Critical Care Medicine
Acute respiratory distress syndrome
Dr. Meyer’s research focuses on identifying genetic and molecular risk factors for acute respiratory distress syndrome and organ dysfunction during critical illness. She seeks to leverage genetic risk profiles to allow the development of personalized therapy for sepsis and ARDS. By directing a cohort of patients with severe sepsis, Dr. Meyer’s research spans the clinical, genetic, and molecular fields, translating human associations with lung injury into mechanistic insights as to how acute lung injury occurs, and transforming this enhanced understanding into improved care for patients.
Nuala J Meyer, Rui Feng, Mingyao Li, Yang Zhou, Chau-Chun Sheu, Paula Tejera, Robert Gallop, Scarlett Bellamy, Melanie Rushefski, Paul N. Lanken, Richard Aplenc, Grant E. O'Keefe, Mark M Wurfel, David C Christiani, and Jason D. Christie
: IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL1RA. American Journal of Respiratory and Critical Care Medicine 187(9): 950-9, May 2013.
Meyer Nuala J, Li Mingyao, Feng Rui, Bradfield Jonathan, Gallop Robert, Bellamy Scarlett, Fuchs Barry D, Lanken Paul N, Albelda Steven M, Rushefski Melanie, Aplenc Richard, Abramova Helen, Atochina-Vasserman Elena N, Beers Michael F, Calfee Carolyn S, Cohen Mitchell J, Pittet Jean-Francois, Christiani David C, O'Keefe Grant E, Ware Lorraine B, May Addison K, Wurfel Mark M, Hakonarson Hakon, Christie Jason D: ANGPT2 Genetic Variant Is Associated with Trauma-associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio. American Journal of Respiratory and Critical Care Medicine 183(10): 1344-53, May 2011.
Meyer Nuala J, Daye Z John, Rushefski Melanie, Aplenc Richard, Lanken Paul N, Shashaty Michael G S, Christie Jason D, Feng Rui: SNP-set analysis replicates acute lung injury genetic risk factors. BMC Medical Genetics 13(1): 52, Jun 2012.
Christie Jason D, Wurfel Mark M, Feng Rui, O'Keefe Grant E, Bradfield Jonathan, Ware Lorraine B, Christiani David C, Calfee Carolyn S, Cohen Mitchell J, Matthay Michael, Meyer Nuala J, Kim Cecilia, Li Mingyao, Akey Joshua, Barnes Kathleen C, Sevransky Jonathan, Lanken Paul N, May Addison K, Aplenc Richard, Maloney James P, Hakonarson Hakon: Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PloS one 7(1): e28268, Jan 2012.
Dolinay Tamás, Kim Young Sam, Howrylak Judie, Hunninghake Gary M, An Chang Hyeok, Fredenburgh Laura, Massaro Anthony F, Rogers Angela, Gazourian Lee, Nakahira Kiichi, Haspel Jeffrey A, Landazury Roberto, Eppanapally Sabitha, Christie Jason D, Meyer Nuala J, Ware Lorraine B, Christiani David C, Ryter Stefan W, Baron Rebecca M, Choi Augustine M K: Inflammasome-Regulated Cytokines are Critical Mediators of Acute Lung Injury. American Journal of Respiratory and Critical Care Medicine 185(11): 1225-1234, Jun 2012.
Meyer, Nuala J. : Future Clinical Applications of Genomics to Acute Respiratory Distress Syndrome. Lancet Resp Med 1(10): 793-803, Dec 2013 Notes: Early Online Publication, 19 August 2013.
Meyer, Nuala J and Christie, Jason D: Genetic Heterogeneity and Risk of ARDS. Seminars in Respiratory and Critical Care Medicine 34(4): 459-74, August 2013.
Rushefski Melanie, Aplenc Richard, Meyer Nuala, Li Mingyao, Feng Rui, Lanken Paul N, Gallop Robert, Bellamy Scarlett, Localio A Russell, Feinstein Sheldon I, Fisher Aron B, Albelda Steven M, Christie Jason D: Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma. BMC Medical Genetics 12: 77, May 2011.
Meyer NJ, Christie JD: The next generation of ALI genetics: insights into pathophysiology. In: Annual Update in Intensive Care and Emergency Medicine 2011. JL Vincent (eds.). Springer, Page: 97-108, March 2011.
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Last updated: 02/18/2016
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