Perelman School of Medicine at the University of Pennsylvania

Penn Institute for Immunology

Bruce J Shenker

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Contact information

Georgetown University, 4.
Syracuse University, 4.
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Selected Publications

Maserejian Nancy N, Shrader Peter, Brown Olivia A, Trachtenberg Felicia L, Soncini Jennifer, Hauser Russ, Shenker Bruce J: Dental sealants and composite restorations and longitudinal changes in immune function markers in children. International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children 24(3): 215-25, May 2014.

Shenker Bruce J, Walker Lisa P, Zekavat Ali, Dlakić Mensur, Boesze-Battaglia Kathleen: Blockade of the PI-3K signalling pathway by the Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces macrophages to synthesize and secrete pro-inflammatory cytokines. Cellular microbiology Apr 2014.

Shenker Bruce J, Ali Hydar, Boesze-Battaglia Kathleen: PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases. Current pharmaceutical design 17(34): 3815-22, Nov 2011.

Krummenacher, C., Brown, A., Shenker, B.J., Edrington, V., and Boesze-Battaglia, K.: Mechanisms by which pathogens hijack and utilize membrane domains to mediate cytotoxicity. The structure of biological membrane, 3rd edition. 2011.

Shenker Bruce J, Boesze-Battaglia Kathleen, Zekavat Ali, Walker Lisa, Besack Dave, Ali Hydar: Inhibition of mast cell degranulation by a chimeric toxin containing a novel phosphatidylinositol-3,4,5-triphosphate phosphatase. Molecular immunology 48(1-3): 203-10, Nov-Dec 2010.

Boesze-Battaglia Kathleen, Brown Angela, Walker Lisa, Besack Dave, Zekavat Ali, Wrenn Steve, Krummenacher Claude, Shenker Bruce J: Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. The Journal of biological chemistry 284(16): 10650-8, Apr 2009.

Shenker Bruce J, Maserejian Nancy N, Zhang Annie, McKinlay Sonja: Immune function effects of dental amalgam in children: a randomized clinical trial. Journal of the American Dental Association (1939) 139(11): 1496-505, Nov 2008.

Shenker Bruce J, Dlakic Mensur, Walker Lisa P, Besack Dave, Jaffe Eileen, LaBelle Ed, Boesze-Battaglia Kathleen: A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity. Journal of immunology (Baltimore, Md. : 1950) 178(8): 5099-108, Apr 2007.

Boesze-Battaglia Kathleen, Besack Dave, McKay Terry, Zekavat Ali, Otis Linda, Jordan-Sciutto Kelly, Shenker Bruce J: Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin. Cellular microbiology 8(5): 823-36, May 2006.

Shenker Bruce J, Demuth Donald R, Zekavat Ali: Exposure of lymphocytes to high doses of Actinobacillus actinomycetemcomitans cytolethal distending toxin induces rapid onset of apoptosis-mediated DNA fragmentation. Infection and immunity 74(4): 2080-92, Apr 2006.

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Last updated: 04/26/2013
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