Laura McLane and Mike Betts -Purified human CD8 T-cells were stained with a-T-bet (green), a-Lamin A (pink), and DAPI (blue) and imaged on a multilaser-based spinning disk confocal microscope (Zeiss). T-bet can be localized to both the nuclear and cytoplasmic compartments of specific subsets of human CD8 T-cells.
3D image of the inflamed meningeal membrane of a CX3CR1-GFP reporter mouse infected with Toxoplasma gondii. The dura mater that surrounds the brain is blue, blood vessels are labeled red and microglia and macrophages are green. Contributors for image are ChristophKonradt and Chris Hunter.
Time series of cells expressing GFP-tagged ebola viral protein VP40, pseudocolored as a fluorescence intensity heatmap. The contributors for image are: Gordon Ruthel, Xiaohong Liu, Ron Harty, and Bruce Freedman.
*Advance our knowledge of the basic immunology of inflammation, autoimmunity, cancer, transplantation and infection and to translate this new knowledge to novel strategies for diagnosis, prevention and therapeutic intervention.
*Foster collaborations and further strengthen interactions among the Penn community of immunologists.
Spotlights on IFI
HIV Helped Utah Man Battle Cancer: How Disabled HIV Turns T-Cells Into "Serial Killers" of Turmos
Dr. Carl June and his team found a way of using the HIV
virus to turn a patient's immune system T-cells into leukemia-specific
Click this link to read more about this amazing story.
James L. Riley, PhD, Recipient of the Lady Barbara Colyton Prize for Autoimmune Research Award
Immunology in the News