Lachlan James Smith

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Associate Professor of Neurosurgery
Department: Neurosurgery

Contact information
McKay Orthopaedic Research Laboratory
378A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-2169
Fax: 215-573-2133
Education:
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
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Description of Research Expertise

The focus of my research program is the pathophysiology and treatment of degenerative and developmental disorders affecting the spine, particularly those affecting the intervertebral discs and vertebral bones. The scope of our research includes basic mechanistic studies, translational studies in animal models, and clinical studies in human patients. We use cutting edge techniques in molecular biology, biochemistry and bioengineering, coupled with novel in vitro model systems to study disease mechanisms. Our research in the translational space bridges the fields of tissue engineering, biomaterials, drug delivery and stem cells, and is focused on arresting disease progression, restoring spine function and potentiating long term tissue regeneration. We use novel, naturally occurring and inducible large and small animal models to study disease etiology and evaluate therapeutics. Our multidisciplinary team includes biologists, bioengineers, clinicians and veterinarians.

Selected Publications

Zhang C, Schaer TP, Gullbrand SE, Jiang Z, Lau YK, Elliott DM, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Inflammatory Cytokine and Catabolic Enzyme Expression in a Goat Model of Intervertebral Disc Degeneration. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020.

Zhang C, Gullbrand SE, Schaer TP, Elliott DM, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Combined Hydrogel and Mesenchymal Stem Cell Therapy Improves Disc Height and Condition in a Goat Model of Disc Degeneration. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020.

Jiang Z, Lau YK, Casal ML, Smith LJ: Ultrastructural Analysis of Different Skeletal Cell Types in Mucopolysaccharidosis Dogs at the Onset of Postnatal Growth. 66th Annual Meeting. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020.

Jiang Z, Johnson CP, Nykänen O, Nissi M, Lau YK, Wu M, Ludwig K, Ellerman J, Casal ML, Smith LJ: Abnormal Vascularity and Extracellular Matrix Remodeling are Associated with Delayed Secondary Ossification in Mucopolysaccharidosis VII. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020.

Gullbrand SE, Ashinsky BG, Bonnevie ED, Kim DH, Smith LJ, Elliott DM, Schaer TP, Smith HE, Mauck RL: Engineered Total Disc Replacements in a Large Animal Model Recapitulate Native Disc Structure and Function. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020.

Pasha S, Smith LJ, Sankar WN: Bone Remodeling and Disc Morphology in the Distal Unfused Spine after Spinal Fusion in Adolescent Idiopathic Scoliosis. Spinal Deformity 7(5): 746-753, Sep 2019.

Peck SH, Tobias JW, Shore EM, Malhotra NR, Haskins ME, Casal ML, Smith LJ: Molecular Profiling of Failed Endochondral Ossification in Mucopolysaccharidosis VII. Bone 128, Aug 2019.

Peck SH, Bendigo JR, Tobias JW, Dodge GR, Malhotra NR, Mauck RL, Smith LJ: Hypoxic preconditioning enhances bone marrow-derived mesenchymal stem cell survival in a low oxygen and nutrient-limited 3D microenvironment. Cartilage In press, Apr 2019.

Tanpaiboon P, Smith LJ, Casal ML, Chang Y-C, Nampoothiri S, Paiyarom A, Kuptanon C, Trachoo O, Ketudat Cairns JR, Kantaputra PN: Oral Manifestations of Patients and Dogs with Mucopolysaccharidosis Type VII. American Journal of Medical Genetics Part A 179(3): 486-493, Mar 2019.

Zhang C, Gullbrand SE, Schaer TP, Elliott DM, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Inflammatory Cytokine Expression in a Goat Model of Intervertebral Disc Degeneration. 65th Annual Meeting, Orthopaedic Research Society, Austin, USA 2019.

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Last updated: 09/13/2019
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