Welcome to McKay Orthopaedic Research Laboratory

A program in orthopaedic research at the University of Pennsylvania was established in 1960, and in 1979 the McKay Orthopaedic Research Laboratory officially opened, establishing all of the orthopaedic research laboratories in the same physical location. Currently, the McKay Lab is a thriving, multidisciplinary facility that occupies more than 22,000 square feet of space in Stemmler Hall in the Perelman School of Medicine. Our multi-faceted research programs involve the participation of more than 120 research personnel from 17 distinct laboratories. Research expenditures in McKay total more than $15,000,000 per annum, supported largely through extramural funding including grants from the National Institutes of Health, Veteran's Administration, other governmental agencies, private foundations, and industry. We are consistently ranked in the top 5 among Orthopaedic Departments nationally in terms of NIH funding. Our overall mission is to conduct high quality fundamental and translational research and to train the next generation of leaders in our field. Moreover, the McKay Lab serves as the focal point for the NIH-supported Penn Center for Musculoskeletal Disorders, a university-wide Center that provides resources and a forum for scientific exchange through annual symposia, a year-long seminar series, a pilot grant program and other activities. 

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McKay Laboratory News

Congratulations to Dr. Sarah Gullbrand and Coauthors on European Cells and Materials Publication
April 23, 2024
Congratulations to Dr. Gullbrand and coauthors on their publication in European Cells and Materials. The study, entitled "Intervertebral Disc Degeneration Instigates Vertebral Endplate Remodeling and Facet Joint Pathology in a Large Animal Model," characterizes the degenerative changes that occur across all substructures of the spine following induction of intervertebral disc degeneration in an initially healthy spine using chondroitinase ABC.
Mauck LaboratoryGullbrand Laboratory

Congratulations to Cait Barrett on winning Best Podium at Drexel's Orthopaedic Research Day
April 21, 2024
Congratulations to Caitlin Barrett on winning Best Podium at Drexel's Orthopaedic Research Day for her podium entitled "Innervation and Inflammation Correlate with Structural and Mechanical Changes in a Large Animal Model of Intervertebral Disc Degeneration"
Gullbrand Laboratory

Congratulations to Loreilys Mejias Rivera
April 05, 2024
Congratulations to Loreilys and coauthors on their publication in mdpi Biomedicines. The review, entitled "Cellular and Molecular Mechanisms of Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva" discuss the emerging role of ACVR1R206H FAPs in muscle regeneration and therapeutic targeting of these cells to reduce formation of heterotopic ossification in FOP.
Mourkioti LaboratoryShore Laboratory

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Congratulations to the new Penn Medicine Achilles Tendon Research Center and the Center founding Director Dr. Lou Soslowsky.  See article at Penn Medicine News

February 7, 2023 - Penn Almanac Press Release

Congratulations to the McKay Orthopaedic Research Laboratory for being Ranked #1 in 2021 for NIH Funding. See article at Penn Medicine News

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