Faculty

Robert J. Levy, MD

faculty photo
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
Abramson Pediatric Research Center - 702D
3615 Civic Center Blvd
Philadelphia, PA 19104-4318
Office: 215-590-6119
Fax: 215-590-5454
Education:
M.D.
Johns Hopkins University School of Medicine, 1970.
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Description of Research Expertise

Research Summary
Heart Valve Disease: Research programs underway concerning the developmental basis for aortic valve disease, mechanistic studies of progression of calcific aortic stenosis, serotonin mechanisms in heart valve disease, and novel biomaterials for heart valve prostheses.

Gene delivery stents are an area of major interest: plasmid or viral vectors configured in sustained release preparations onto vascular stents for site specific vascular gene therapy.

Magnetic delivery of nanoparticles for pharmaceutical and cell therapy to treat arterial disease.

Selected Publications

Castillero E, Fitzpatrick E, Keeney SJ, D’Angelo AM, Pressly BB, Simpson MT, Kurade M, Erwin WC, Moreno V, Camillo C, Shukla HJ, Inamdar VV, Aghali A, Grau JB, Salvati E, Nissim I, Rauova L, Oyama MA, Stachelek SJ, Brown C, Krieger AM, Levy RJ, Ferrari G.: Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation. Science Transl Med. 15(677): eadc9606, Jan 4 2023 Notes: doi: 10.1126/scitranslmed.adc9606.

Abramov A, Xue Y, Zakharchenko A, Kurade MS, Soni R, Levy RJ, Ferrari G..: Bioprosthetic heart valve structural degeneration associated with metabolic syndrome: mitigation with polyoxazoline modification. Proc Natl Acad Sci U S A. 2023 Notes: Accepted for Publication (2022).

Hooshdaran B, Pressly BB, Alferiev IS, Smith JD, Zoltick PW, Tschabrunn CM, Wilensky RL, Gorman RC, Levy RJ, Fishbein I : Stent-Based Delivery of AAV2 Vectors Encoding Oxidation-Resistant apoA1 Sci. Rep. 12(1): 5464, Mar 2022.

Alferiev IS, Fishbein I, Levy RJ, Chorny M : Robust Chemical Strategy for Stably Labeling Polyester-Based Nanoparticles with BODIPY Fluorophores. ACS Appl. Polym. Mater. 4(2): 1196–1206, Feb 2022.

Zakharchenko A, Xue Y, Keeney S, Rock C, Alferiev I, Stachelek S, Takano H, Thomas T, Nagaswami C, Krieger AM, Chorny M, Ferrari G, Levy RJ.: Poly-2-methyl-2-oxazoline modified bioprosthetic heart valve leaflets have enhanced biocompatibility and resist structural degeneration. Proc Natl Acad Sci USA. 119(6): e2120694119, Feb 2022.

Xue Y, Kossar AP, Abramov A, Frasca A, Sun M, Zyablitskaya M, Paik D, Kalfa D, Della Barbera M, Thiene G, Kozaki S, Kawashima T, Gorman JH, Gorman RC, Gillespie MJ, Carreon CK, Sanders SP, Levy RJ, Ferrari G.: Age-related enhanced degeneration of bioprosthetic valves due to leaflet calcification, tissue crosslinking, and structural changes. Cardiovasc Res Page: cvac002, Jan 10 2022 Notes: PMC in process. doi: 10.1093/cvr/cvac002.

Alferiev IS, Hooshdaran B, Pressly BB, Zoltick PW, Stachelek SJ, Chorny M, Levy RJ, Fishbein I.: Intraprocedural endothelial cell seeding of arterial stents via biotin/avidin targeting mitigates in-stent restenosis. Scientific Reports 2022 Notes: accepted for publication November, 2022.

Marro M, Kossar AP, Xue Y, Frasca A, Levy RJ, Ferrari G.: Noncalcific Mechanisms of Bioprosthetic Structural Valve Degeneration. J Am Heart Assoc 10(3): e018921, Feb 2 2021

Rock CA, Keeney S, Zakharchenko A, Takano H, Spiegel DA, Krieger AM, Ferrari G, Levy RJ.: Model studies of advanced glycation end product modification of heterograft biomaterials: The effects of in vitro glucose, glyoxal, and serum albumin on collagen structure and mechanical properties. Acta Biomater S1742-7061(21): 00014-3, Jan 2021 Notes: 10.1016/j.actbio.2020.12.053.

Castillero E, Howsmon DP, Rego BV, Keeney S, Driesbaugh KH, Kawashima T, Xue Y, Camillo C, George I, Gorman RC, Gorman JH 3rd, Sacks MS, Levy RJ, Ferrari G.: Altered Responsiveness to TGFβ and BMP and Increased CD45+ Cell Presence in Mitral Valves Are Unique Features of Ischemic Mitral Regurgitation. Arterioscler Thromb Vasc Biol 41(6): 2049-2062, Jun 2021 Notes: doi: 10.1161/ATVBAHA.121.316111.

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Last updated: 01/05/2023
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