Robert J. Levy, MD
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations
Contact information
CHOP
Abramson Pediatric Research Center,
Room 702D
Philadelphia, PA 19104-4318
Abramson Pediatric Research Center,
Room 702D
Philadelphia, PA 19104-4318
Office: 215-590-6119
Fax: 215-590-5454
Fax: 215-590-5454
Email:
levyr@email.chop.edu
levyr@email.chop.edu
Publications
Links
Search PubMed for articles
Joseph Stokes Jr. Research Institute Faculty
CHOP Provider Profile
Pharmacological Sciences Graduate Group Faculty
Search PubMed for articles
Joseph Stokes Jr. Research Institute Faculty
CHOP Provider Profile
Pharmacological Sciences Graduate Group Faculty
Education:
M.D.
Johns Hopkins University School of Medicine, 1970.
Permanent linkM.D.
Johns Hopkins University School of Medicine, 1970.
Description of Research Expertise
Research SummaryHeart Valve Disease: Research programs underway concerning the developmental basis for aortic valve disease, mechanistic studies of progression of calcific aortic stenosis, serotonin mechanisms in heart valve disease, and novel biomaterials for heart valve prostheses.
Gene delivery stents are an area of major interest: plasmid or viral vectors configured in sustained release preparations onto vascular stents for site specific vascular gene therapy.
Magnetic intravascular delivery of nanoparticles to treat arterial disease.
Selected Publications
Fishbein Ilia, Forbes Scott P, Chorny Michael, Connolly Jeanne M, Adamo Richard F, Corrales Ricardo A, Alferiev Ivan S, Levy Robert J: Adenoviral vector tethering to metal surfaces via hydrolyzable cross-linkers for the modulation of vector release and transduction. Biomaterials 34(28): 6938-48, Sep 2013.Ma G, Wang Y, Fishbein I, Yu M, Zhang L, Alferiev IS, Yang J, Song C, Levy RJ: Anchoring of self-assembled plasmid DNA/ anti-DNA antibody/cationic lipid micelles on bisphosphonate-modified stent for cardiovascular gene delivery. Int J Nanomedicine 8: 1029-1035, March 2013.
Chorny Michael, Fishbein Ilia, Tengood Jillian E, Adamo Richard F, Alferiev Ivan S, Levy Robert J: Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors. FASEB J Feb 2013.
Branchetti Emanuela, Sainger Rachana, Poggio Paolo, Grau Juan B, Patterson-Fortin Jeffrey, Bavaria Joseph E, Chorny Michael, Lai Eric, Gorman Robert C, Levy Robert J, Ferrari Giovanni: Antioxidant enzymes reduce DNA damage and early activation of valvular interstitial cells in aortic valve sclerosis. Arteriosclerosis, thrombosis, and vascular biology 33(2): e66-74, Feb 2013.
Finley MJ, Rauova L, Alferiev IS, Weisel JW, Levy RJ, Stachelek SJ. : Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces. Biomaterials 33(24): 5803-5811, Aug 2012.
Chen C-Y , Bertozzi C, Zou Z, Yuan L, Lee J, Lu M-M, Stachelek S, Srinivasan S, Guo L, Vicente A, Mericko P, Levy RJ, Makinen T, Oliver G, Kahn M.: Blood flow reprograms lymphatic vessels to blood vessels through shear-mediated loss of endothelial PROX1. J Clin Invest 122(6): 2006-17, June 2012.
Chorny M, Alferiev IS, Fishbein I, Tengood JE, Folchman-Wagner Z, Forbes SP, Levy, RJ: Formulation and In Vitro Characterization of Composite Biodegradable Magnetic Nanoparticles for Magnetically Guided Cell Delivery. Pharm Res 29(5): 1232-41, May 2012.
Stachelek Stanley J, Finley Matthew J, Alferiev Ivan S, Wang Fengxiang, Tsai Richard K, Eckells Edward C, Tomczyk Nancy, Connolly Jeanne M, Discher Dennis E, Eckmann David M, Levy Robert J: The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials 32(19): 4317-26, Jul 2011.
Balachandran K, Bakay M, Connolly JM, Zhang MS, Yoganathan AP, Levy RJ: Aortic Valve Cyclic Stretch Causes Increased Remodeling Activity and Enhanced Serotonin Receptor Responsiveness. Ann Thorac Surg 92: 147-53, 2011.
Connolly JM, Bakay MA, Alferiev IS, Gorman RC, Gorman JH, Kruth HS, Ashworth PE, Kutty JK, Schoen FJ, Bianco RW, Levy RJ : Triglycidylamine cross-linking combined with ethanol inhibits bioprosthetic heart valve calcification. Ann Thorac Surg 92: 858-865, 2011.