disease. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 24(1): 27-36, Jan-Feb 2010.
Shawn A. Hunter, H. Scott Rapoport, Jeanne M. Connolly, Ivan Alferiev, James Fulmer, Brandon H. Murti, Mohammadsafa Herfat, Frank R. Noyes, David L. Butler, Robert J. Levy: Biomechanical and biologic effects of meniscus stabilization using triglycidyl amine. Journal of Biomedical Materials Research Part A 93A(1): 235-242, 2010.