Mortimer Poncz, MD
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations
Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Fax: (267) 426-5476
Email:
poncz@email.chop.edu
poncz@email.chop.edu
Publications
Links
Search PubMed for articles
Cell and Molecular Biology Graduate Group
Joseph Stokes Jr. Research Institute Profile
Pharmacological Sciences Graduate Group
Search PubMed for articles
Cell and Molecular Biology Graduate Group
Joseph Stokes Jr. Research Institute Profile
Pharmacological Sciences Graduate Group
Education:
B.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
Permanent linkB.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
Description of Research Expertise
Research InterestsRole of platelets in thrombus development
Key words: platelet; megakaryocyte; hematopoiesis; thrombosis.
Description of Research
My research efforts focus on the megakaryocyte-platelet-thrombus axis. The process by which hematopoietic stem cells differentiate into megakaryocytes, which then release platelets and the function of platelets in thrombosis and inflammation are the central foci of my laboratory. Many of the studies focus on the biology and pathobiology of the platelet-specific proteins, chemokines Platelet Factor 4 (PF4)/Platelet Basic Protein (PBP) and the integrin alphaIIb/beta3 receptor.
Rotation Projects for 2006-2007
1. Murine models of thrombosis.
2. Regulation of megakaryocyte gene expression.
3. Gene therapy lentiviral studies for bleeding disorders. Chemokine sin thrombosis and angiogenesis.
Lab personnel:
1 grad student
1 MD post-doc
3 PhD post-docs
5 lab techs
1 Assist Prof Res
Selected Publications
Meng R, Wang Y, Yao Y, Zhang Z, Harper DC, Heijnen HF, Sitaram A, Li W, Raposo G, Weiss MJ, Poncz M, Marks MS.: SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. Blood 120: 404-14, 2012.Lambert MP, Reznikov A, Grubbs A, Nguyen Y, Xiao L, Aplenc R, Rauova L, Poncz M. : Platelet factor 4 platelet levels are inversely correlated with steady-state platelet counts and with platelet transfusion needs in pediatric leukemia patients. J Thromb Haemost 10: 1442-6, 2012.
Zaitsev S, Kowalska MA, Neyman M, Carnemolla R, Tliba S, Ding BS, Stonestrom A, Spitzer D, Atkinson JP, Poncz M, Cines DB, Esmon CT, Muzykantov VR. : Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. Blood 119: 4779-85, 2012.
Sachais BS, Litvinov RI, Yarovoi SV, Rauova L, Hinds JL, Rux AH, Arepally GM, Poncz M, Cuker A, Weisel JW, Cines DB. : Dynamic antibody binding properties in the pathogenesis of HIT. Blood 2012.
Wang Yuhuan, Meng Ronghua, Hayes Vincent, Fuentes Rudy, Yu Xiang, Abrams Charles S, Heijnen Harry F G, Blobel Gerd A, Marks Michael S, Poncz Mortimer: Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction. Blood 118(23): 6183-91, Dec 2011.
Ahmad F, Boulaftali Y, Greene T K, Ouellette T D, Poncz M, Feske S, Bergmeier W: Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis. Journal of thrombosis and haemostasis : JTH 9(10): 2077-86, Oct 2011.
Kowalska M Anna, Krishnaswamy Sriram, Rauova Lubica, Zhai Li, Hayes Vincent, Amirikian Karine, Esko Jeffrey D, Bougie Daniel W, Aster Richard H, Cines Douglas B, Poncz Mortimer: Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT. Blood 118(10): 2882-8, Sep 2011.
Lambert Michele P, Xiao Liqing, Nguyen Yvonne, Kowalska M Anna, Poncz Mortimer: The role of platelet factor 4 in radiation-induced thrombocytopenia. International journal of radiation oncology, biology, physics 80(5): 1533-40, Aug 2011.
DiCarlo Andrea L, Poncz Mortimer, Cassatt David R, Shah Jui R, Czarniecki Christine W, Maidment Bert W: Medical countermeasures for platelet regeneration after radiation exposure. Report of a workshop and guided discussion sponsored by the National Institute of Allergy and Infectious Diseases, Bethesda, MD, March 22–23, 2010. Radiation research 176(1): e0001-15, Jul 2011.
DiCarlo Andrea L, Poncz Mortimer, Cassatt David R, Shah Jui R, Czarniecki Christine W, Maidment Bert W: Development and licensure of medical countermeasures for platelet regeneration after radiation exposure. Radiation research 176(1): 134-7, Jul 2011.