Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Faculty

Lachlan James Smith

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Assistant Professor of Neurosurgery
Department: Neurosurgery

Contact information
McKay Orthopaedic Research Laboratory
111A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 215-898-8653
Fax: 215-573-2133
Education:
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
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Description of Research Expertise

The focus of my research program is the pathophysiology and treatment of degenerative and developmental disorders affecting the spine, particularly those affecting the intervertebral discs and vertebral bones. The scope of our research includes basic mechanistic studies, translational studies in animal models, and clinical studies in human patients. We use cutting edge techniques in molecular biology, biochemistry and bioengineering, coupled with novel in vitro model systems to study disease mechanisms. Our research in the translational space bridges the fields of tissue engineering, biomaterials, drug delivery and stem cells, and is focused on arresting disease progression, restoring spine function and potentiating long term tissue regeneration. We use novel, naturally occurring and inducible large and small animal models to study disease etiology and evaluate therapeutics. Our multidisciplinary team includes biologists, bioengineers, clinicians and veterinarians.

Selected Publications

Gullbrand SE, Kim DH, Bonnevie E, Ashinsky BG, Smith LJ, Elliott DM, Mauck RL, Smith HE: Development of Tissue Engineered Intervertebral Discs at Clinically Relevant Size Scales. Acta Biomaterialia 70: 154-164, Apr 2018.

Nayak NR, Piazza M, Milby A, Thawani JP, Smith LJ, Stein SC, Malhotra NR: Surgical Approaches for the Treatment of Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: Results of a Decision Analysis. World Neurosurgery 112: e375-e384, Apr 2018.

Tian Z, Yasen M, Ma X, Mauck RL, Qin L, Shofer FS, Smith LJ, Pacifici M, Enomoto-Iwamoto M, Zhang Y: Intervertebral Disc Degeneration in a Percutaneous Mouse Tail Injury Model. American Journal of Physical Medicine & Rehabilitation 97(3): 170-177, Mar 2018.

Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Zhang Y, Smith HE, Malhotra NR, Smith LJ: Quantitative magnetic resonance imaging correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration Journal of Orthopaedic Research In press, 2018.

Piazza M, Sharma N, Osiemo B, McClintock S, Missimer E, Gardiner D, Maloney EM, Callahan D, Smith, LJ, Welch WC, Schuster JM, Grady MS, Malhotra NR: Initial Assessment of the Risk Assessment and Prediction Tool in a Heterogeneous Neurosurgical Population. Neurosurgery In press, 2018.

Gullbrand SE, Ashinsky BG, Kim DH, Smith LJ, Elliott DM, Smith HE, Mauck RL: The Effect of Remobilization on the In Vivo Function of an Endplate-Modified Engineered Disc. 64th Annual Meeting, Orthopaedic Research Society, New Orleans, USA 2018 Notes: Poster presentation.

Peck SH, Bendigo JR, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Donor-Dependent Effects on the Survival and Extracellular Matrix Producing Capacity of Mesenchymal Stem Cells following Hypoxia and TGF-β Conditioning. 64th Annual Meeting, Orthopaedic Research Society, New Orleans, USA 2018 Notes: Poster presentation.

Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Arginteanu T, Smith HE, Malhotra NR, Smith LJ: Quantitative magnetic resonance imaging correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration. 64th Annual Meeting, Orthopaedic Research Society, New Orleans, USA 2018 Notes: Poster presentation.

Kim DH, Gullbrand SE, Elliott DM, Smith LJ, Smith HE, Mauck RL: TGF-β Improves Cell Viability in Human-Sized Disc-Like Angle Ply Structures (DAPS). 64th Annual Meeting, Orthopaedic Research Society, New Orleans, USA 2018 Notes: Poster presentation.

Riester SM, Lin Y, Wang W, Cong L, Ali AM, Peck SH, Smith LJ, Currier B, Clark M, Huddleston P, Krauss W, Yaszemski MJ, Morrey ME, Abdel MP, Bydon M, Qu W, Larson AN, Wijnen AJ, Nassr A: RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues. Journal of Orthopaedic Research In press, Dec 2017 Notes: DOI: 10.1002/jor.23834.

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Last updated: 04/25/2018
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